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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sle3NZM2410/Aeg
NZM2410/Aeg
MGI:2156753
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Sle1NZM2410/Aeg/Sle1NZM2410/Aeg
Sle3NZM2410/Aeg/Sle3NZM2410/Aeg 		B6;NZM-Sle1NZM2410/Aeg Sle2NZM2410/Aeg Sle3NZM2410/Aeg/LmoJ MGI:3839653
ot2
 		Sle3NZM2410/Aeg/? involves: C57BL/6J * NZM2410/Aeg MGI:2175590


Genotype
MGI:3839653
cx1
Allelic
Composition		 Sle1NZM2410/Aeg/Sle1NZM2410/Aeg
Sle3NZM2410/Aeg/Sle3NZM2410/Aeg
Genetic
Background		 B6;NZM-Sle1NZM2410/Aeg Sle2NZM2410/Aeg Sle3NZM2410/Aeg/LmoJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sle1NZM2410/Aeg mutation (2 available); any Sle1 mutation (2 available)
Sle2NZM2410/Aeg mutation (1 available); any Sle2 mutation (1 available)
Sle3NZM2410/Aeg mutation (1 available); any Sle3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased marginal zone B cell number ( J:138314 )
• increased proportion of B220+ CD1dhi splenic B cells
abnormal marginal zone B cell physiology ( J:138314 )
• impaired TI-2 antigen binding capacity
• increased intrafollicular localization of IgM+ CD1dhi B cells

immune system
increased marginal zone B cell number ( J:138314 )
• increased proportion of B220+ CD1dhi splenic B cells
abnormal marginal zone B cell physiology ( J:138314 )
• impaired TI-2 antigen binding capacity
• increased intrafollicular localization of IgM+ CD1dhi B cells




Genotype
MGI:2175590
ot2
Allelic
Composition		 Sle3NZM2410/Aeg/?
Genetic
Background		 involves: C57BL/6J * NZM2410/Aeg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sle3NZM2410/Aeg mutation (1 available); any Sle3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
glomerulonephritis ( J:52863 )
• severe glomerulonephritis

renal/urinary system
glomerulonephritis ( J:52863 )
• severe glomerulonephritis

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory