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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp110tm1Mpin
targeted mutation 1, Max-Planck-Institute for Neurobiology
MGI:2156881
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp110tm1Mpin/Zfp110tm1Mpin 129S2.Cg-Zfp110tm1Mpin MGI:3039700
hm2
 		Zfp110tm1Mpin/Zfp110tm1Mpin B6.Cg-Zfp110tm1Mpin MGI:3039701
hm3
 		Zfp110tm1Mpin/Zfp110tm1Mpin involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl MGI:3039702


Genotype
MGI:3039700
hm1
Allelic
Composition		 Zfp110tm1Mpin/Zfp110tm1Mpin
Genetic
Background		 129S2.Cg-Zfp110tm1Mpin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp110tm1Mpin mutation (1 available); any Zfp110 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:66924 )
• Background Sensitivity: unlike animals on a congenic B6 background, these animals were viable and healthy to adulthood




Genotype
MGI:3039701
hm2
Allelic
Composition		 Zfp110tm1Mpin/Zfp110tm1Mpin
Genetic
Background		 B6.Cg-Zfp110tm1Mpin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp110tm1Mpin mutation (1 available); any Zfp110 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
decreased embryo size ( J:66924 )
• severe growth retardation evident at E12

growth/size/body
decreased embryo size ( J:66924 )
• severe growth retardation evident at E12




Genotype
MGI:3039702
hm3
Allelic
Composition		 Zfp110tm1Mpin/Zfp110tm1Mpin
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp110tm1Mpin mutation (1 available); any Zfp110 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:66924 )
• incomplete penetrance, 20% of progeny die before or shortly after birth

endocrine/exocrine glands
decreased testis weight ( J:66924 )
• up to 70% reduction in testis weight, age-dependent
• males fertile and no other obvious morphological alterations in testis

reproductive system
decreased testis weight ( J:66924 )
• up to 70% reduction in testis weight, age-dependent
• males fertile and no other obvious morphological alterations in testis

vision/eye
decreased retina apoptosis ( J:66924 )
• reduced levels of cell death in developing retina compared to littermate controls

cellular
decreased retina apoptosis ( J:66924 )
• reduced levels of cell death in developing retina compared to littermate controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory