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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt1tm2Jae
targeted mutation 2, Rudolf Jaenisch
MGI:2156895
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dnmt1tm2Jae/Dnmt1tm2Jae
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:3687459
cn2
 		Bcl11atm1Pwt/Bcl11atm1Pwt
Dnmt1tm2Jae/Dnmt1+
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:5515307


Genotype
MGI:3687459
cn1
Allelic
Composition		 Dnmt1tm2Jae/Dnmt1tm2Jae
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dnmt1tm2Jae mutation (1 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:113645 )
• there is complete block of B cell development in spleen and bone marrow
decreased pro-B cell number ( J:113645 )
• proportion of CD19+ lymphocytes is 10% compared to 74% in wild-type

hematopoietic system
abnormal B cell differentiation ( J:113645 )
• there is complete block of B cell development in spleen and bone marrow
decreased pro-B cell number ( J:113645 )
• proportion of CD19+ lymphocytes is 10% compared to 74% in wild-type




Genotype
MGI:5515307
cn2
Allelic
Composition		 Bcl11atm1Pwt/Bcl11atm1Pwt
Dnmt1tm2Jae/Dnmt1+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation (0 available); any Bcl11a mutation (44 available)
Dnmt1tm2Jae mutation (1 available); any Dnmt1 mutation (112 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
anemia ( J:196140 )
• mild




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory