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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Csf3rtm1Link
targeted mutation 1, Daniel C Link
MGI:2156982
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Csf3rtm1Link/Csf3rtm1Link B6.129X1-Csf3rtm1Link MGI:3836738
hm2
 		Csf3rtm1Link/Csf3rtm1Link involves: 129X1/SvJ MGI:3836735
hm3
 		Csf3rtm1Link/Csf3rtm1Link involves: 129X1/SvJ * NIH Black Swiss MGI:2183035
cn4
 		Adam10tm1.1Khr/Adam10tm1.1Khr
Csf3rtm1Link/Csf3rtm1Link
Tg(Mx1-cre)1Cgn/0 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6N MGI:5305469


Genotype
MGI:3836738
hm1
Allelic
Composition		 Csf3rtm1Link/Csf3rtm1Link
Genetic
Background		 B6.129X1-Csf3rtm1Link
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm1Link mutation (1 available); any Csf3r mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:79567 )
• no mobilization in response to granulocyte-colony stimulating factor (G-CSF)

cellular
impaired neutrophil chemotaxis ( J:79567 )
• no mobilization in response to granulocyte-colony stimulating factor (G-CSF)

hematopoietic system
impaired neutrophil chemotaxis ( J:79567 )
• no mobilization in response to granulocyte-colony stimulating factor (G-CSF)




Genotype
MGI:3836735
hm2
Allelic
Composition		 Csf3rtm1Link/Csf3rtm1Link
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm1Link mutation (1 available); any Csf3r mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:79825 )
• chemotaxis response to Il8 is significantly reduced

cellular
impaired neutrophil chemotaxis ( J:79825 )
• chemotaxis response to Il8 is significantly reduced

hematopoietic system
impaired neutrophil chemotaxis ( J:79825 )
• chemotaxis response to Il8 is significantly reduced




Genotype
MGI:2183035
hm3
Allelic
Composition		 Csf3rtm1Link/Csf3rtm1Link
Genetic
Background		 involves: 129X1/SvJ * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm1Link mutation (1 available); any Csf3r mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell morphology/development ( J:37618 )
• decreased numbers of mature myeloid cells in bone marrow but normal megakaryocyte levels and overall cellularity is normal
decreased bone marrow cell number ( J:37618 )
• metamyelocytes and granulocyte numbers are reduced 50%
decreased neutrophil cell number ( J:37618 )
• 12% normal levels of circulating neutrophils while other blood cell counts are normal
decreased hematopoietic stem cell number ( J:37618 )
• total numbers of hematopoietic progenitor cells in bone marrow is reduced
abnormal monocyte morphology ( J:37618 )
• higher levels of apoptosis in cultured bone marrow mononuclear cells
decreased monocyte cell number ( J:37618 )
• monocyte numbers in peripheral blood are reduced about 50%

immune system
decreased neutrophil cell number ( J:37618 )
• 12% normal levels of circulating neutrophils while other blood cell counts are normal
abnormal monocyte morphology ( J:37618 )
• higher levels of apoptosis in cultured bone marrow mononuclear cells
decreased monocyte cell number ( J:37618 )
• monocyte numbers in peripheral blood are reduced about 50%




Genotype
MGI:5305469
cn4
Allelic
Composition		 Adam10tm1.1Khr/Adam10tm1.1Khr
Csf3rtm1Link/Csf3rtm1Link
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1.1Khr mutation (0 available); any Adam10 mutation (38 available)
Csf3rtm1Link mutation (1 available); any Csf3r mutation (42 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal granulocyte differentiation ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
enlarged spleen ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
myeloid hyperplasia ( J:179060 )
• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with Csf3rtm1Link homozygotes

cellular
abnormal granulocyte differentiation ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r

immune system
abnormal granulocyte differentiation ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
enlarged spleen ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
myeloid hyperplasia ( J:179060 )
• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with Csf3rtm1Link homozygotes

growth/size/body
enlarged spleen ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
spleen hyperplasia ( J:179060 )
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory