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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Coq7tm1Hek
targeted mutation 1, Siegfried Hekimi
MGI:2157003
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Coq7tm1Hek/Coq7tm1Hek involves: 129S1/Sv * 129X1/SvJ MGI:2665329
ht2
 		Coq7tm1Hek/Coq7+ B6.129-Coq7tm1Hek MGI:3826394
ht3
 		Coq7tm1Hek/Coq7+ involves: 129S1/Sv * 129X1/SvJ MGI:2665330
ht4
 		Coq7tm1Hek/Coq7+ involves: 129S1/Sv * 129X1/SvJ * BALB/c MGI:3826393
cn5
 		Coq7tm1Hek/Coq7tm2Hek
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5532534


Genotype
MGI:2665329
hm1
Allelic
Composition		 Coq7tm1Hek/Coq7tm1Hek
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7tm1Hek mutation (0 available); any Coq7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Severe developmental delay in Coq7tm1Hek/Coq7tm1Hek embryos

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:73121 )
• homozygous embryos failed to survive beyond E12.5

embryo
embryonic growth retardation ( J:73121 )
• homozygous embryos showed a developmental delay by E9.5
decreased embryo size ( J:73121 )
• homozygous embryos showed a developmental delay by E9.5

growth/size/body
embryonic growth retardation ( J:73121 )
• homozygous embryos showed a developmental delay by E9.5
decreased embryo size ( J:73121 )
• homozygous embryos showed a developmental delay by E9.5




Genotype
MGI:3826394
ht2
Allelic
Composition		 Coq7tm1Hek/Coq7+
Genetic
Background		 B6.129-Coq7tm1Hek
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7tm1Hek mutation (0 available); any Coq7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:102109 )
• heterozygous mice lived significantly longer than their wild-type littermates




Genotype
MGI:2665330
ht3
Allelic
Composition		 Coq7tm1Hek/Coq7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7tm1Hek mutation (0 available); any Coq7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:102109 )
• female heterozygous mice lived on average 15% longer than their wild-type littermates




Genotype
MGI:3826393
ht4
Allelic
Composition		 Coq7tm1Hek/Coq7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7tm1Hek mutation (0 available); any Coq7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:102109 )
• heterozygous mice lived on average 31% longer than their wild-type littermates

cellular
abnormal mitochondrial physiology ( J:278535 )
• mice exhibit a reduced ubiquinone levels in the inner membrane but increased levels in the outer membrane compared with wild-type mice
• however, dietary coenzyme Q10 supplementation reversed the phenotype




Genotype
MGI:5532534
cn5
Allelic
Composition		 Coq7tm1Hek/Coq7tm2Hek
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7tm1Hek mutation (0 available); any Coq7 mutation (29 available)
Coq7tm2Hek mutation (0 available); any Coq7 mutation (29 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:202240 )
N
• mice exhibit normal mortality

liver/biliary system
liver/biliary system phenotype ( J:202240 )
N
• mice exhibit normal liver morphology
abnormal liver physiology ( J:202240 )
• mild reduction in respiratory capacity in liver mitochondria
• however, a diet supplemented with dietary ubiquinine rescues respiratory chain function

cellular
abnormal respiratory electron transport chain ( J:202240 )
• mild reduction in respiratory capacity in liver mitochondria
• however, a diet supplemented with dietary ubiquinine rescues respiratory chain function




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory