Phenotypes associated with this allele

• Allele Symbol: Pttg1^tm1Sme
• Allele Name: targeted mutation 1, Shlomo Melmed
• Allele ID: MGI:2157014
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pttg1^tm1Sme/Pttg1^tm1Sme	involves: 129S4/SvJae * C57BL/6	MGI:3056896

Genotype
MGI:3056896

hm1

• Allelic Composition: Pttg1^tm1Sme/Pttg1^tm1Sme
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal epididymal fat pad morphology ( J:82724 )

• loss of epididymal fat pad mass in males after 6 months

cellular

decreased pancreatic beta cell proliferation ( J:82724 )

• impaired beta cell proliferation in adult males

behavior/neurological

increased food intake ( J:82724 )

• increased food uptake in adult males

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:82724 )

• impaired beta cell proliferation in adult males

abnormal pancreatic beta cell morphology ( J:82724 )

• 3% of beta cells in 3 month old males are large with macronuclei, multiple nuclei and absent intranuclear septa

decreased pancreatic beta cell mass ( J:82724 )

• reduced islet beta cell mass in adult males

thymus hyperplasia ( J:72267 )

• thymus enlarged to 115-135% of wild-type

• enlargement most pronounced between 4-5 weeks

decreased testis weight ( J:72267 )

♂ • adult testicle weight reduced to 45-55% of wildtype

growth/size/body

decreased body weight ( J:82724 )

• at 6 months males show no further weight gain

hematopoietic system

thymus hyperplasia ( J:72267 )

• thymus enlarged to 115-135% of wild-type

• enlargement most pronounced between 4-5 weeks

thrombocytopenia ( J:72267 )

• platelets reduced to 40-65% of wildtype

increased T cell number ( J:72267 )

• increased CD4+CD8- cells in thymus

decreased spleen weight ( J:72267 )

• reduced spleen weight (50-75%) observed at weaning

decreased immunoglobulin level ( J:72267 )

• impaired IgM and IgG1a antibody production in response to keyhole limpet hemocyanin

decreased IgG level ( J:72267 )

decreased IgM level ( J:72267 )

homeostasis/metabolism

hyperglycemia ( J:82724 )

• fasting hyperglycemia develops in males after 6 months

• fasting hyperglycemia develops in females only after ovary removal

decreased circulating insulin level ( J:82724 )

• decreased insulin production in males over 6 months

increased bleeding time ( J:72267 )

immune system

increased T cell number ( J:72267 )

• increased CD4+CD8- cells in thymus

decreased immunoglobulin level ( J:72267 )

• impaired IgM and IgG1a antibody production in response to keyhole limpet hemocyanin

decreased IgG level ( J:72267 )

decreased IgM level ( J:72267 )

abnormal immune system organ morphology ( J:72267 )

thymus hyperplasia ( J:72267 )

• thymus enlarged to 115-135% of wild-type

• enlargement most pronounced between 4-5 weeks

decreased spleen weight ( J:72267 )

• reduced spleen weight (50-75%) observed at weaning

renal/urinary system

polyuria ( J:82724 )

• observed in males after 6 months

reproductive system

decreased testis weight ( J:72267 )

♂ • adult testicle weight reduced to 45-55% of wildtype

reduced female fertility ( J:72267 )

♀

decreased litter size ( J:72267 )

• average litter size smaller than wildtype