Phenotypes associated with this allele

• Allele Symbol: Rasgrf1^tm1Kln
• Allele Name: targeted mutation 1, Rudiger Klein
• Allele ID: MGI:2157015
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasgrf1^tm1Kln/Rasgrf1^tm1Kln	involves: 129/Sv * C57BL/6	MGI:3851194

Genotype
MGI:3851194

hm1

• Allelic Composition: Rasgrf1^tm1Kln/Rasgrf1^tm1Kln
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:73879 )

N • hippocampal-dependent behavior is normal in spatial learning, Morris water maze, and radial-maze tests

abnormal active avoidance behavior ( J:73879 )

• mice fail to exhibit as much success learning to avoid the electric shock compared with wild-type mice

impaired contextual conditioning behavior ( J:73879 )

• in a one-trial inhibitory avoidance, mice forget to avoid the dark chamber after 24 hours unlike wild-type mice

abnormal long-term spatial reference memory ( J:73879 )

• in fear conditioning tests, mice exhibit diminished long-term memory compared with wild-type mice

• however, short-term memory is normal

nervous system

nervous system phenotype ( J:73879 )

N • brain morphology is normal

impaired synaptic plasticity ( J:73879 )

• long-lasting plasticity is absent

abnormal excitatory postsynaptic potential ( J:73879 )

• larger than in wild-type mice in the amygdala and CA1 hippocampus

reduced long-term potentiation ( J:73879 )

• following delivery of 3 trains of stimulation of 10-burst theta frequency, mice fail to exhibit enhancement of LTP unlike wild-type mice