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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Agtr1btm1Cof
targeted mutation 1, Thomas M Coffman
MGI:2157020
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Hprt1tm1(Ggt1-Agtr1)Cof/Y
involves: 129P2/OlaHsd MGI:3051600
cx2
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6 MGI:4454284
cx3
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6 MGI:4454285
cx4
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
involves: 129P2/OlaHsd * C57BL/6 MGI:4454286
cx5
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6 MGI:4454287
cx6
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6 MGI:4454288


Genotype
MGI:3051600
cx1
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Hprt1tm1(Ggt1-Agtr1)Cof/Y
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation (0 available); any Hprt1 mutation (1279 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• renin levels reduced by 70% from levels found in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• renin levels essentially normal

renal/urinary system
• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved

growth/size/body
• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved




Genotype
MGI:4454284
cx2
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

cardiovascular system
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
• compared with wild-type mice and Agtr1atm1Unc homozygotes

homeostasis/metabolism
• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• endothelin 1 (Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and fail to exhibit any chronotropic response compared with similarly treated wild-type mice

renal/urinary system
• in some mice
• compared with wild type mice and Agtr1atm1Unc Agtr1btm1Cof double homozygotes

growth/size/body
• compared with wild-type mice that is not as severe as in Agtr1atm1Unc Agtr1btm1Cof double homozygotes




Genotype
MGI:4454285
cx3
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

cardiovascular system
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
• compared with wild-type mice and Agtr1atm1Unc homozygotes

homeostasis/metabolism
• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• endothelin 1 (Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and fail to exhibit any chronotropic response compared with similarly treated wild-type mice

renal/urinary system
• in some mice
• compared with wild type mice and Agtr1atm1Unc Agtr1btm1Cof double homozygotes

growth/size/body
• compared with wild-type mice that is not as severe as in Agtr1atm1Unc Agtr1btm1Cof double homozygotes




Genotype
MGI:4454286
cx4
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

cardiovascular system
• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice

homeostasis/metabolism
• serum levels of Ang II are increased compared to in wild-type mice and Agtr1btm1Cof homozygotes
• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
• however, PE-treated mice exhibit a negative chronotropic response as in wild-type mice

renal/urinary system
• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice
• mice exhibit cystic dilated cavities unlike wild-type mice
• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice
• severely dilated Bowman's space
• multifocal and focally extensive glomeruli atrophy
• partially dilated tubular lumina unlike in wild-type mice

growth/size/body
• mice exhibit cystic dilated cavities unlike wild-type mice

immune system
• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice




Genotype
MGI:4454287
cx5
Allelic
Composition
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice exhibit hyperemic capillary loops unlike wild-type mice
• however, glomeruli are well perfused with distinct basal membranes

cardiovascular system

growth/size/body




Genotype
MGI:4454288
cx6
Allelic
Composition
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice exhibit hyperemic capillary loops unlike wild-type mice
• however, glomeruli are well perfused with distinct basal membranes

cardiovascular system

growth/size/body





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory