All Phenotypes Lyn<tm1Ard> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lyn^tm1Ard
targeted mutation 1, Ashley R Dunn
MGI:2157129

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyn^tm1Ard/Lyn^tm1Ard	B6.129P2-Lyn^tm1Ard	MGI:3832565
hm2	Lyn^tm1Ard/Lyn^tm1Ard	involves: 129P2/OlaHsd	MGI:3767995
cx3	Blk^tm1Tara/Blk^tm1Tara Fyn^tm1Sor/Fyn^tm1Sor Lyn^tm1Ard/Lyn^tm1Ard	either: B6.129-Lyn^tm1Ard Fyn^tm1Sor Blk^tm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)	MGI:3696475
cx4	Kit^W-sh/Kit^W-sh Lyn^tm1Ard/Lyn^tm1Ard	involves: 101 * 129P2/OlaHsd * C3H/HeH	MGI:4462257
cx5	Il4^tm1Kopf/Il4^tm1Kopf Lyn^tm1Ard/Lyn^tm1Ard	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:4462259
cx6	Igh-7^tm1Led/Igh-7^tm1Led Lyn^tm1Ard/Lyn^tm1Ard	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:4462262
cx7	Lyn^tm1Ard/Lyn^tm1Ard Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852084
cx8	Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852085
cx9	Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852087
cx10	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852089
cx11	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852091

Allelic Composition	Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	B6.129P2-Lyn^tm1Ard

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

peritoneal inflammation ( J:144799 )

• there is about a doubling in the number of T cells found in the peritoneum

abnormal myelopoiesis ( J:144799 )

• myelopoiesis is greatly enhanced in these mice

• there is a significant increase in the number of colonies generated by bone marrow cells or splenocytes in response to in vitro culturing with GM-CSF, M-CSF, or IL-3

increased T cell number ( J:144799 )

• there is about a doubling in the number of T cells found in the peritoneum

abnormal B cell morphology ( J:144799 )

• B cells express lower levels of CD21 and higher levels of CD23 on the cell surface compared to controls

decreased transitional stage B cell number ( J:144799 )

• profound reduction in transitional stage-2 B cells

decreased follicular B cell number ( J:144799 )

• about a five-fold reduction in follicular B cells

decreased marginal zone B cell number ( J:144799 )

• profound reduction in marginal zone B cells

spleen hypoplasia ( J:144799 )

• spleen cellularity is reduced by more than half due to B cell lymphopenia

abnormal B cell activation ( J:144799 )

• significant expression of MHCII complexes by circulating B cells suggest these B cells are in an activated state

• B cells have enhanced calcium flux upon activation

increased anti-nuclear antigen antibody level ( J:144799 )

• auto-antibodies of the IgA, IgG IgM classes develop as the mice age

increased anti-double stranded DNA antibody level ( J:144799 )

• mice develop anti-DS DNA IgG antibodies as they age with high levels detectable in all mice by 20 weeks of age

glomerulonephritis ( J:144799 )

• all mice have immunoglobulin complex deposition in the kidney by 8 weeks of age

• 83% of mice also have C3 complement deposition in the kidney

• severe glomerulonephritis occurs in these mice by one year of age

renal/urinary system

glomerulonephritis ( J:144799 )

• all mice have immunoglobulin complex deposition in the kidney by 8 weeks of age

• 83% of mice also have C3 complement deposition in the kidney

• severe glomerulonephritis occurs in these mice by one year of age

renal glomerular immunoglobulin deposits ( J:144799 )

• immunoglobulin complex deposition in the kidney by 8 weeks of age

• 83% of mice also have C3 complement deposition in the kidney

digestive/alimentary system

peritoneal inflammation ( J:144799 )

• there is about a doubling in the number of T cells found in the peritoneum

hematopoietic system

abnormal myelopoiesis ( J:144799 )

• myelopoiesis is greatly enhanced in these mice

• there is a significant increase in the number of colonies generated by bone marrow cells or splenocytes in response to in vitro culturing with GM-CSF, M-CSF, or IL-3

increased T cell number ( J:144799 )

• there is about a doubling in the number of T cells found in the peritoneum

abnormal B cell morphology ( J:144799 )

• B cells express lower levels of CD21 and higher levels of CD23 on the cell surface compared to controls

decreased transitional stage B cell number ( J:144799 )

• profound reduction in transitional stage-2 B cells

decreased follicular B cell number ( J:144799 )

• about a five-fold reduction in follicular B cells

decreased marginal zone B cell number ( J:144799 )

• profound reduction in marginal zone B cells

spleen hypoplasia ( J:144799 )

• spleen cellularity is reduced by more than half due to B cell lymphopenia

abnormal B cell activation ( J:144799 )

• significant expression of MHCII complexes by circulating B cells suggest these B cells are in an activated state

• B cells have enhanced calcium flux upon activation

Allelic Composition	Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

• 20% of mice greater than 1 year of age exhibit severe splenomegaly with partial to complete replacement of red and white pulp with myelomonocytic cells that are often centers of extramedullary hematopoiesis

extramedullary hematopoiesis ( J:72269 )

• red and white pulp are often replaced with of red and white pulp with myelomonocytic cells that are often centers of extramedullary hematopoiesis

• myelomonocytic cells often accumulate in other organs and on the surface of the ears, tails and legs

increased basophil cell number ( J:161523 )

• in cervical and inguinal lymph nodes and spleen

increased mast cell number ( J:161523 )

• in the peritoneum

increased neutrophil cell number ( J:72269 )

• mice exhibit decreased platelet numbers that becomes more pronounced with age (at 6 to 8 weeks in peripheral blood, 1089+/-242 per ul compared to 609+/-207 per ul in wild-type mice; at 52 to 58 weeks in peripheral blood, 2540+/-1050 per ul compared to 1264+/-434 per ul in wild-type mice)

thrombocytopenia ( J:72269 )

decreased spleen red pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

decreased spleen white pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

increased basophil cell number ( J:161523 )

• in cervical and inguinal lymph nodes and spleen

increased mast cell number ( J:161523 )

• in the peritoneum

increased neutrophil cell number ( J:72269 )

decreased spleen red pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

decreased spleen white pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

abnormal level of surface class II molecules ( J:161523 )

• basophils show high MHC II expression

increased anti-nuclear antigen antibody level ( J:161523 )

• of IgE isotype

increased anti-double stranded DNA antibody level ( J:161523 )

• of IgE isotype

glomerulonephritis ( J:161523 )

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

renal/urinary system

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

glomerulonephritis ( J:161523 )

growth/size/body

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:161523

Allelic Composition	Blk^tm1Tara/Blk^tm1Tara Fyn^tm1Sor/Fyn^tm1Sor Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	either: B6.129-Lyn^tm1Ard Fyn^tm1Sor Blk^tm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blk^tm1Tara mutation (1 available); any Blk mutation (28 available)
Fyn^tm1Sor mutation (3 available); any Fyn mutation (39 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:115080 )

• mutant bone marrow is unable to reconstitute B cell development when transferred into lethally irradiated C57BL/6 mice

decreased immature B cell number ( J:115080 )

• exhibit a decrease in immature and B cells in the bone marrow

abnormal pro-B cell differentiation ( J:115080 )

• pro-B cells exhibit impaired anti-Igbeta-induced NF-kappaB activation

arrested B cell differentiation ( J:115080 )

• block in early B cell development

decreased B cell number ( J:115080 )

• impaired development of B cells results in severe B cell lymphopenia characterized by a decrease in B cell numbers in the spleen, lymph nodes, and peritoneal cavity to 1/60-1/100 of wild-type

decreased pre-B cell number ( J:115080 )

• exhibit a reduction in the fraction of viable B220+CD43-IgM- pre-B cells to 10% of wild-type

• 3-fold increase in frequency of apoptotic pre-B cells

hematopoietic system

abnormal B cell differentiation ( J:115080 )

• mutant bone marrow is unable to reconstitute B cell development when transferred into lethally irradiated C57BL/6 mice

decreased immature B cell number ( J:115080 )

• exhibit a decrease in immature and B cells in the bone marrow

abnormal pro-B cell differentiation ( J:115080 )

• pro-B cells exhibit impaired anti-Igbeta-induced NF-kappaB activation

arrested B cell differentiation ( J:115080 )

• block in early B cell development

decreased B cell number ( J:115080 )

• impaired development of B cells results in severe B cell lymphopenia characterized by a decrease in B cell numbers in the spleen, lymph nodes, and peritoneal cavity to 1/60-1/100 of wild-type

decreased pre-B cell number ( J:115080 )

• exhibit a reduction in the fraction of viable B220+CD43-IgM- pre-B cells to 10% of wild-type

• 3-fold increase in frequency of apoptotic pre-B cells

Allelic Composition	Kit^W-sh/Kit^W-sh Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 101 * 129P2/OlaHsd * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-sh mutation (11 available); any Kit mutation (182 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• of IgE isotype

increased anti-double stranded DNA antibody level ( J:161523 )

• of IgE isotype

glomerulonephritis ( J:161523 )

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

renal/urinary system

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

glomerulonephritis ( J:161523 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:161523

Allelic Composition	Il4^tm1Kopf/Il4^tm1Kopf Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Kopf mutation (4 available); any Il4 mutation (46 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

increased mast cell number ( J:161523 )

• in the peritoneum

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

decreased IgE level ( J:161523 )

decreased IgG1 level ( J:161523 )

increased IgG2a level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

increased mast cell number ( J:161523 )

• in the peritoneum

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

decreased IgE level ( J:161523 )

decreased IgG1 level ( J:161523 )

increased IgG2a level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

increased anti-double stranded DNA antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

Allelic Composition	Igh-7^tm1Led/Igh-7^tm1Led Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-7^tm1Led mutation (1 available); any Igh-7 mutation (1 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

increased anti-double stranded DNA antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

Allelic Composition	Lyn^tm1Ard/Lyn^tm1Ard Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is blocked at the immature B cell stage instead of anergy inducation in mature B cells as occurs with wild-type bone marrow

abnormal mature B cell morphology ( J:110531 )

• mature B cells have 4-5 lower sIgM levels on their surface

absent B-1 B cells ( J:110531 )

• B1 B cells are absent in these mice

abnormal B cell activation ( J:110531 )

• B cells have altered kinetics of calcium fluxing upon BCR engagement with delayed influx but an ultimately higher peak intracellular concentration

increased IgM level ( J:110531 )

• hypersecretion of the transgenic IgM antibody occurs in these mice

hematopoietic system

abnormal B cell negative selection ( J:110531 )

abnormal mature B cell morphology ( J:110531 )

• mature B cells have 4-5 lower sIgM levels on their surface

absent B-1 B cells ( J:110531 )

• B1 B cells are absent in these mice

abnormal B cell activation ( J:110531 )

• B cells have altered kinetics of calcium fluxing upon BCR engagement with delayed influx but an ultimately higher peak intracellular concentration

increased IgM level ( J:110531 )

• hypersecretion of the transgenic IgM antibody occurs in these mice

Allelic Composition	Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 2-fold lower surface IgM levels

hematopoietic system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 2-fold lower surface IgM levels

Allelic Composition	Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Ptpn6^me-v mutation (3 available); any Ptpn6 mutation (49 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 4-fold lower surface IgM levels

immune system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 4-fold lower surface IgM levels

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm1Eac mutation (1 available); any Cd22 mutation (64 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Ptpn6^me-v mutation (3 available); any Ptpn6 mutation (49 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is only 15% of controls

increased IgM level ( J:110531 )

• half the mice have a 15-fold increase in Hel-specific serum IgM

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is only 15% of controls

increased IgM level ( J:110531 )

• half the mice have a 15-fold increase in Hel-specific serum IgM

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24