All Phenotypes Lyn<tm1Ard> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lyn^tm1Ard
targeted mutation 1, Ashley R Dunn
MGI:2157129

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyn^tm1Ard/Lyn^tm1Ard	B6.129P2-Lyn^tm1Ard	MGI:3832565
hm2	Lyn^tm1Ard/Lyn^tm1Ard	involves: 129P2/OlaHsd	MGI:3767995
cx3	Blk^tm1Tara/Blk^tm1Tara Fyn^tm1Sor/Fyn^tm1Sor Lyn^tm1Ard/Lyn^tm1Ard	either: B6.129-Lyn^tm1Ard Fyn^tm1Sor Blk^tm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)	MGI:3696475
cx4	Kit^W-sh/Kit^W-sh Lyn^tm1Ard/Lyn^tm1Ard	involves: 101 * 129P2/OlaHsd * C3H/HeH	MGI:4462257
cx5	Il4^tm1Kopf/Il4^tm1Kopf Lyn^tm1Ard/Lyn^tm1Ard	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:4462259
cx6	Igh-7^tm1Led/Igh-7^tm1Led Lyn^tm1Ard/Lyn^tm1Ard	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:4462262
cx7	Lyn^tm1Ard/Lyn^tm1Ard Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852084
cx8	Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852085
cx9	Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852087
cx10	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852089
cx11	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852091

Allelic Composition	Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	B6.129P2-Lyn^tm1Ard

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

peritoneal inflammation ( J:144799 )

• there is about a doubling in the number of T cells found in the peritoneum

abnormal myelopoiesis ( J:144799 )

• myelopoiesis is greatly enhanced in these mice

• there is a significant increase in the number of colonies generated by bone marrow cells or splenocytes in response to in vitro culturing with GM-CSF, M-CSF, or IL-3

increased T cell number ( J:144799 )

• there is about a doubling in the number of T cells found in the peritoneum

abnormal B cell morphology ( J:144799 )

• B cells express lower levels of CD21 and higher levels of CD23 on the cell surface compared to controls

decreased transitional stage B cell number ( J:144799 )

• profound reduction in transitional stage-2 B cells

decreased follicular B cell number ( J:144799 )

• about a five-fold reduction in follicular B cells

decreased marginal zone B cell number ( J:144799 )

• profound reduction in marginal zone B cells

spleen hypoplasia ( J:144799 )

• spleen cellularity is reduced by more than half due to B cell lymphopenia

abnormal B cell activation ( J:144799 )

• significant expression of MHCII complexes by circulating B cells suggest these B cells are in an activated state

• B cells have enhanced calcium flux upon activation

increased anti-nuclear antigen antibody level ( J:144799 )

• auto-antibodies of the IgA, IgG IgM classes develop as the mice age

increased anti-double stranded DNA antibody level ( J:144799 )

• mice develop anti-DS DNA IgG antibodies as they age with high levels detectable in all mice by 20 weeks of age

glomerulonephritis ( J:144799 )

• all mice have immunoglobulin complex deposition in the kidney by 8 weeks of age

• 83% of mice also have C3 complement deposition in the kidney

• severe glomerulonephritis occurs in these mice by one year of age

renal/urinary system

glomerulonephritis ( J:144799 )

• all mice have immunoglobulin complex deposition in the kidney by 8 weeks of age

• 83% of mice also have C3 complement deposition in the kidney

• severe glomerulonephritis occurs in these mice by one year of age

renal glomerular immunoglobulin deposits ( J:144799 )

• immunoglobulin complex deposition in the kidney by 8 weeks of age

• 83% of mice also have C3 complement deposition in the kidney

digestive/alimentary system

peritoneal inflammation ( J:144799 )

• there is about a doubling in the number of T cells found in the peritoneum

hematopoietic system

abnormal myelopoiesis ( J:144799 )

• myelopoiesis is greatly enhanced in these mice

• there is a significant increase in the number of colonies generated by bone marrow cells or splenocytes in response to in vitro culturing with GM-CSF, M-CSF, or IL-3

increased T cell number ( J:144799 )

• there is about a doubling in the number of T cells found in the peritoneum

abnormal B cell morphology ( J:144799 )

• B cells express lower levels of CD21 and higher levels of CD23 on the cell surface compared to controls

decreased transitional stage B cell number ( J:144799 )

• profound reduction in transitional stage-2 B cells

decreased follicular B cell number ( J:144799 )

• about a five-fold reduction in follicular B cells

decreased marginal zone B cell number ( J:144799 )

• profound reduction in marginal zone B cells

spleen hypoplasia ( J:144799 )

• spleen cellularity is reduced by more than half due to B cell lymphopenia

abnormal B cell activation ( J:144799 )

• significant expression of MHCII complexes by circulating B cells suggest these B cells are in an activated state

• B cells have enhanced calcium flux upon activation

Allelic Composition	Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

• 20% of mice greater than 1 year of age exhibit severe splenomegaly with partial to complete replacement of red and white pulp with myelomonocytic cells that are often centers of extramedullary hematopoiesis

extramedullary hematopoiesis ( J:72269 )

• red and white pulp are often replaced with of red and white pulp with myelomonocytic cells that are often centers of extramedullary hematopoiesis

• myelomonocytic cells often accumulate in other organs and on the surface of the ears, tails and legs

increased basophil cell number ( J:161523 )

• in cervical and inguinal lymph nodes and spleen

increased mast cell number ( J:161523 )

• in the peritoneum

increased neutrophil cell number ( J:72269 )

• mice exhibit decreased platelet numbers that becomes more pronounced with age (at 6 to 8 weeks in peripheral blood, 1089+/-242 per ul compared to 609+/-207 per ul in wild-type mice; at 52 to 58 weeks in peripheral blood, 2540+/-1050 per ul compared to 1264+/-434 per ul in wild-type mice)

thrombocytopenia ( J:72269 )

decreased spleen red pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

decreased spleen white pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

increased basophil cell number ( J:161523 )

• in cervical and inguinal lymph nodes and spleen

increased mast cell number ( J:161523 )

• in the peritoneum

increased neutrophil cell number ( J:72269 )

decreased spleen red pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

decreased spleen white pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

abnormal level of surface class II molecules ( J:161523 )

• basophils show high MHC II expression

increased anti-nuclear antigen antibody level ( J:161523 )

• of IgE isotype

increased anti-double stranded DNA antibody level ( J:161523 )

• of IgE isotype

glomerulonephritis ( J:161523 )

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

renal/urinary system

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

glomerulonephritis ( J:161523 )

growth/size/body

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:161523

Allelic Composition	Blk^tm1Tara/Blk^tm1Tara Fyn^tm1Sor/Fyn^tm1Sor Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	either: B6.129-Lyn^tm1Ard Fyn^tm1Sor Blk^tm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blk^tm1Tara mutation (1 available); any Blk mutation (28 available)
Fyn^tm1Sor mutation (3 available); any Fyn mutation (39 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:115080 )

• mutant bone marrow is unable to reconstitute B cell development when transferred into lethally irradiated C57BL/6 mice

decreased immature B cell number ( J:115080 )

• exhibit a decrease in immature and B cells in the bone marrow

abnormal pro-B cell differentiation ( J:115080 )

• pro-B cells exhibit impaired anti-Igbeta-induced NF-kappaB activation

arrested B cell differentiation ( J:115080 )

• block in early B cell development

decreased B cell number ( J:115080 )

• impaired development of B cells results in severe B cell lymphopenia characterized by a decrease in B cell numbers in the spleen, lymph nodes, and peritoneal cavity to 1/60-1/100 of wild-type

decreased pre-B cell number ( J:115080 )

• exhibit a reduction in the fraction of viable B220+CD43-IgM- pre-B cells to 10% of wild-type

• 3-fold increase in frequency of apoptotic pre-B cells

hematopoietic system

abnormal B cell differentiation ( J:115080 )

• mutant bone marrow is unable to reconstitute B cell development when transferred into lethally irradiated C57BL/6 mice

decreased immature B cell number ( J:115080 )

• exhibit a decrease in immature and B cells in the bone marrow

abnormal pro-B cell differentiation ( J:115080 )

• pro-B cells exhibit impaired anti-Igbeta-induced NF-kappaB activation

arrested B cell differentiation ( J:115080 )

• block in early B cell development

decreased B cell number ( J:115080 )

• impaired development of B cells results in severe B cell lymphopenia characterized by a decrease in B cell numbers in the spleen, lymph nodes, and peritoneal cavity to 1/60-1/100 of wild-type

decreased pre-B cell number ( J:115080 )

• exhibit a reduction in the fraction of viable B220+CD43-IgM- pre-B cells to 10% of wild-type

• 3-fold increase in frequency of apoptotic pre-B cells

Allelic Composition	Kit^W-sh/Kit^W-sh Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 101 * 129P2/OlaHsd * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-sh mutation (11 available); any Kit mutation (182 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• of IgE isotype

increased anti-double stranded DNA antibody level ( J:161523 )

• of IgE isotype

glomerulonephritis ( J:161523 )

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

renal/urinary system

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

glomerulonephritis ( J:161523 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:161523

Allelic Composition	Il4^tm1Kopf/Il4^tm1Kopf Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Kopf mutation (4 available); any Il4 mutation (46 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

increased mast cell number ( J:161523 )

• in the peritoneum

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

decreased IgE level ( J:161523 )

decreased IgG1 level ( J:161523 )

increased IgG2a level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

increased mast cell number ( J:161523 )

• in the peritoneum

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

decreased IgE level ( J:161523 )

decreased IgG1 level ( J:161523 )

increased IgG2a level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

increased anti-double stranded DNA antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

Allelic Composition	Igh-7^tm1Led/Igh-7^tm1Led Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-7^tm1Led mutation (1 available); any Igh-7 mutation (1 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

increased anti-double stranded DNA antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

Allelic Composition	Lyn^tm1Ard/Lyn^tm1Ard Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is blocked at the immature B cell stage instead of anergy inducation in mature B cells as occurs with wild-type bone marrow

abnormal mature B cell morphology ( J:110531 )

• mature B cells have 4-5 lower sIgM levels on their surface

absent B-1 B cells ( J:110531 )

• B1 B cells are absent in these mice

abnormal B cell activation ( J:110531 )

• B cells have altered kinetics of calcium fluxing upon BCR engagement with delayed influx but an ultimately higher peak intracellular concentration

increased IgM level ( J:110531 )

• hypersecretion of the transgenic IgM antibody occurs in these mice

hematopoietic system

abnormal B cell negative selection ( J:110531 )

abnormal mature B cell morphology ( J:110531 )

• mature B cells have 4-5 lower sIgM levels on their surface

absent B-1 B cells ( J:110531 )

• B1 B cells are absent in these mice

abnormal B cell activation ( J:110531 )

• B cells have altered kinetics of calcium fluxing upon BCR engagement with delayed influx but an ultimately higher peak intracellular concentration

increased IgM level ( J:110531 )

• hypersecretion of the transgenic IgM antibody occurs in these mice

Allelic Composition	Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 2-fold lower surface IgM levels

hematopoietic system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 2-fold lower surface IgM levels

Allelic Composition	Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Ptpn6^me-v mutation (3 available); any Ptpn6 mutation (49 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 4-fold lower surface IgM levels

immune system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 4-fold lower surface IgM levels

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm1Eac mutation (1 available); any Cd22 mutation (64 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Ptpn6^me-v mutation (3 available); any Ptpn6 mutation (49 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is only 15% of controls

increased IgM level ( J:110531 )

• half the mice have a 15-fold increase in Hel-specific serum IgM

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is only 15% of controls

increased IgM level ( J:110531 )

• half the mice have a 15-fold increase in Hel-specific serum IgM

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

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