All Phenotypes Apoa2<tm1Bres> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apoa2^tm1Bres
targeted mutation 1, Jan L Breslow
MGI:2157148

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoa2^tm1Bres/Apoa2^tm1Bres	involves: 129S4/SvJae	MGI:2655394
cx2	Apoa2^tm1Bres/Apoa2^tm1Bres Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:2655397
cx3	Apoa2^tm1Bres/Apoa2⁺ Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:2655399
cx4	Apoa1^tm1Bres/Apoa1^tm1Bres Apoa2^tm1Bres/Apoa2^tm1Bres	involves: 129S4/SvJae * C57BL/6	MGI:3783891

Allelic Composition	Apoa2^tm1Bres/Apoa2^tm1Bres
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa2^tm1Bres mutation (5 available); any Apoa2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:37250 )

• 11% decrease in fasting glucose levels

decreased circulating insulin level ( J:37250 )

• 32% decrease in fasting insulin levels

decreased circulating free fatty acids level ( J:37250 )

• 58% and 32% decrease in fasted and fed FFA levels, respectively

abnormal cholesterol homeostasis ( J:37250 )

• increase in fractional catabolic rate and decrease in transport rate of HDL cholesterol ester

decreased circulating cholesterol level ( J:37250 )

• 67% and 52% reduction in cholesterol levels in fasted and fed state, respectively

decreased circulating HDL cholesterol level ( J:37250 )

• 73% and 64% reduction in HDL cholesterol levels in fasted and fed state, respectively, reduced HDL particle size

Allelic Composition	Apoa2^tm1Bres/Apoa2^tm1Bres Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa2^tm1Bres mutation (5 available); any Apoa2 mutation (20 available)
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:37250 )

• 66% decrease in cholesterol levels compared to single Apoe homozygotes

decreased circulating HDL cholesterol level ( J:37250 )

Allelic Composition	Apoa2^tm1Bres/Apoa2⁺ Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:37250 )

• 34% decrease in cholesterol levels compared to single Apoe homozygotes

Allelic Composition	Apoa1^tm1Bres/Apoa1^tm1Bres Apoa2^tm1Bres/Apoa2^tm1Bres
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1^tm1Bres mutation (0 available); any Apoa1 mutation (15 available)
Apoa2^tm1Bres mutation (5 available); any Apoa2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a further 50% or more reduction in HDL-C levels compared to in Apoa1^tm1Bres homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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