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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1Holl
targeted mutation 1, Monica Hollstein
MGI:2157167
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1Holl/Trp53tm1Holl involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3762534
hm2
 		Trp53tm1Holl/Trp53tm1Holl involves: 129P2/OlaHsd MGI:3762543
ht3
 		Trp53tm1Holl/Trp53tm2Holl involves: 129P2/OlaHsd MGI:3803611
ht4
 		Trp53tm1Holl/Trp53tm7.1Xu involves: 129P2/OlaHsd MGI:4456126


Genotype
MGI:3762534
hm1
Allelic
Composition		 Trp53tm1Holl/Trp53tm1Holl
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Holl mutation (3 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:68918 )
N
• unlike in p53 null mice, p53 localization to UV irradiation and gamma-radiation induced apoptosis are normal

neoplasm
neoplasm ( J:68918 )
N
• unlike in p53 null mice, no tumors develop by 8 months of age




Genotype
MGI:3762543
hm2
Allelic
Composition		 Trp53tm1Holl/Trp53tm1Holl
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Holl mutation (3 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:126497 )
N
• irradiated mouse embryonic fibroblasts do not develop chromosomal translocations




Genotype
MGI:3803611
ht3
Allelic
Composition		 Trp53tm1Holl/Trp53tm2Holl
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Holl mutation (3 available); any Trp53 mutation (240 available)
Trp53tm2Holl mutation (1 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:135505 )
• mouse embryonic fibroblasts (MEFs) generated from embryos immortalize at the same rate as wild-type MEFs




Genotype
MGI:4456126
ht4
Allelic
Composition		 Trp53tm1Holl/Trp53tm7.1Xu
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Holl mutation (3 available); any Trp53 mutation (240 available)
Trp53tm7.1Xu mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:160414 )
• following irradiation, thymocyte apoptosis is decreased compared to in wild-type mice but not as much as in homozygous Trp53tm7Xu thymocytes

neoplasm
increased tumor incidence ( J:160414 )
• tumorigenesis is partially rescued compared to in Trp53tm7Xu homozygotes with delayed onset and reduced penetrance

hematopoietic system
decreased thymocyte apoptosis ( J:160414 )
• following irradiation, thymocyte apoptosis is decreased compared to in wild-type mice but not as much as in homozygous Trp53tm7Xu thymocytes

cellular
decreased thymocyte apoptosis ( J:160414 )
• following irradiation, thymocyte apoptosis is decreased compared to in wild-type mice but not as much as in homozygous Trp53tm7Xu thymocytes

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:160414 )
• following irradiation, thymocyte apoptosis is decreased compared to in wild-type mice but not as much as in homozygous Trp53tm7Xu thymocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory