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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apobec1tm1Ddsn
targeted mutation 1, Nicholas O Davidson
MGI:2157186
Summary 5 genotypes


Genotype
MGI:3623802
hm1
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Genetic
Background		 B6.129S4-Apobec1tm1Ddsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid homeostasis ( J:108052 )
• chylomicron particles larger in size than in controls
abnormal triglyceride level ( J:108052 )
• accumulation of plasma triglycerides as a result of oral lipid challenge reduced in comparison to controls




Genotype
MGI:3623801
hm2
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:32731 )
• plasma triglyceride levels, cholesterol levels and cholesterol distribution in particular were normal




Genotype
MGI:4367102
cx3
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129-Apobec1tm1Ddsn Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (28 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating LDL cholesterol level ( J:132734 )
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction
abnormal blood coagulation ( J:132734 )
• elevated thrombin and antithrombin levels
decreased partial thromboplastin time ( J:132734 )
• shortened activated thromboplastin times
decreased prothrombin time ( J:132734 )
• shortened prothrombin times

cardiovascular system
atherosclerotic lesions ( J:132734 )
• plaque surface area increases from 24 to 72 weeks of age
• plaques composed of a fibrous cap over a foam cell core
• multilayered smooth muscle cell regions associated with collagen deposition at 24 weeks
• smooth muscle cell numbers diminished after 36 weeks
• collagen throughout the plaque core at 48 weeks




Genotype
MGI:4367109
cx4
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Fggtm1Fjc/Fggtm1Fjc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (28 available)
Fggtm1Fjc mutation (0 available); any Fgg mutation (30 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:135942 )
• display better survival to 3 weeks than do mice only deficient for Fgg

homeostasis/metabolism
increased circulating LDL cholesterol level ( J:132734 )
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction
abnormal blood coagulation ( J:132734 )
• thrombin and antithrombin levels very highly elevated

cardiovascular system
atherosclerotic lesions ( J:132734 )
• plaque surface area increases beyond what is seen in double homozygotes lacking fibrinogen gamma chain deficiency
• fibrous cap thinner than is seen in double homozygotes lacking fibrinogen gamma chain deficiency
• collagen deposition in plaques develops more rapidly than in double homozygotes lacking fibrinogen gamma chain deficiency




Genotype
MGI:4367101
cx5
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (28 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating cholesterol level ( J:49125 )
• total cholesterol levels are higher in males than females
• on a high fat diet total cholesterol reaches 1600 mg/dl by 8 weeks
increased circulating LDL cholesterol level ( J:49125 )
• elevated in both sexes but higher in males than females

cardiovascular system
atherosclerotic lesions ( J:49125 )
• extensive lesions along the length of the aorta at 8 months
• lesions are somewhat more extensive in males but otherwise the sexes are similar
• on a high fat diet lesions cover 9% of the aorta surface by 8 weeks

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
familial hypercholesterolemia DOID:13810 OMIM:143890
 J:49125




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory