Allele Symbol Allele Name Allele ID |
Apobec1tm1Chan targeted mutation 1, Lawrence Chan MGI:2157210 |
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Summary |
4 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• circulating VLDL/LDL cholesterol levels are decreased compared to in Apoetm1Unc homozygotes
• circulating VLDL/LDL cholesterol levels are increased compared to in Apobec1tm1Chan homozygotes and wild-type mice
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• when fed a chow, mice exhibit decreased total serum cholesterol compared with Apoetm1Unc homozygotes
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• when fed a chow or a Western-type diet for 2 or 4 weeks, mice exhibit decreased total serum cholesterol compared with Apobec1tm1Chan homozygotes and wild-type mice
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• when fed a chow diet or a Western-type diet for 2 or 4 weeks, serum triglyceride is higher than in wild-type mice
• when fed a Western-type diet for 2 or 4 weeks, mice exhibit increased serum triglyceride compared with Apobec1tm1Chan or Apoetm1Unc homozygotes
• when fed a Western-type diet for 10 weeks, mice exhibit increased serum triglyceride compared with Apoetm1Unc homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• circulating VLDL/LDL cholesterol levels are increased compared to in Ldlrtm1Her homozygotes, Apobec1tm1Chan homozygotes, and wild-type mice
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• when fed a chow diet or Western-type diet for 2 and 4 weeks, mice exhibit increased serum cholesterol levels compared with Ldlrtm1Her homozygotes, Apobec1tm1Chan homozygotes, and wild-type mice
• when fed a Western-type diet for 14 weeks, mice exhibit higher serum cholesterol levels compared with Ldlrtm1Her homozygotes
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• when fed a Western-type diet for 2 weeks, serum triglyceride levels are less than in Ldlrtm1Her homozygotes
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• when fed a chow diet or a high fat diet for 2 and 4 weeks, mice exhibit a decrease in serum triglyceride levels compared with Apobec1tm1Chan homozygotes and wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• circulating VLDL/LDL cholesterol levels are increased compared to in Tg(CETP)5203Tall mice, Apobec1tm1Chan homozygotes, and wild-type mice
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• compared to in Apobec1tm1Chan homozygotes and wild-type mice
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• after 4 and 16 weeks on a Western-type diet compared to in Tg(CETP)5203Tall mice
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• after 2 on a Western-type diet compared to in Apobec1tm1Chan homozygotes
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• mice exhibit increased serum triglyceride levels compared with wild-type mice
• after 2 on a Western-type diet, mice exhibit an increase in serum triglyceride levels compared with Tg(CETP)5203Tall mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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