Phenotypes associated with this allele

• Allele Symbol: Apoc1^tm1Lmh
• Allele Name: targeted mutation 1, Louis M Havekes
• Allele ID: MGI:2157218
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoc1^tm1Lmh/Apoc1^tm1Lmh	involves: 129P2/OlaHsd * C57BL/6	MGI:3697242
cx2	Apoc1^tm1Lmh/Apoc1^tm1Lmh Tg(CETP)5203Tall/0	involves: 129P2/OlaHsd * C57BL/6 * CBA/J	MGI:3697301

Genotype
MGI:3697242

hm1

• Allelic Composition: Apoc1^tm1Lmh/Apoc1^tm1Lmh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:117482 )

• hepatic levels are markedly increased (by 31.4%) compared to controls as result of 57.8% increase in cholesteryl ester content

abnormal circulating cholesterol level ( J:22858 )

• total circulating cholesterol level is normal, but relative amount in VLDL + LDL-sized fraction is doubled compared to wild-type mice on HFC diet

increased circulating triglyceride level ( J:22858 )

• total serum triacylglycerols are slightly increased compared to controls; this increase is confined to the VLDL + LDL -sized fractions

• after 3 weeks on a mild high-fat/cholesterol diet (HFC), serum levels are elevated 1.6 fold

increased cholesterol level ( J:117482 )

• biliary cholester concentration is higher than in wild-type

increased circulating cholesterol level ( J:22858 )

• when fed a severe high-fat/cholesterol diet (HFC0.5% - contains 1% cholesterol, 0.5% cholate), serum levels are increased to 10.7 mM compared to 6.7 and 5.1 mM in heterozygous and wild-type controls

increased liver triglyceride level ( J:117482 )

• 118.4% increased in hepatic triglyceride levels vs controls

liver/biliary system

increased liver triglyceride level ( J:117482 )

• 118.4% increased in hepatic triglyceride levels vs controls

abnormal bile composition ( J:117482 )

• biliary cholester concentration is higher than in wild-type; cholesterol to bile salt ratio is 37.8% higher than in controls

Genotype
MGI:3697301

cx2

• Allelic Composition: Apoc1^tm1Lmh/Apoc1^tm1Lmh; Tg(CETP)5203Tall/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

homeostasis/metabolism

abnormal lipid level ( J:117482 )

• hepatic level increase is attenuated by transgene expression (by 58.2%) compared to controls

• hepatic cholesteryl ester levels are significantly higher than in wild-type or Tg(CETP)5203Tall controls

increased bile salt level ( J:117482 )

• bile acid level is increased by 19.6% compared to wild-type, Apoc1-deficient, or Tg(CETP)5303Tall mice

increased cholesterol level ( J:117482 )

• biliary cholesterol levels are increased by 87.7% compared to Tg(CETP)5203Tall mice; bile cholesterol is increased compared to Apoc1-deficient or Tg(CETP)5203Tall mice

abnormal phospholipid level ( J:117482 )

• levels are increased compared to wild-type or Tg(CETP)5203Tall mice

increased liver triglyceride level ( J:117482 )

• 302.4% increased in hepatic triglyceride levels vs wild-type or Tg(CETP)5303Tall controls

liver/biliary system

increased liver triglyceride level ( J:117482 )

• 302.4% increased in hepatic triglyceride levels vs wild-type or Tg(CETP)5303Tall controls

abnormal bile composition ( J:117482 )

• all lipids in bile are increased in concentration compared to wild-type levels; cholesterol to bile salt ratio is increased by 54.3% and phospholipids to bile salt ratio is increased 48.1% compared to Tg(CETP)5303Tall mice