Phenotypes associated with this allele

• Allele Symbol: Aldh2^tm1Kaw
• Allele Name: targeted mutation 1, Toshihiro Kawamoto
• Allele ID: MGI:2157245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aldh2^tm1Kaw/Aldh2^tm1Kaw	involves: 129P2/OlaHsd * C57BL/6	MGI:2654875

Genotype
MGI:2654875

hm1

• Allelic Composition: Aldh2^tm1Kaw/Aldh2^tm1Kaw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:63498 )

• in vitro, mutant liver mitochondrial fractions are deficient in methoxyacetaldehyde dehydrogenase (MALD) activity

cellular

abnormal cellular respiration ( J:63498 )

• in vitro, liver mitochondrial fractions derived from homozygous mutant mice display absence of aldehyde oxidation activity toward acetaldehyde (AALD), proprionaldehyde (PALD), and methoxyacetaldehyde (MALD)