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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il1atm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:2157371
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il1atm1Yiw/Il1atm1Yiw involves: 129S1/Sv * 129X1/SvJ MGI:4839924
hm2
 		Il1atm1Yiw/Il1atm1Yiw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4360500
cx3
 		Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw 		involves: 129S1/Sv * 129X1/SvJ * BALB/c MGI:4360919
cx4
 		Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4360503
cx5
 		Il1atm1Yiw/Il1atm1Yiw
Nlrp1aNeut1/Nlrp1aNeut1 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5474284
cx6
 		Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw
Tg(KRT14-CASP1)1Miz/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5563673


Genotype
MGI:4839924
hm1
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor vascularization ( J:82394 )
• angiogenesis in mice injected with B16 melanoma cells is reduced compared to in similarly treated wild-type mice
decreased metastatic potential ( J:82394 )
• following injection of B16 melanoma cells or mammary cancer tumor DA/3, no metastatic tumors are observed unlike in similarly treated wild-type mice

cardiovascular system
cardiovascular system phenotype ( J:107324 )
N
• mice exhibit normal response to carotid ligation
abnormal tumor vascularization ( J:82394 )
• angiogenesis in mice injected with B16 melanoma cells is reduced compared to in similarly treated wild-type mice




Genotype
MGI:4360500
hm2
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-1 alpha level ( J:47429 )
• mice do not produce IL-1alpha
decreased interleukin-1 beta secretion ( J:47429 )
• decreased mRNA for IL-1beta is detected in LPS-stimulated macrophages and in the diencephalon of mice administered turpentine

homeostasis/metabolism
decreased circulating interleukin-1 alpha level ( J:47429 )
• mice do not produce IL-1alpha




Genotype
MGI:4360919
cx3
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
Il1btm1Yiw mutation (0 available); any Il1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil recruitment ( J:50775 )
• neutrophil influx into the peritoneal cavity after inoculation with a tumor cell line expressing FasL is about half that of controls

hematopoietic system
impaired neutrophil recruitment ( J:50775 )
• neutrophil influx into the peritoneal cavity after inoculation with a tumor cell line expressing FasL is about half that of controls




Genotype
MGI:4360503
cx4
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
Il1btm1Yiw mutation (0 available); any Il1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-1 alpha level ( J:47429 )
• mice do not produce IL-1alpha
decreased circulating interleukin-1 beta level ( J:47429 )
• mice do not produce IL-1beta
decreased susceptibility to type IV hypersensitivity reaction ( J:165513 )
• mice challenged with FITC and 2,4-dinitrofluorobenzene exhibit attenuated ear swelling compared with similarly treated wild-type mice
• mice challenged with methylated BSA exhibit impaired delayed-type hypersensitivity compared with similarly treated wild-type mice

homeostasis/metabolism
decreased circulating corticosterone level ( J:47429 )
• corticosterone levels 8 hours after injection of turpentine are elevated 2- to 3- fold in wild-type mice but not in mutant mice
• initial rises in corticosterone levels (within first 2 hours of injection) are similar to wild-type
decreased circulating interleukin-1 alpha level ( J:47429 )
• mice do not produce IL-1alpha
decreased circulating interleukin-1 beta level ( J:47429 )
• mice do not produce IL-1beta
impaired febrile response ( J:47429 )
• mice fail to develop a fever in response to turpentine administration while controls have a fever 1 to 4 days after injection




Genotype
MGI:5474284
cx5
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Nlrp1aNeut1/Nlrp1aNeut1
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
Nlrp1aNeut1 mutation (0 available); any Nlrp1a mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:191055 )
• lethal systemic inflammatory disease

hematopoietic system




Genotype
MGI:5563673
cx6
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw
Tg(KRT14-CASP1)1Miz/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
Il1btm1Yiw mutation (0 available); any Il1b mutation (25 available)
Tg(KRT14-CASP1)1Miz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
dermatitis ( J:78602 )
• late onset of skin alterations which are similar to, but milder than, in single Tg(KRT14-CASP1)1Miz mutants

integument
dermatitis ( J:78602 )
• late onset of skin alterations which are similar to, but milder than, in single Tg(KRT14-CASP1)1Miz mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory