About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il1btm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:2157396
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il1btm1Yiw/Il1btm1Yiw involves: 129S1/Sv * 129X1/SvJ MGI:4939417
hm2
 		Il1btm1Yiw/Il1btm1Yiw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4360501
cx3
 		Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw 		involves: 129S1/Sv * 129X1/SvJ * BALB/c MGI:4360919
cx4
 		Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4360503
cx5
 		Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw
Tg(KRT14-CASP1)1Miz/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5563673


Genotype
MGI:4939417
hm1
Allelic
Composition		 Il1btm1Yiw/Il1btm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1btm1Yiw mutation (0 available); any Il1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular wound healing ( J:107324 )
• following carotid ligation, mice exhibit a 3-fold reduction in absolute neointima and 4-fold reduction in lumen area compared with wild-type mice
• however, total vessel area is normal after carotid ligation

homeostasis/metabolism
abnormal vascular wound healing ( J:107324 )
• following carotid ligation, mice exhibit a 3-fold reduction in absolute neointima and 4-fold reduction in lumen area compared with wild-type mice
• however, total vessel area is normal after carotid ligation




Genotype
MGI:4360501
hm2
Allelic
Composition		 Il1btm1Yiw/Il1btm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1btm1Yiw mutation (0 available); any Il1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-1 beta level ( J:47429 )
• mice do not produce IL-1beta

homeostasis/metabolism
decreased circulating corticosterone level ( J:47429 )
• corticosterone levels 8 hours after injection of turpentine are elevated 2- to 3- fold in wild-type mice but not in mutant mice
• initial rises in corticosterone levels (within first 2 hours of injection) are similar to wild-type
decreased circulating interleukin-1 beta level ( J:47429 )
• mice do not produce IL-1beta
impaired febrile response ( J:47429 )
• mice fail to develop a fever in response to turpentine administration while controls have a fever 1 to 4 days after injection




Genotype
MGI:4360919
cx3
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
Il1btm1Yiw mutation (0 available); any Il1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil recruitment ( J:50775 )
• neutrophil influx into the peritoneal cavity after inoculation with a tumor cell line expressing FasL is about half that of controls

hematopoietic system
impaired neutrophil recruitment ( J:50775 )
• neutrophil influx into the peritoneal cavity after inoculation with a tumor cell line expressing FasL is about half that of controls




Genotype
MGI:4360503
cx4
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
Il1btm1Yiw mutation (0 available); any Il1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-1 alpha level ( J:47429 )
• mice do not produce IL-1alpha
decreased circulating interleukin-1 beta level ( J:47429 )
• mice do not produce IL-1beta
decreased susceptibility to type IV hypersensitivity reaction ( J:165513 )
• mice challenged with FITC and 2,4-dinitrofluorobenzene exhibit attenuated ear swelling compared with similarly treated wild-type mice
• mice challenged with methylated BSA exhibit impaired delayed-type hypersensitivity compared with similarly treated wild-type mice

homeostasis/metabolism
decreased circulating corticosterone level ( J:47429 )
• corticosterone levels 8 hours after injection of turpentine are elevated 2- to 3- fold in wild-type mice but not in mutant mice
• initial rises in corticosterone levels (within first 2 hours of injection) are similar to wild-type
decreased circulating interleukin-1 alpha level ( J:47429 )
• mice do not produce IL-1alpha
decreased circulating interleukin-1 beta level ( J:47429 )
• mice do not produce IL-1beta
impaired febrile response ( J:47429 )
• mice fail to develop a fever in response to turpentine administration while controls have a fever 1 to 4 days after injection




Genotype
MGI:5563673
cx5
Allelic
Composition		 Il1atm1Yiw/Il1atm1Yiw
Il1btm1Yiw/Il1btm1Yiw
Tg(KRT14-CASP1)1Miz/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation (0 available); any Il1a mutation (30 available)
Il1btm1Yiw mutation (0 available); any Il1b mutation (25 available)
Tg(KRT14-CASP1)1Miz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
dermatitis ( J:78602 )
• late onset of skin alterations which are similar to, but milder than, in single Tg(KRT14-CASP1)1Miz mutants

integument
dermatitis ( J:78602 )
• late onset of skin alterations which are similar to, but milder than, in single Tg(KRT14-CASP1)1Miz mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory