All Phenotypes Il1rn<tm1Yiw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il1rn^tm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:2157397

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1rn^tm1Yiw/Il1rn^tm1Yiw	B6.129-Il1rn^tm1Yiw	MGI:3687283
hm2	Il1rn^tm1Yiw/Il1rn^tm1Yiw	C.129-Il1rn^tm1Yiw	MGI:3830053
hm3	Il1rn^tm1Yiw/Il1rn^tm1Yiw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4360502
cx4	Il1r2^tm1Yiw/Il1r2^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw	B6.129-Il1r2^tm1Yiw Il1rn^tm1Yiw	MGI:7643411
cx5	Il17f^tm1Yiw/Il17f^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw	involves: 129 * BALB/c	MGI:3830054
cx6	Il17a^tm1Yiw/Il17a^tm1Yiw Il17f^tm1Yiw/Il17f^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw	involves: 129 * BALB/c	MGI:3830055
cx7	Il17a^tm1Yiw/Il17a^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw	involves: 129P2/OlaHsd * BALB/cA * C57BL/6J	MGI:3590198
cx8	Il1rn^tm1Yiw/Il1rn^tm1Yiw Il17a^tm1Yiw/Il17a⁺	involves: 129P2/OlaHsd * BALB/cA * C57BL/6J	MGI:3590199

Allelic Composition	Il1rn^tm1Yiw/Il1rn^tm1Yiw
Genetic Background	B6.129-Il1rn^tm1Yiw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rn^tm1Yiw mutation (0 available); any Il1rn mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular wound healing ( J:103068 )

• at 3 weeks after cuff-induced femoral artery injury, homozygotes exhibit significanlty enhanced neointimal formation, as shown by a 249% increase in mean intimal thickness and a 257% increase in neointima/media ratio, with no significant differences in medial thickness relative to wild-type mice

• in addition, homozygotes exhibit a 110% and 862% increase in the PCNA index of intima and adventitia, respectively

growth/size/body

decreased body weight ( J:103068 )

• at 12 weeks of age, homozygotes exhibit reduced body weight relative to wild-type littermates (25.20.7 g vs 31.11.1 g, respectively)

homeostasis/metabolism

abnormal vascular wound healing ( J:103068 )

• in addition, homozygotes exhibit a 110% and 862% increase in the PCNA index of intima and adventitia, respectively

Allelic Composition	Il1rn^tm1Yiw/Il1rn^tm1Yiw
Genetic Background	C.129-Il1rn^tm1Yiw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rn^tm1Yiw mutation (0 available); any Il1rn mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased interleukin-17 secretion ( J:143719 )

• there is increased secretion of both IL-17A and IL-17F by both lymph node cells and by cells isolated from synovial fluid

rheumatoid arthritis ( J:143719 )

• almost all mice develop autoimmune arthritis in the joints by 24 weeks of age

skeleton

rheumatoid arthritis ( J:143719 )

• almost all mice develop autoimmune arthritis in the joints by 24 weeks of age

Allelic Composition	Il1rn^tm1Yiw/Il1rn^tm1Yiw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rn^tm1Yiw mutation (0 available); any Il1rn mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:47429 )

• mice exhibit growth retardation after 6-8 weeks of age

• by 12 weeks of age, mean weight for males is 6 grams less than controls and 3 grams less for females

homeostasis/metabolism

abnormal body temperature homeostasis ( J:47429 )

• mice develop a fever in response to turpentine injection in a manner similar to wild-type mice but fail to return to normal body temperature for over a week

• wild-type mice return to a normal body-temperature within 5 days after injection

Allelic Composition	Il1r2^tm1Yiw/Il1r2^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw
Genetic Background	B6.129-Il1r2^tm1Yiw Il1rn^tm1Yiw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r2^tm1Yiw mutation (0 available); any Il1r2 mutation (32 available)
Il1rn^tm1Yiw mutation (0 available); any Il1rn mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased circulating tumor necrosis factor level ( J:274653 )

• mice treated with LPS show increased TNF production

• however, mice treated with Il-1beta do not show differences in IL-6 or TNF production from controls

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:274653 )

• mice treated with LPS show increased TNF production

• however, mice treated with Il-1beta do not show differences in IL-6 or TNF production from controls

Allelic Composition	Il17f^tm1Yiw/Il17f^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw
Genetic Background	involves: 129 * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17f^tm1Yiw mutation (0 available); any Il17f mutation (28 available)
Il1rn^tm1Yiw mutation (0 available); any Il1rn mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

rheumatoid arthritis ( J:143719 )

• mice develop autoimmune arthritis of the joints though with about 20% less incidence than in mice homozygote for just the Il1rn^tm1Yiw allele

skeleton

rheumatoid arthritis ( J:143719 )

• mice develop autoimmune arthritis of the joints though with about 20% less incidence than in mice homozygote for just the Il1rn^tm1Yiw allele

Allelic Composition	Il17a^tm1Yiw/Il17a^tm1Yiw Il17f^tm1Yiw/Il17f^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw
Genetic Background	involves: 129 * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17a^tm1Yiw mutation (0 available); any Il17a mutation (25 available)
Il17f^tm1Yiw mutation (0 available); any Il17f mutation (28 available)
Il1rn^tm1Yiw mutation (0 available); any Il1rn mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

rheumatoid arthritis ( J:143719 )

• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rn^tm1Yiw allele

• severity of disease of those affected is also significantly less than Il1rn^tm1Yiw homozygotes

skeleton

rheumatoid arthritis ( J:143719 )

• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rn^tm1Yiw allele

• severity of disease of those affected is also significantly less than Il1rn^tm1Yiw homozygotes

Allelic Composition	Il17a^tm1Yiw/Il17a^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw
Genetic Background	involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17a^tm1Yiw mutation (0 available); any Il17a mutation (25 available)
Il1rn^tm1Yiw mutation (0 available); any Il1rn mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to induced arthritis ( J:83408 )

• arthritis suppressed

skeleton

decreased susceptibility to induced arthritis ( J:83408 )

• arthritis suppressed

Allelic Composition	Il1rn^tm1Yiw/Il1rn^tm1Yiw Il17a^tm1Yiw/Il17a⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to induced arthritis ( J:83408 )

• reduced incidence of arthritis

• severity of arthritis not reduced

skeleton

decreased susceptibility to induced arthritis ( J:83408 )

• reduced incidence of arthritis

• severity of arthritis not reduced

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