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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il1rntm1Dih
targeted mutation 1, David Hirsh
MGI:2157398
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il1rntm1Dih/Il1rntm1Dih B6.129S-Il1rntm1Dih MGI:3573952
hm2
 		Il1rntm1Dih/Il1rntm1Dih involves: 129S/SvEv * C57BL/6J MGI:3583362
ht3
 		Il1rntm1Dih/Il1rn+ involves: 129S/SvEv * C57BL/6J MGI:3573733
cx4
 		Apoetm1Unc/Apoetm1Unc
Il1rntm1Dih/Il1rntm1Dih 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3789134


Genotype
MGI:3573952
hm1
Allelic
Composition		 Il1rntm1Dih/Il1rntm1Dih
Genetic
Background		 B6.129S-Il1rntm1Dih
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rntm1Dih mutation (1 available); any Il1rn mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:76336 )
• 3-fold decrease in non-HDL cholesterol when fed high fat diet containing cholate for 12 weeks




Genotype
MGI:3583362
hm2
Allelic
Composition		 Il1rntm1Dih/Il1rntm1Dih
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rntm1Dih mutation (1 available); any Il1rn mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:36387 )
• lower body weight apparent by 6 weeks of age

immune system
decreased circulating interleukin-1 level ( J:36387 )
• decreased serum levels of IL1 after endotoxin exposure
increased circulating interleukin-6 level ( J:61600 )
• increased basal serum IL6 levels
increased circulating serum amyloid protein level ( J:61600 )
• increased basal serum amyloid P levels
increased acute inflammation ( J:61600 , J:88605 )
• increased hepatic acute phase protein response to subcutaneous turpentine administration, increased mortality to turpentine abscess induction: 50% of mice died by day 5 (J:61600)
increased susceptibility to endotoxin shock ( J:36387 )
• more susceptible to lipopolysaccharide (LPS) endotoxin challenge
decreased susceptibility to bacterial infection ( J:36387 )
• less susceptible to experimental Listeria monocytogenes infection

reproductive system
reduced fertility ( J:61600 )
• decreased number of offspring

homeostasis/metabolism
decreased circulating cholesterol level ( J:76336 )
• 3-fold decrease in non-HDL cholesterol when fed high fat diet containing cholate for 12 weeks
decreased circulating interleukin-1 level ( J:36387 )
• decreased serum levels of IL1 after endotoxin exposure
increased circulating interleukin-6 level ( J:61600 )
• increased basal serum IL6 levels
increased circulating serum amyloid protein level ( J:61600 )
• increased basal serum amyloid P levels




Genotype
MGI:3573733
ht3
Allelic
Composition		 Il1rntm1Dih/Il1rn+
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rntm1Dih mutation (1 available); any Il1rn mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:36387 )
• heterozygotes exhibit an intermediate phenotype when compared to wild-type and homozygous mice

immune system
increased susceptibility to endotoxin shock ( J:36387 )
• more susceptible to lipopolysaccharide (LPS) endotoxin challenge
decreased susceptibility to bacterial infection ( J:36387 )
• less susceptible to experimental Listeria monocytogenes infection, heterozygotes display an intermediate phenotype




Genotype
MGI:3789134
cx4
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Il1rntm1Dih/Il1rntm1Dih
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Il1rntm1Dih mutation (1 available); any Il1rn mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:132570 )
• increased death rate on a high cholesterol diet

homeostasis/metabolism
decreased circulating cholesterol level ( J:132570 )
• significantly reduced plasma cholesterol levels relative to Apoetm1Unc homozygous controls on a normal diet

growth/size/body
decreased body weight ( J:132570 )
• relative to singly homozyous Apoetm1Unc

immune system
abnormal macrophage chemotaxis ( J:132570 )
• massive infiltration of macrophage in the aortic arch

cardiovascular system
cardiovascular system phenotype ( J:132570 )
N
• no intimal thickening occurs on a high cholesterol diet
abnormal aorta elastic tissue morphology ( J:132570 )
• elastic lamina in the media of the aortic root is destroyed
abnormal coronary artery morphology ( J:132570 )
• elastic lamina in the media of the coronary arteries is destroyed

cellular
abnormal macrophage chemotaxis ( J:132570 )
• massive infiltration of macrophage in the aortic arch

hematopoietic system
abnormal macrophage chemotaxis ( J:132570 )
• massive infiltration of macrophage in the aortic arch




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory