Phenotypes associated with this allele

• Allele Symbol: Twist1^Pde
• Allele Name: polydactyly EMS
• Allele ID: MGI:2157489
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Twist1^Pde/Twist1^Pde	involves: 129S1/Sv * C57BL/6J	MGI:2177042
ht2	Twist1^Pde/Twist1^+	involves: 129S1/Sv * C57BL/6J	MGI:2177044

Genotype
MGI:2177042

hm1

• Allelic Composition: Twist1^Pde/Twist1^Pde
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:69450 )

• animals resorbed by E11

nervous system

open neural tube ( J:69450 )

• failure of neural tube closure

exencephaly ( J:69450 )

embryo

open neural tube ( J:69450 )

• failure of neural tube closure

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Saethre-Chotzen syndrome		DOID:14768	OMIM:101400 OMIM:180750	J:69450

Genotype
MGI:2177044

ht2

• Allelic Composition: Twist1^Pde/Twist1⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

limbs/digits/tail

polydactyly ( J:69450 )

• extra preaxial toe found on hindlimbs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Saethre-Chotzen syndrome		DOID:14768	OMIM:101400 OMIM:180750	J:69450