Phenotypes associated with this allele

• Allele Symbol: Otx2^tm4(otd)Asim
• Allele Name: targeted mutation 4, Antonio Simeone
• Allele ID: MGI:2157779
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm4(otd)Asim/Otx2^tm4(otd)Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3796054

Genotype
MGI:3796054

hm1

• Allelic Composition: Otx2^tm4(otd)Asim/Otx2^tm4(otd)Asim
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal first pharyngeal arch morphology ( J:72726 )

• mandibular arch and derivatives are severely impaired or absent at 10.5 days post coitum (dpc)

craniofacial

abnormal maxillary prominence morphology ( J:72726 )

• maxillary process and derivatives are severely impaired or absent at 10.5 dpc

abnormal first pharyngeal arch morphology ( J:72726 )

• mandibular arch and derivatives are severely impaired or absent at 10.5 days post coitum (dpc)

growth/size/body

acephaly ( J:72726 )

• at 10.5 days post coitum (dpc), all embryos display a 'headless' phenotype

decreased body size ( J:72726 )

• one third of embryos at 10.5 dpc exhibit reduced body size