Phenotypes associated with this allele
Allelic
Composition |
Ptger3tm1Cof/Ptger3tm1Cof
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Genetic
Background |
either: (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) or (involves: 129P2/OlaHsd * 129S/SvEv) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger3tm1Cof mutation
(0 available);
any
Ptger3 mutation
(19 available)
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mortality/aging
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N |
• homozygotes are viable, fertile, and overtly normal with no developmental abnormalities in their major organ systems
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homeostasis/metabolism
renal/urinary system
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• in contrast to wild-type mice, homozygotes fail to exhibit a significant increase in basal urine osmolality after administration of PG synthesis inhibitor indomethacin
• nonetheless, homozygotes display normal regulation of urine volume and osmolality in response to various physiological stimuli
• in addition, homozygotes show normal changes in urine osmolality after treatment with vasopressin analog DDAVP
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger3tm1Cof mutation
(0 available);
any
Ptger3 mutation
(19 available)
|
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cardiovascular system
 N |
• at 5 months of age, male homozygotes show no significant differences in mean arterial blood pressure relative to wild-type controls
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• at 5 months of age, male homozygotes exhibit a 43% increase in baseline renal blood flow (RBF) relative to wild-type controls
• after local PGE2 (500 ng) injection into the renal artery, male homozygotes show a significantly greater maximum increase in RBF than wild-type controls, indicating increased renal vasodilation
• the maximum % increase in RBF is PGE2 dose-dependent, with 500 ng of PGE2 producing a greater increase in RBF than 25 ng of PGE2, unlike in wild-type controls
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• at 5 months of age, male homozygotes exhibit a 41% decrease in baseline renal vascular resistance relative to wild-type controls
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• after local PGE2 (500 ng) injection into the renal artery, male homozygotes show a significantly greater maximum increase in RBF than wild-type controls, indicating increased renal vasodilation
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muscle
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• after local PGE2 (500 ng) injection into the renal artery, male homozygotes show a significantly greater maximum increase in RBF than wild-type controls, indicating increased renal vasodilation
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renal/urinary system
|
N |
• at 5 months of age, male homozygotes show no significant differences in kidney weight relative to wild-type controls
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• at 5 months of age, male homozygotes exhibit a 43% increase in baseline renal blood flow (RBF) relative to wild-type controls
• after local PGE2 (500 ng) injection into the renal artery, male homozygotes show a significantly greater maximum increase in RBF than wild-type controls, indicating increased renal vasodilation
• the maximum % increase in RBF is PGE2 dose-dependent, with 500 ng of PGE2 producing a greater increase in RBF than 25 ng of PGE2, unlike in wild-type controls
|
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• at 5 months of age, male homozygotes exhibit a 41% decrease in baseline renal vascular resistance relative to wild-type controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger3tm1Cof mutation
(0 available);
any
Ptger3 mutation
(19 available)
|
|
|
immune system
|
N |
• at day 10, homozygotes show no significant differences in the course or severity of collagen antibody-induced rheumatoid arthritis relative to their respective genetic wild-type controls, based on paw swelling/redness and joint ankylosis
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger3tm1Cof mutation
(0 available);
any
Ptger3 mutation
(19 available)
|
|
|
Analysis Tools