Phenotypes associated with this allele

• Allele Symbol: Mafb^m1Gsb
• Allele Name: mutation 1, Gregory S Barsh
• Allele ID: MGI:2157803
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mafb^m1Gsb/Mafb^m1Gsb	B6.Cg-Mafb^m1Gsb	MGI:3778820

Genotype
MGI:3778820

hm1

• Allelic Composition: Mafb^m1Gsb/Mafb^m1Gsb
• Genetic Background: B6.Cg-Mafb^m1Gsb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal endocrine pancreas development ( J:132598 )

• there is a severe reduction in insulin and glucagon positive cells in the pancreas of E15.5

• as a percentage of total pancreatic epithelial area in E15.5 embryo, insulin positive area is reduced by 55% and glucagon area by 60%

• the reduction of insulin and glucagon cells is not accompanied by an increase in cells expressing somatostatin or ghrelin cells