Phenotypes associated with this allele

• Allele Symbol: Il1b^tm1Dch
• Allele Name: targeted mutation 1, David D Chaplin
• Allele ID: MGI:2157804
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1b^tm1Dch/Il1b^tm1Dch	B6.129S2-Il1b^tm1Dch	MGI:3851228
hm2	Il1b^tm1Dch/Il1b^tm1Dch	involves: 129S2/SvPas	MGI:3851219
hm3	Il1b^tm1Dch/Il1b^tm1Dch	involves: 129S2/SvPas * C57BL/6	MGI:3851222
cx4	Il18^tm1Aki/Il18^tm1Aki Il1b^tm1Dch/Il1b^tm1Dch	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3851238

Genotype
MGI:3851228

hm1

• Allelic Composition: Il1b^tm1Dch/Il1b^tm1Dch
• Genetic Background: B6.129S2-Il1b^tm1Dch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal tooth root resorption ( J:101998 )

• there is a significant increase in root resorption associated with orthodontic force on mutant's molar teeth compared to wild-type mice

Genotype
MGI:3851219

hm2

• Allelic Composition: Il1b^tm1Dch/Il1b^tm1Dch
• Genetic Background: involves: 129S2/SvPas

immune system

immune system phenotype ( J:189777 )

N • mice exposed to anthrax lethal toxin exhibit normal development of disease

decreased susceptibility to type IV hypersensitivity reaction ( J:33465 )

• mice show no footpad swelling after antigen challenge following sensitization with 0.1% TNCB, which generates maximal swelling in wild-type controls

• sensitization with 1% of TNCB is needed to generate the maximal response in mutant mice

• T cells isolated from draining lymph nodes fail to proliferate the TCNB to the same degree as T cells isolated from wild-type mice

decreased interleukin-1 beta secretion ( J:33465 )

• IL-1beta is not produced in these mice

increased susceptibility to bacterial infection ( J:112400 )

• mice succumb to 10⁸ CFU Salmonella infection more rapidly than controls

• there is an average 10-fold-higher bacterial loads in infected Peyer's patches, mesenteric lymph nodes, and spleens than in the infected organs of wild-type animals

Genotype
MGI:3851222

hm3

• Allelic Composition: Il1b^tm1Dch/Il1b^tm1Dch
• Genetic Background: involves: 129S2/SvPas * C57BL/6

homeostasis/metabolism

abnormal insulin-like growth factor I level ( J:71534 )

• cuprizone insult leads to increases in IGF-1 in the corpus callosum of wild-type mice that aids in the process of axon remyelination

• in contrast, mutant mice fail to produce IGF-1 in the corpus callosum after cuprizone insult

nervous system

abnormal oligodendrocyte morphology ( J:71534 )

• mice have defects in the regeneration of the mature oligodendrocyte population after a demyelinating insult

• after cuprizone insult, the number of oligodendrocytes present is significantly less than controls both 7 and 10 weeks after cuprizone withdrawal

• instead there is an increase oligodendrocyte precursors

abnormal myelination ( J:71534 )

• mice treated with cuprizone to cause demyelination have defects in remyelination

• only 45% of axons are remyelinated 4 weeks after cuprizone removal compared to 67.1% in controls

Genotype
MGI:3851238

cx4

• Allelic Composition: Il18^tm1Aki/Il18^tm1Aki; Il1b^tm1Dch/Il1b^tm1Dch
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

immune system

increased susceptibility to bacterial infection ( J:112400 )

• mice succumb more rapidly than controls to10⁸ CFU of Salmonella with a median survival time of 6 days compared to 8 days for controls

• there is an average 30-fold-higher bacterial loads in infected Peyer's patches, mesenteric lymph nodes, and spleens than in the infected organs of wild-type animals