Phenotypes associated with this allele

• Allele Symbol: H2-Aa^b-tm1Blt
• Allele Name: targeted mutation 1, Horst Bluethmann
• Allele ID: MGI:2157977
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-Aa^b-tm1Blt/H2-Aa^b-tm1Blt	C57BL/6-H2-Aa^b-tm1Blt	MGI:3623500

Genotype
MGI:3623500

hm1

• Allelic Composition: H2-Aa^b-tm1Blt/H2-Aa^b-tm1Blt
• Genetic Background: C57BL/6-H2-Aa^b-tm1Blt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged thymus ( J:16372 )

• slightly enlarged

thymus hyperplasia ( J:16372 )

• slightly increased cell number

abnormal T cell morphology ( J:16372 )

decreased CD4-positive, alpha-beta T cell number ( J:16372 )

• very few or no CD4+ T-cells in thymus

• about 4% CD4+ peripheral T-cells as opposed to 60% normally

increased CD8-positive, alpha-beta T cell number ( J:16372 )

• about 90% of lymph node T-cells are CD8+

abnormal MHC II cell surface expression on macrophages ( J:67924 )

• Class II expression is absent on bone-marrow derived macrophages

abnormal splenocyte physiology ( J:16372 )

• no splenocyte response to staphylococcal enterotoxin B

• response to T-cell independent antigens is normal

enlarged lymph nodes ( J:16372 )

• slightly enlarged

hematopoietic system

enlarged thymus ( J:16372 )

• slightly enlarged

thymus hyperplasia ( J:16372 )

• slightly increased cell number

abnormal T cell morphology ( J:16372 )

decreased CD4-positive, alpha-beta T cell number ( J:16372 )

• very few or no CD4+ T-cells in thymus

• about 4% CD4+ peripheral T-cells as opposed to 60% normally

increased CD8-positive, alpha-beta T cell number ( J:16372 )

• about 90% of lymph node T-cells are CD8+

abnormal MHC II cell surface expression on macrophages ( J:67924 )

• Class II expression is absent on bone-marrow derived macrophages

abnormal splenocyte physiology ( J:16372 )

• no splenocyte response to staphylococcal enterotoxin B

• response to T-cell independent antigens is normal

endocrine/exocrine glands

enlarged thymus ( J:16372 )

• slightly enlarged

thymus hyperplasia ( J:16372 )

• slightly increased cell number