All Phenotypes Smad1<tm1Rjle> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smad1^tm1Rjle
targeted mutation 1, Robert J Lechleider
MGI:2157982

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad1^tm1Rjle/Smad1^tm1Rjle	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:2448124
ht2	Smad1^tm1Rjle/Smad1⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:5827844
ht3	Smad1^tm1Rjle/Smad1⁺	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:3582566
cx4	Bmpr2^tm1Mmue/Bmpr2⁺ Smad1^tm1Rjle/Smad1⁺	involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6	MGI:5827848

Allelic Composition	Smad1^tm1Rjle/Smad1^tm1Rjle
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1^tm1Rjle mutation (0 available); any Smad1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:73279 )

• death at approximately E9.5

embryo

abnormal allantois morphology ( J:73279 )

• defective allantois formation

failure of chorioallantoic fusion ( J:73279 )

• allantois failed to fuse to chorion

Allelic Composition	Smad1^tm1Rjle/Smad1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1^tm1Rjle mutation (0 available); any Smad1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:224752 )

N	• mice do not exhibit increased right ventricular systolic pressure or right ventricular hypertrophy at 3 or 6 months of age

Allelic Composition	Smad1^tm1Rjle/Smad1⁺
Genetic Background	involves: 129S6/SvEvTac * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1^tm1Rjle mutation (0 available); any Smad1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:99098 )

• significant reduction in the number of heterozygous mutant mice at weaning

nervous system

abnormal neural tube morphology ( J:99098 )

• increased cellular proliferation in the dorsal region of the neural tube but not in the ventral region, resulting in neuroectodermal hypercellularity

abnormal midbrain morphology ( J:99098 )

• about 22% of E11.5 embryos exhibit reductions in the midbrain and hindbrain

abnormal hindbrain morphology ( J:99098 )

• about 22% of E11.5 embryos exhibit reductions in the midbrain and hindbrain

abnormal cranial nerve morphology ( J:99098 )

• have a curved cranial nerve likely to be a secondary effect caused by the abnormal architecture of the hindbrain

abnormal spinal nerve morphology ( J:99098 )

• exhibit a truncated spinal accessory nerve at E11.5

embryo

abnormal neural tube morphology ( J:99098 )

• increased cellular proliferation in the dorsal region of the neural tube but not in the ventral region, resulting in neuroectodermal hypercellularity

Allelic Composition	Bmpr2^tm1Mmue/Bmpr2⁺ Smad1^tm1Rjle/Smad1⁺
Genetic Background	involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2^tm1Mmue mutation (0 available); any Bmpr2 mutation (46 available)
Smad1^tm1Rjle mutation (0 available); any Smad1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

heart right ventricle hypertrophy ( J:224752 )

• right ventricular hypertrophy by 6 months of age

increased right ventricle systolic pressure ( J:224752 )

• by 6 months of age, mice develop more severe elevations in right ventricular systolic pressure than single Bmpr2 heterozygotes

growth/size/body

heart right ventricle hypertrophy ( J:224752 )

• right ventricular hypertrophy by 6 months of age

muscle

heart right ventricle hypertrophy ( J:224752 )

• right ventricular hypertrophy by 6 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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