Phenotypes associated with this allele

• Allele Symbol: Ccr2^tm1Ifc
• Allele Name: targeted mutation 1, Israel F Charo
• Allele ID: MGI:2158213
• Summary: 12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccr2^tm1Ifc/Ccr2^tm1Ifc	B6.129S4-Ccr2^tm1Ifc	MGI:4833681
hm2	Ccr2^tm1Ifc/Ccr2^tm1Ifc	B6.129S4-Ccr2^tm1Ifc/J	MGI:3580323
hm3	Ccr2^tm1Ifc/Ccr2^tm1Ifc	involves: 129S4/SvJae	MGI:3712665
hm4	Ccr2^tm1Ifc/Ccr2^tm1Ifc	involves: 129S4/SvJae * C57BL/6	MGI:4831132
hm5	Ccr2^tm1Ifc/Ccr2^tm1Ifc	involves: 129S4/SvJae * C57BL/6J	MGI:4831167
ht6	Ccr2^tm1Ifc/Ccr2^+	involves: 129S4/SvJae * C57BL/6	MGI:4831170
cx7	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc	B6.Cg-Apoe^tm1Unc Ccr2^tm1Ifc	MGI:4833679
cx8	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc	MGI:4833678
cx9	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^+	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4831159
cx10	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4831158
cx11	Ccr2^tm1Ifc/Ccr2^tm1Ifc Tg(APPSWE)2576Kha/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:4831169
cx12	Ccr2^tm1Ifc/Ccr2^+ Tg(APPSWE)2576Kha/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:4831171

Genotype
MGI:4833681

hm1

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: B6.129S4-Ccr2^tm1Ifc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:154558 )

N • mice exhibit normal experimental autoimmune uveitis

impaired leukocyte tethering or rolling ( J:154558 )

• monocyte rolling velocity is increased compared to in wild-type cells

decreased susceptibility to induced colitis ( J:161138 )

• DDS-treated mice fail to recruit macrophages and exhibit less colon shortening, weight loss, and clinical disease compared with similarly treated wild-type mice

digestive/alimentary system

decreased susceptibility to induced colitis ( J:161138 )

• DDS-treated mice fail to recruit macrophages and exhibit less colon shortening, weight loss, and clinical disease compared with similarly treated wild-type mice

cellular

impaired leukocyte tethering or rolling ( J:154558 )

• monocyte rolling velocity is increased compared to in wild-type cells

hematopoietic system

impaired leukocyte tethering or rolling ( J:154558 )

• monocyte rolling velocity is increased compared to in wild-type cells

Genotype
MGI:3580323

hm2

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: B6.129S4-Ccr2^tm1Ifc/J

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:106738 )

• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice

immune system

abnormal osteoclast differentiation ( J:149360 )

• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells

• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages

• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice

abnormal osteoclast cell number ( J:149360 )

• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice

decreased osteoclast cell number ( J:149360 )

• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice

abnormal leukocyte physiology ( J:122119 )

• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells

• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells

abnormal leukocyte migration ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

abnormal microglial cell physiology ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

abnormal osteoclast physiology ( J:149360 )

• resorptive capacity of osteoclasts is decreased compared to wild-type cells

decreased interferon-gamma secretion ( J:106738 )

• 10-fold in the central nervous system of mouse hepatitis virus (MHV-V5A13.1)-infected mice

decreased acute inflammation ( J:106738 )

• Th1 response to MHV-V5A13.1 infection is decreased compared to in wild-type mice

increased susceptibility to Coronaviridae infection ( J:106738 )

• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality and viral recovery from the brain and decreased infiltration of T cells and microglia/macrophage in the central nervous system (CNS), IFN-gamma levels in the CNS, and demyelination compared with similarly treated wild-type mice

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:106738 )

• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice

skeleton

abnormal osteoclast differentiation ( J:149360 )

• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells

• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages

• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice

abnormal osteoclast cell number ( J:149360 )

• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice

decreased osteoclast cell number ( J:149360 )

• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice

abnormal osteoclast physiology ( J:149360 )

• resorptive capacity of osteoclasts is decreased compared to wild-type cells

abnormal bone mineral density ( J:149360 )

• ovariectomized mice do not exhibit a change in bone marrow density unlike in similarly treated wild-type mice

abnormal trabecular bone morphology ( J:149360 )

increased trabecular bone volume ( J:149360 )

• mice exhibit a greater increase in trabecular bone volume fraction between 6 weeks and 10 weeks compared to in wild-type mice

abnormal bone trabecula morphology ( J:149360 )

• at 10 weeks, trabecular separation is decreased compared to in controls

increased trabecular bone thickness ( J:149360 )

decreased susceptibility to bone fracture ( J:149360 )

• mice exhibit an increase in force-to-failure values compared with wild-type mice

neoplasm

decreased tumor growth/size ( J:122119 )

• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells

nervous system

abnormal microglial cell physiology ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

hematopoietic system

abnormal osteoclast differentiation ( J:149360 )

• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells

• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages

• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice

abnormal osteoclast cell number ( J:149360 )

• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice

decreased osteoclast cell number ( J:149360 )

• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice

abnormal leukocyte physiology ( J:122119 )

• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells

• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells

abnormal leukocyte migration ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

abnormal microglial cell physiology ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

abnormal osteoclast physiology ( J:149360 )

• resorptive capacity of osteoclasts is decreased compared to wild-type cells

cellular

abnormal osteoclast differentiation ( J:149360 )

• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells

• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages

• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice

abnormal leukocyte migration ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

Genotype
MGI:3712665

hm3

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: involves: 129S4/SvJae

immune system

abnormal monocyte morphology ( J:121281 )

• 7/4^bri and 7/4^dim cells in the blood are decreased even after mice are fed a high fat diet

• intraperitoneal thioglycollate challenge leads to an increase in 7/4^bri cells

hematopoietic system

abnormal monocyte morphology ( J:121281 )

• 7/4^bri and 7/4^dim cells in the blood are decreased even after mice are fed a high fat diet

• intraperitoneal thioglycollate challenge leads to an increase in 7/4^bri cells

Genotype
MGI:4831132

hm4

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: involves: 129S4/SvJae * C57BL/6

immune system

abnormal macrophage chemotaxis ( J:44345 )

• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice

• however, the number of resident macrophage in mice is normal

impaired macrophage chemotaxis ( J:44345 , J:81363 , J:121703 )

• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)

• however, migration in response to MIP-1alpha is normal (J:44345)

• following injection of [3H]FC cat LDL into muscles (J:81363)

• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)

decreased T cell proliferation ( J:75838 )

• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice

decreased splenocyte proliferation ( J:75838 )

• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice

• however, proliferation in response to ConA or anti-CD3 antibodies is normal

abnormal microglial cell physiology ( J:121703 )

• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice

abnormal Langerhans cell physiology ( J:112594 )

• Langerhan cell repopulation after skin irradiation is impaired in these mice

abnormal immune serum protein physiology ( J:118971 )

decreased interferon-gamma secretion ( J:44345 , J:75838 )

• in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis (J:44345)

• in splenocytes treated with ConA (J:44345)

• in T cells and splenocytes from MOGp35-55 treated mice (J:75838)

increased interferon-gamma secretion ( J:61542 )

• in the livers of mice subjected to acute challenge with acetaminophen (APAP)

decreased interleukin-2 secretion ( J:44345 )

• in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis

decreased interleukin-6 secretion ( J:75838 )

• in splenocytes from MOGp35-55 treated mice

increased tumor necrosis factor secretion ( J:61542 )

• in the livers of mice subjected to acute challenge with acetaminophen (APAP)

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:75838 )

• MOGp35-55-treated mice fail to develop experimental autoimmune encephalomyelitis and exhibit no increase in chemokine production, reduced T cell and splenocyte proliferation, decreased IL6 production in splenocytes, and reduced IFN-gamma production in T cells and splenocytes compared with similarly treated wild-type mice

• however, monocyte recruitment in mice immunized with CFA beads is normal

decreased inflammatory response ( J:44345 )

• mice exposed to purified protein derivative (PPD) of Mycobacterium bovis produce smaller granulomas with fewer macrophages, no monocytosis, and decreased IFN-gamma and IL2 production compared with similarly treated wild-type mice

decreased susceptibility to type I hypersensitivity reaction ( J:118971 )

• mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response, increased lung MCP-1 levels, and no histamine release compared with similarly treated wild-type mice

• mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice

• however, eosinophil accumulation is normal

homeostasis/metabolism

increased circulating alanine transaminase level ( J:61542 )

• 120-fold above baseline in mice subjected to acute challenge with acetaminophen (APAP)

abnormal lipid homeostasis ( J:81363 )

• although serum levels of total and HDL cholesterol and phospholipids are slightly lower than in wild-type mice the difference was not statistically significant

abnormal cholesterol homeostasis ( J:81363 )

• cholesterol egress from muscles injected with [3H]FC cat LDL is slower than in similarly treated wild-type muscle due to a decrease in cholesteryl ester hydrolysis

increased physiological sensitivity to xenobiotic ( J:61542 )

• mice subjected to acute challenge with acetaminophen (APAP) exhibit liver necrosis/apoptosis, liver hemorrhage, and increased hepatic MCP-1, IFN-gamma, and TNF-alpha levels compared with similarly treated wild-type mice

• however, IL13 hepatic production in response to APAP is normal and immunoneutralization of IFN-gamma or TNF-alpha attenuates hepatotoxicity induced by APAP

liver/biliary system

liver hemorrhage ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

increased hepatocyte apoptosis ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

hepatic necrosis ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

cardiovascular system

liver hemorrhage ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

respiratory system

decreased airway responsiveness ( J:118971 )

• mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response compared with similarly treated wild-type mice

• mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice

hematopoietic system

abnormal macrophage chemotaxis ( J:44345 )

• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice

• however, the number of resident macrophage in mice is normal

impaired macrophage chemotaxis ( J:44345 , J:81363 , J:121703 )

• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)

• however, migration in response to MIP-1alpha is normal (J:44345)

• following injection of [3H]FC cat LDL into muscles (J:81363)

• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)

decreased T cell proliferation ( J:75838 )

• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice

decreased splenocyte proliferation ( J:75838 )

• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice

• however, proliferation in response to ConA or anti-CD3 antibodies is normal

decreased common myeloid progenitor cell number ( J:44345 )

• colony-forming unit granulocyte macrophage fail to form in response to mJE and hMCP-1 stimulation of bone marrow cells unlike similarly treated wild-type cells

• however, the number of progenitor cells in the marrow, spleen, and peripheral blood is normal

abnormal microglial cell physiology ( J:121703 )

• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice

nervous system

abnormal microglial cell physiology ( J:121703 )

• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice

cellular

increased hepatocyte apoptosis ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

abnormal macrophage chemotaxis ( J:44345 )

• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice

• however, the number of resident macrophage in mice is normal

impaired macrophage chemotaxis ( J:44345 , J:81363 , J:121703 )

• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)

• however, migration in response to MIP-1alpha is normal (J:44345)

• following injection of [3H]FC cat LDL into muscles (J:81363)

• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)

decreased T cell proliferation ( J:75838 )

• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice

decreased splenocyte proliferation ( J:75838 )

• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice

• however, proliferation in response to ConA or anti-CD3 antibodies is normal

Genotype
MGI:4831167

hm5

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

cardiovascular system

abnormal vascular wound healing ( J:110790 )

• cuff-induced neointimal hyperplasia is reduced compared to in similarly treated wild-type mice

homeostasis/metabolism

abnormal vascular wound healing ( J:110790 )

• cuff-induced neointimal hyperplasia is reduced compared to in similarly treated wild-type mice

Genotype
MGI:4831170

ht6

• Allelic Composition: Ccr2^tm1Ifc/Ccr2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

immune system

impaired macrophage chemotaxis ( J:121703 )

• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal

cellular

impaired macrophage chemotaxis ( J:121703 )

• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal

hematopoietic system

impaired macrophage chemotaxis ( J:121703 )

• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal

Genotype
MGI:4833679

cx7

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: B6.Cg-Apoe^tm1Unc Ccr2^tm1Ifc

cardiovascular system

decreased susceptibility to atherosclerosis ( J:153310 )

• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoe^tm1Unc homozygotes

hematopoietic system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

immune system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

Genotype
MGI:4833678

cx8

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ccr2^tm1Ifc/Ccr2^tm1Ifc; Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
• Genetic Background: B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc

cardiovascular system

decreased susceptibility to atherosclerosis ( J:153310 )

• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoe^tm1Unc homozygotes and Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

hematopoietic system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

immune system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

Genotype
MGI:4831159

cx9

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ccr2^tm1Ifc/Ccr2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

cardiovascular system

decreased susceptibility to atherosclerosis ( J:111471 )

• atherosclerotic lesions in mice fed a high fat diet for 5 weeks are smaller than in similarly treated Apoe^tm1Unc homozygotes

• however, no difference was observed at later time points

Genotype
MGI:4831158

cx10

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

cardiovascular system

decreased susceptibility to atherosclerosis ( J:111471 )

• in mice fed a high fat diet for 5, 9, and 13 weeks, atherosclerotic lesions are smaller than in similarly treated Apoe^tm1Unc homozygotes

• however, serum cholesterol levels are the same as in Apoe^tm1Unc homozygotes

immune system

impaired macrophage chemotaxis ( J:111471 )

• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoe^tm1Unc homozygotes

cellular

impaired macrophage chemotaxis ( J:111471 )

• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoe^tm1Unc homozygotes

hematopoietic system

impaired macrophage chemotaxis ( J:111471 )

• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoe^tm1Unc homozygotes

Genotype
MGI:4831169

cx11

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

mortality/aging

premature death ( J:121703 )

• by 130 days, 85% of mice are dead compared with 30% of mice expressing Tg(APPSWE)2576Kha, 1% of wild-type mice, and 3% of Ccr2^tm1Ifc homozygotes

nervous system

intracranial hemorrhage ( J:121703 )

abnormal microglial cell physiology ( J:121703 )

• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha

• however, microglial proliferation and responses to beta-amyloid are normal

amyloid beta deposits ( J:121703 )

• at P65 without classic plaques

immune system

abnormal microglial cell physiology ( J:121703 )

• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha

• however, microglial proliferation and responses to beta-amyloid are normal

cardiovascular system

intracranial hemorrhage ( J:121703 )

hematopoietic system

abnormal microglial cell physiology ( J:121703 )

• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha

• however, microglial proliferation and responses to beta-amyloid are normal

homeostasis/metabolism

amyloidosis ( J:121703 )

• at P65, accumulation of beta-amyloid 1-42 and 1-40 in the brain are 2.4-fold and 1.4-fold respectively compared to in mice expressing Tg(APPSWE)2576Kha

amyloid beta deposits ( J:121703 )

• at P65 without classic plaques

Genotype
MGI:4831171

cx12

• Allelic Composition: Ccr2^tm1Ifc/Ccr2⁺; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

mortality/aging

premature death ( J:121703 )

• by 130 days, 60% of mice are dead compared with 30% of mice expressing Tg(APPSWE)2576Kha, 1% of wild-type mice, and 3% of Ccr2^tm1Ifc homozygotes