All Phenotypes Atp4a<tm1Ges> MGI Mouse

abnormal gastric gland morphology ( J:63470 )

• large irregularly shaped cysts are sometimes seen near the apex of the adult gastric gland

abnormal stomach enteroendocrine cell morphology ( J:63470 )

• increase in number and size of enteroendocrine cell

abnormal gastric chief cell morphology ( J:63470 )

• chief cells appear to have fewer granules and rough endoplasmic reticulum

abnormal gastric parietal cell morphology ( J:63470 )

• parietal cells have dilated canaliculi, lack typical canalicular microvilli and tubulovesicles, and some have abnormal mitochondria and/or massive glycogen stores

dilated gastric gland ( J:63470 )

• occasionally 17 day old mutants exhibit dilated gastric glands while adults show serious disruption of the the architecture of the gastric gland

• thickness of the epithelial cell layer of the gastric glands is thinner, most likely due to the large dilations in the gastric gland lumen

gastric metaplasia ( J:63470 )

• adult stomachs contain cells with numerous distinct cilia located on the apical membrane that extend into the lumen of the gland, which are not seen in wild-type

achlorhydria ( J:63470 )

• homozygotes are achlorhydric (hydrochloric acid is absent in the gastric secretions of the stomach)

increased circulating gastrin level ( J:63470 )

• increased serum gastrin concentration