All Phenotypes Atp4b<tm1Ird> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp4b^tm1Ird/Atp4b^tm1Ird	either: (involves: 129S4/SvJae * BALB/cCrSlc) or (involves: 129S4/SvJae * C57BL/6)	MGI:3624963
cx2	Atp4b^tm1Ird/Atp4b^tm1Ird Gast^tm1Lcs/Gast^tm1Lcs	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc	MGI:3624965

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:74022 )

abnormal gastric gland morphology ( J:74022 , J:108678 )

• greater than normal total cell number (J:74022)

• gastric units two times as long as in controls at 35 days of age (J:108678)

abnormal gastric chief cell morphology ( J:74022 , J:108678 )

• lower than normal numbers of zymogenic cells (J:74022)

• zymogenic cells greatly reduced at 35 days of age (J:108678)

abnormal gastric parietal cell morphology ( J:74022 )

• parietal cells not recognizable at 15 days but present in normal numbers at 35 days

• parietal cells contain large vacuole-like structures

increased stomach mucosa thickness ( J:74022 )

• thickness normal at 15 days of age, with reduction of the base of the gastric unit but enlarged pit and isthmus regions

increased stomach pH ( J:74022 )

• luminal pH of stomach approximately 7.1 as opposed to 3.6 in controls

homeostasis/metabolism

increased circulating gastrin level ( J:74022 )

• elevated serum gastrin levels (hypergastrinemia)

endocrine/exocrine glands

abnormal gastric gland morphology ( J:74022 , J:108678 )

• greater than normal total cell number (J:74022)

• gastric units two times as long as in controls at 35 days of age (J:108678)

abnormal gastric chief cell morphology ( J:74022 , J:108678 )

• lower than normal numbers of zymogenic cells (J:74022)

• zymogenic cells greatly reduced at 35 days of age (J:108678)

abnormal gastric parietal cell morphology ( J:74022 )

• parietal cells not recognizable at 15 days but present in normal numbers at 35 days

• parietal cells contain large vacuole-like structures

Allelic Composition	Atp4b^tm1Ird/Atp4b^tm1Ird Gast^tm1Lcs/Gast^tm1Lcs
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp4b^tm1Ird mutation (2 available); any Atp4b mutation (31 available)
Gast^tm1Lcs mutation (1 available); any Gast mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:108678 )

• hypertrophy of the gastric mucosa is eliminated in the double homozygote

abnormal gastric gland morphology ( J:108678 )

• moderate increase in apoptotic cells and in immature cell numbers

abnormal gastric chief cell morphology ( J:108678 )

• near total absence of zymogenic cells

abnormal gastric parietal cell morphology ( J:108678 )

• sightly decreased number of parietal cells about half of which are vacuolated and half are normal