All Phenotypes Bcl2l1<tm1Dlo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bcl2l1^tm1Dlo
targeted mutation 1, Dennis Y Loh
MGI:2158303

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo	Not Specified	MGI:2176628
ht2	Bcl2l1^tm1Dlo/Bcl2l1⁺	B6.Cg-Bcl2l1^tm1Dlo	MGI:3847902
ht3	Bcl2l1^tm1Dlo/Bcl2l1^Plt20	involves: BALB/c * C57BL/6	MGI:3847905
cn4	Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu/0	B6.Cg-Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu	MGI:4840319
cx5	Bak1^tm1Thsn/Bak1^tm1Thsn Bcl2l1^tm1Dlo/Bcl2l1⁺	B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn	MGI:3847907
cx6	Bak1^tm1Thsn/Bak1⁺ Bcl2l1^tm1Dlo/Bcl2l1⁺	B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn	MGI:3847904
cx7	Bax^tm1Dlo/Bax^tm1Dlo Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo	involves: 129P2/OlaHsd	MGI:3609656
cx8	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Casp9^tm1Flv/?	involves: 129S1/Sv * C57BL/6	MGI:3609571
cx9	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Casp9^tm1Flv/Casp9^tm1Flv	involves: 129S1/Sv * C57BL/6	MGI:3609506

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:39573 )

• E12 dorsal root ganglia, brainstem and spinal cord have many more TUNEL positive cells than in wildtype mice

• E12 primary telencephalic cultures show increased apoptosis at 48 hours relative to wildtype or heterozyous cultures

cellular

increased apoptosis ( J:39573 )

increased neuron apoptosis ( J:39573 )

• E12 dorsal root ganglia, brainstem and spinal cord have many more TUNEL positive cells than in wildtype mice

• E12 primary telencephalic cultures show increased apoptosis at 48 hours relative to wildtype or heterozyous cultures

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1⁺
Genetic Background	B6.Cg-Bcl2l1^tm1Dlo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytopenia ( J:149205 )

• platelet counts are significantly lower than controls (860x10³/microliter vs 1100x10³/microliter)

abnormal platelet physiology ( J:149205 )

• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)

homeostasis/metabolism

abnormal platelet physiology ( J:149205 )

• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^Plt20
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytopenia ( J:149205 )

• platelet counts are 25% of normal

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu/0
Genetic Background	B6.Cg-Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(Aicda-cre)9Mbu mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:166069 )

N	• affinity maturation among NP-reactive B cells and germinal cell formation are normal

decreased IgG1 level ( J:166069 )

• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice

hematopoietic system

decreased IgG1 level ( J:166069 )

• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bcl2l1^tm1Dlo/Bcl2l1⁺
Genetic Background	B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytosis ( J:149205 )

• platelet cell numbers are about 50% higher than controls

abnormal platelet physiology ( J:149205 )

• platelet half-life is significantly increased by about 50% compared to controls

homeostasis/metabolism

abnormal platelet physiology ( J:149205 )

• platelet half-life is significantly increased by about 50% compared to controls

Allelic Composition	Bak1^tm1Thsn/Bak1⁺ Bcl2l1^tm1Dlo/Bcl2l1⁺
Genetic Background	B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal platelet morphology ( J:149205 )

• the low platelet numbers of Bcl2l1^tm1Dlo heterozygotes do not occur in these mice

Allelic Composition	Bax^tm1Dlo/Bax^tm1Dlo Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Dlo mutation (0 available); any Bax mutation (24 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:39573 )

• double heterozygous intercrosses yield no double homozygous liveborn

nervous system

decreased neuron apoptosis ( J:39573 )

• E12 brainstem and ventral spinal cord and E12 primary telencephalic cultures have fewer TUNEL positive cells than Bcl2l1^tm1Dlo homozygotes with one or two copies of wildtype Bax

cellular

decreased neuron apoptosis ( J:39573 )

• E12 brainstem and ventral spinal cord and E12 primary telencephalic cultures have fewer TUNEL positive cells than Bcl2l1^tm1Dlo homozygotes with one or two copies of wildtype Bax

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Casp9^tm1Flv/?
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)
Casp9^tm1Flv mutation (0 available); any Casp9 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:66953 )

• E12.5 brainstem and dorsal root ganglia, show increased numbers of apoptotic cells, and E12.5 primary telencephalic cultures show increased caspase 3 activation and cell death

cellular

increased apoptosis ( J:66953 )

• E12.5 liver show increased apoptotic cells

increased neuron apoptosis ( J:66953 )

• E12.5 brainstem and dorsal root ganglia, show increased numbers of apoptotic cells, and E12.5 primary telencephalic cultures show increased caspase 3 activation and cell death

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Casp9^tm1Flv/Casp9^tm1Flv
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:66953 )

• at E12.5 brainstem and dorsal root ganglia do not have the apoptosis found in Bcl2^tm1Dlo homozygotes, and E12.5 primary telencephalic cultures show decreased cell death and no caspase 3 activation relative to those of Bcl2l1^tm1Dlo homozygotes

increased apoptosis ( J:66953 )

• E12.5 liver has increased apoptosis similar to that seen in Bcl2l1^tm1Dlo homozygotes indicating no requirement for caspase 9 in liver apoptotis

nervous system

abnormal telencephalon development ( J:66953 )

• E12.5 histology shows thickened telencephalic vesicle, expanded ventricular zones, and cortical dysplasia

exencephaly ( J:66953 )

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