Analysis Tools
mortality/aging
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• about 20% survive for 5-7 weeks and the rest (about 10%) live longer than 10 weeks of age
|
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• about 70% die at 2-3 weeks, just before weaning
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growth/size/body
small ears
(
J:22391
)
|
• seen in most mutants
|
|
• develop polycystic kidney disease, although severity and age of onset varies
|
|
• at about 10 days after birth, some mutants are already smaller
|
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• at about 10 days after birth, some mutants are already smaller
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hearing/vestibular/ear
small ears
(
J:22391
)
|
• seen in most mutants
|
hematopoietic system
small thymus
(
J:22391
)
|
• small due to accelerated apoptosis of lymphocytes
|
|
• exhibit accelerated apoptosis of lymphocytes
• lymphocyte development initially appears normal, however lymphocytes from spleen or thymus lose the differentiated B220+/IgM+ B cell or CD4+/CD8+ T cell subpopulation, respectively
|
small spleen
(
J:22391
)
|
• small due to accelerated apoptosis of lymphocytes
|
|
• thymocytes show accelerated cell death in vitro
|
digestive/alimentary system
|
• retarded development and accelerated exfoliation of epithelial cells and very few mitotic progenitor cells in the small intestine
• the intestinal lumen shows clusters of apoptotic cells; apoptosis of epithelial cells is not restricted to the villus tip
|
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• the number of mitoses in crypts of small intestine varies considerably, but is smaller than in wild-type
|
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• villi of the small intestine are bizarre in shape
|
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• villi of the small intestine are shorter
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renal/urinary system
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• kidney architecture is very distored, suggesting that renal failure may be one cause of death
|
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• develop polycystic kidney disease, although severity and age of onset varies
|
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• only few recognizable glomeruli are seen
|
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• dilation of both distal and proximal convoluted tubules due to multiple cysts
|
|
• dilation of both distal and proximal convoluted tubules due to multiple cysts
|
pale kidney
(
J:22391
)
|
• kidneys are pale
|
pigmentation
|
• exhibit a lack of melanin in white hair
|
|
• hair hypopigmentation (hair turns white) in the second hair follicle cycle
• hypopigmentation begins at the chin and proceeds to the hip
|
endocrine/exocrine glands
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• the number of mitoses in crypts of small intestine varies considerably, but is smaller than in wild-type
|
small thymus
(
J:22391
)
|
• small due to accelerated apoptosis of lymphocytes
|
immune system
small thymus
(
J:22391
)
|
• small due to accelerated apoptosis of lymphocytes
|
|
• exhibit accelerated apoptosis of lymphocytes
• lymphocyte development initially appears normal, however lymphocytes from spleen or thymus lose the differentiated B220+/IgM+ B cell or CD4+/CD8+ T cell subpopulation, respectively
|
small spleen
(
J:22391
)
|
• small due to accelerated apoptosis of lymphocytes
|
|
• thymocytes show accelerated cell death in vitro
|
craniofacial
small ears
(
J:22391
)
|
• seen in most mutants
|
integument
|
• exhibit a lack of melanin in white hair
|
