All Phenotypes Bax<tm1Dlo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bax^tm1Dlo
targeted mutation 1, Dennis Y Loh
MGI:2158306

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bax^tm1Dlo/Bax^tm1Dlo	involves: 129P2/OlaHsd	MGI:3609600
cx2	Bax^tm1Dlo/Bax^tm1Dlo Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo	involves: 129P2/OlaHsd	MGI:3609656

Allelic Composition	Bax^tm1Dlo/Bax^tm1Dlo
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Dlo mutation (0 available); any Bax mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:66953 )

decreased neuron apoptosis ( J:39573 , J:66953 )

• E12 brainstem and ventral spinal cord have fewer TUNEL positive cells than normal while E12 primary telencephalic cultures show wildtype levels of apoptosis at 48 hours (J:39573)

• E12.5 primary telencephalic cultures show a small resistance to AraC induced neuronal cell death relative to wild-type (J:66953)

nervous system

decreased neuron apoptosis ( J:39573 , J:66953 )

• E12 brainstem and ventral spinal cord have fewer TUNEL positive cells than normal while E12 primary telencephalic cultures show wildtype levels of apoptosis at 48 hours (J:39573)

• E12.5 primary telencephalic cultures show a small resistance to AraC induced neuronal cell death relative to wild-type (J:66953)

Allelic Composition	Bax^tm1Dlo/Bax^tm1Dlo Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Dlo mutation (0 available); any Bax mutation (24 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:39573 )

• double heterozygous intercrosses yield no double homozygous liveborn

nervous system

decreased neuron apoptosis ( J:39573 )

• E12 brainstem and ventral spinal cord and E12 primary telencephalic cultures have fewer TUNEL positive cells than Bcl2l1^tm1Dlo homozygotes with one or two copies of wildtype Bax

cellular

decreased neuron apoptosis ( J:39573 )

• E12 brainstem and ventral spinal cord and E12 primary telencephalic cultures have fewer TUNEL positive cells than Bcl2l1^tm1Dlo homozygotes with one or two copies of wildtype Bax

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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