Phenotypes associated with this allele

• Allele Symbol: Igh-J^tm1Dhu
• Allele Name: targeted mutation 1, Dennis Huszar
• Allele ID: MGI:2158307
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm1Dhu/Igh^tm3Tim	involves: 129 * C57BL/6	MGI:3610405
cx2	Igh-J^tm1Dhu/Igh-J^tm1Dhu Wdr1^rede/Wdr1^rede	involves: 129S7/SvEvBrd * BALB/c * C57BL/6	MGI:3785509
cx3	Igh-J^tm1Dhu/Igh-J^tm1Dhu Il2^tm1Hor/Il2^tm1Hor	involves: 129/Sv * C57BL/6	MGI:3759413
cx4	Igh-J^tm1Dhu/Igh-J^+ Il2^tm1Hor/Il2^tm1Hor	involves: 129/Sv * C57BL/6	MGI:3759414
cx5	Igh-J^tm1Dhu/Igh^tm2Tim	involves: 129X1/SvJ * C57BL/6	MGI:3033132
cx6	Igh-J^tm1Dhu/Igh^tm1Tim	involves: 129X1/SvJ * C57BL/6	MGI:3033131
cx7	Igh-J^tm1Dhu/Igh-J^tm1(VDJ-17.2.25)Wabl Igk^tm1Dhu/Igk^tm1Dhu	Not Specified	MGI:3045805

Genotype
MGI:3610405

cx1

• Allelic Composition: Igh-J^tm1Dhu/Igh^tm3Tim
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:102308 )

• preferentially promoted development to marginal zone B cell

• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development

decreased B cell number ( J:102308 )

• B cell in mutants are reduced in the spleen, bone marrow and LNs

immune system

abnormal B cell differentiation ( J:102308 )

• preferentially promoted development to marginal zone B cell

• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development

decreased B cell number ( J:102308 )

• B cell in mutants are reduced in the spleen, bone marrow and LNs

Genotype
MGI:3785509

cx2

• Allelic Composition: Igh-J^tm1Dhu/Igh-J^tm1Dhu; Wdr1^rede/Wdr1^rede
• Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

immune system

abnormal immune system physiology ( J:134092 )

• the phenotype is similar to mice that are homozygote only for the Wdr1^rede allele indicating that the inflammatory lesions are not the result of B-cells activity

hematopoietic system

thrombocytopenia ( J:134092 )

• three week old mice have about 5-fold less platelets per liter of blood compared to wild-type littermates

Genotype
MGI:3759413

cx3

• Allelic Composition: Igh-J^tm1Dhu/Igh-J^tm1Dhu; Il2^tm1Hor/Il2^tm1Hor
• Genetic Background: involves: 129/Sv * C57BL/6

immune system

colitis ( J:29999 )

• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall

enlarged mesenteric lymph nodes ( J:29999 )

• are increased 3-10 fold in size as compared to control littermates

digestive/alimentary system

rectal hemorrhage ( J:29999 )

• is rarely observed

abnormal intestinal goblet cell morphology ( J:29999 )

• loss of mucin is observed in goblet cells

diarrhea ( J:29999 )

• occurs in mice 24 weeks of age

abnormal intestinal epithelium morphology ( J:29999 )

• crypt hyperplasia and unusual branching is observed

rectal prolapse ( J:29999 )

• occasional occurrence among mice whom live past 9 weeks of age

colitis ( J:29999 )

• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall

cardiovascular system

rectal hemorrhage ( J:29999 )

• is rarely observed

growth/size/body

cachexia ( J:29999 )

• weight loss resulting from intestinal inflammation is observed by 24 weeks

hematopoietic system

abnormal blood cell morphology/development ( J:29999 )

• : hemocrit levels are near normal (36% mean), suggesting B cells contribute to the anemia observed in mice lacking IL2 expression

behavior/neurological

hunched posture ( J:29999 )

• occurs in mice 24 weeks of age

cellular

abnormal intestinal goblet cell morphology ( J:29999 )

• loss of mucin is observed in goblet cells

Genotype
MGI:3759414

cx4

• Allelic Composition: Igh-J^tm1Dhu/Igh-J⁺; Il2^tm1Hor/Il2^tm1Hor
• Genetic Background: involves: 129/Sv * C57BL/6

immune system

colitis ( J:29999 )

• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall

enlarged mesenteric lymph nodes ( J:29999 )

• are increased 3-10 fold in size as compared to control littermates

digestive/alimentary system

rectal hemorrhage ( J:29999 )

• is rarely observed

abnormal intestinal goblet cell morphology ( J:29999 )

• loss of mucin is observed in goblet cells

diarrhea ( J:29999 )

• occurs in mice 24 weeks of age

abnormal intestinal epithelium morphology ( J:29999 )

• crypt hyperplasia and unusual branching is observed

rectal prolapse ( J:29999 )

• occasional occurrence among mice whom live past 9 weeks of age

colitis ( J:29999 )

• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall

cardiovascular system

rectal hemorrhage ( J:29999 )

• is rarely observed

growth/size/body

cachexia ( J:29999 )

• weight loss resulting from intestinal inflammation is observed by 24 weeks

hematopoietic system

anemia ( J:29999 )

• occurs in mice 24 weeks of age

behavior/neurological

hunched posture ( J:29999 )

• occurs in mice 24 weeks of age

cellular

abnormal intestinal goblet cell morphology ( J:29999 )

• loss of mucin is observed in goblet cells

Genotype
MGI:3033132

cx5

• Allelic Composition: Igh-J^tm1Dhu/Igh^tm2Tim
• Genetic Background: involves: 129X1/SvJ * C57BL/6

hematopoietic system

abnormal spleen morphology ( J:87624 )

• cell surface IgM levels are somewhat lower in B220+ and E4+ cells

• two cell populations, one in which surface IgD levels are normal, another in which they are substantially reduced

decreased marginal zone B cell number ( J:87624 )

• modestly reduced

immune system

abnormal spleen morphology ( J:87624 )

• cell surface IgM levels are somewhat lower in B220+ and E4+ cells

• two cell populations, one in which surface IgD levels are normal, another in which they are substantially reduced

decreased marginal zone B cell number ( J:87624 )

• modestly reduced

abnormal lymph node morphology ( J:87624 )

• cell surface IgD levels as in the spleen

Genotype
MGI:3033131

cx6

• Allelic Composition: Igh-J^tm1Dhu/Igh^tm1Tim
• Genetic Background: involves: 129X1/SvJ * C57BL/6

hematopoietic system

abnormal B cell morphology ( J:87624 )

• cell surface IgM levels are generally lower and particularly lower in E4+ cells

• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced

• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells

abnormal B cell differentiation ( J:88410 )

• B cell development was normal in bone marrow

• splenic B cells with a follicular phenotype and are E4+

• B cells do not express endogenous mu-chain

abnormal spleen morphology ( J:87624 )

abnormal spleen marginal zone morphology ( J:87624 )

• B cell area decreased in size

immune system

abnormal B cell morphology ( J:87624 )

• cell surface IgM levels are generally lower and particularly lower in E4+ cells

• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced

• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells

abnormal B cell differentiation ( J:88410 )

• B cell development was normal in bone marrow

• splenic B cells with a follicular phenotype and are E4+

• B cells do not express endogenous mu-chain

abnormal immune system organ morphology ( J:87624 )

abnormal spleen morphology ( J:87624 )

abnormal spleen marginal zone morphology ( J:87624 )

• B cell area decreased in size

Genotype
MGI:3045805

cx7

• Allelic Composition: Igh-J^tm1Dhu/Igh-J^{tm1(VDJ-17.2.25)Wabl}; Igk^tm1Dhu/Igk^tm1Dhu
• Genetic Background: Not Specified

hematopoietic system

abnormal B cell differentiation ( J:33628 )

• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2

abnormal immature B cell morphology ( J:89757 )

• 80% of bone marrow B cells have an immature phenotype

• rapid turnover

immune system

abnormal B cell differentiation ( J:33628 )

• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2

abnormal immature B cell morphology ( J:89757 )

• 80% of bone marrow B cells have an immature phenotype

• rapid turnover