All Phenotypes Bmpr1a<tm1Bhr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmpr1a^tm1Bhr
targeted mutation 1, Richard R Behringer
MGI:2158342

Summary

18 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmpr1a^tm1Bhr/Bmpr1a^tm1Bhr	129S7/SvEvBrd-Bmpr1a^tm1Bhr	MGI:2181287
hm2	Bmpr1a^tm1Bhr/Bmpr1a^tm1Bhr	B6.129S7-Bmpr1a^tm1Bhr	MGI:2181285
hm3	Bmpr1a^tm1Bhr/Bmpr1a^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:2181284
hm4	Bmpr1a^tm1Bhr/Bmpr1a^tm1Bhr	involves: 129S7/SvEvBrd * Swiss	MGI:2181286
ht5	Bmpr1a^tm1Bhr/Bmpr1a⁺	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:4830265
cn6	Bax^tm1Sjk/Bax^tm1Sjk Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6 * DBA/2 * ICR	MGI:3811313
cn7	Amhr2^tm3(cre)Bhr/Amhr2⁺ Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3042225
cn8	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:4941477
cn9	Bmpr1a^tm1Bhr/Bmpr1a^tm2Bhr Tg(Pou3f4-cre)32Cren/?	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:3046637
cn10	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Sftpc-cre)1Blh/0	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR	MGI:3811312
cn11	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(GATA6-cre)#Jbeb/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB	MGI:3663711
cn12	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Cga-cre)3Sac/0	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3819176
cn13	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Pou3f4-cre)32Cren/0	involves: 129S7/SvEvBrd * CD-1	MGI:2181350
cn14	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Six3-cre)69Frty/0	involves: 129S/SvEv	MGI:3574977
cn15	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b⁺ Tg(Six3-cre)69Frty/0	involves: 129S/SvEv	MGI:3574976
cn16	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Six3-cre)69Frty/0	Not Specified	MGI:3574975
cx17	Bmpr1a^tm1Bhr/Bmpr1a⁺ Col2a1^tm1.1Ksec/Col2a1^tm1.1Ksec	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:4830263
cx18	Bmpr1a^tm1Bhr/Bmpr1a⁺ Col2a1^tm1.1Ksec/Col2a1⁺	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:4830264

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm1Bhr
Genetic Background	129S7/SvEvBrd-Bmpr1a^tm1Bhr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:30426 )

• embryos normal at E5.5, absent after E9.5

• beginning to degenerate at E7.5

embryo

decreased embryo size ( J:30426 )

• embryos are half of normal size at E7.0

abnormal embryonic tissue morphology ( J:30426 )

• embryonic regions are approximately half of normal size at E7.0

increased embryonic epiblast cell apoptosis ( J:30426 )

• at E7.0, some of the epiblast cells in the thickened region show pyknotic nuclei, suggesting cell death

decreased embryonic epiblast cell proliferation ( J:30426 )

• proliferative ability of epiblast cells is already decreased by E6.5

thick embryonic epiblast ( J:30426 )

• at E7.0, the epiblast is thickened with multiple layers of cells, particularly in the distal portion

absent mesoderm ( J:30426 )

• no mesoderm at E7.0 and E7.5

failure of primitive streak formation ( J:30426 )

• no primitive streak at E7.0

abnormal embryonic-extraembryonic boundary morphology ( J:30426 )

• the boundary between the embryonic and extraembryonic regions is indistinct

abnormal visceral endoderm morphology ( J:30426 )

• thinner visceral endoderm at E7.0

growth/size/body

decreased embryo size ( J:30426 )

• embryos are half of normal size at E7.0

cellular

increased embryonic epiblast cell apoptosis ( J:30426 )

• at E7.0, some of the epiblast cells in the thickened region show pyknotic nuclei, suggesting cell death

decreased embryonic epiblast cell proliferation ( J:30426 )

• proliferative ability of epiblast cells is already decreased by E6.5

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm1Bhr
Genetic Background	B6.129S7-Bmpr1a^tm1Bhr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:30426 )

• embryos normal at E5.5, absent after E9.5

• beginning to degenerate at E7.5

embryo

decreased embryo size ( J:30426 )

• embryos are half of normal size at E7.0

abnormal embryonic tissue morphology ( J:30426 )

• embryonic regions are approximately half of normal size at E7.0

increased embryonic epiblast cell apoptosis ( J:30426 )

• at E7.0, some of the epiblast cells in the thickened region show pyknotic nuclei, suggesting cell death

decreased embryonic epiblast cell proliferation ( J:30426 )

• proliferative ability of epiblast cells is already decreased by E6.5

thick embryonic epiblast ( J:30426 )

• at E7.0, the epiblast is thickened with multiple layers of cells, particularly in the distal portion

absent mesoderm ( J:30426 )

• no mesoderm at E7.0 and E7.5

failure of primitive streak formation ( J:30426 )

• no primitive streak at E7.0

abnormal embryonic-extraembryonic boundary morphology ( J:30426 )

• the boundary between embryonic and extraembryonic regions is indistinct

abnormal visceral endoderm morphology ( J:30426 )

growth/size/body

decreased embryo size ( J:30426 )

• embryos are half of normal size at E7.0

cellular

increased embryonic epiblast cell apoptosis ( J:30426 )

• at E7.0, some of the epiblast cells in the thickened region show pyknotic nuclei, suggesting cell death

decreased embryonic epiblast cell proliferation ( J:30426 )

• proliferative ability of epiblast cells is already decreased by E6.5

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:30426 )

• embryos normal at E5.5, absent after E9.5

• beginning to degenerate at E7.5

embryo

decreased embryo size ( J:30426 )

• embryos are half of normal size at E7.0

abnormal embryonic tissue morphology ( J:30426 )

• embryonic regions are approximately half of normal size at E7.0

increased embryonic epiblast cell apoptosis ( J:30426 )

• at E7.0, some of the epiblast cells in the thickened region show pyknotic nuclei, suggesting cell death

decreased embryonic epiblast cell proliferation ( J:30426 )

• proliferative ability of epiblast cells is already decreased by E6.5

thick embryonic epiblast ( J:30426 )

• at E7.0, the epiblast is thickened with multiple layers of cells, particularly in the distal portion

absent mesoderm ( J:30426 )

• no mesoderm at E7.0 and E7.5

failure of primitive streak formation ( J:30426 )

• no primitive streak at E7.0

abnormal embryonic-extraembryonic boundary morphology ( J:30426 )

• the boundary between the embryonic and extraembryonic regions is indistinct

abnormal visceral endoderm morphology ( J:30426 )

• thinner visceral endoderm at E7.0

growth/size/body

decreased embryo size ( J:30426 )

• embryos are half of normal size at E7.0

cellular

increased embryonic epiblast cell apoptosis ( J:30426 )

• at E7.0, some of the epiblast cells in the thickened region show pyknotic nuclei, suggesting cell death

decreased embryonic epiblast cell proliferation ( J:30426 )

• proliferative ability of epiblast cells is already decreased by E6.5

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:30426 )

• embryos normal at E5.5, absent after E9.5

• beginning to degenerate at E7.5

embryo

decreased embryo size ( J:30426 )

• embryos are half of normal size at E7.0

abnormal embryonic tissue morphology ( J:30426 )

• embryonic regions are approximately half of normal size at E7.0

increased embryonic epiblast cell apoptosis ( J:30426 )

• at E7.0, some of the epiblast cells in the thickened region show pyknotic nuclei, suggesting cell death

decreased embryonic epiblast cell proliferation ( J:30426 )

• proliferative ability of epiblast cells is already decreased by E6.5

thick embryonic epiblast ( J:30426 )

• at E7.0, the epiblast is thickened with multiple layers of cells, particularly in the distal portion

absent mesoderm ( J:30426 )

• no mesoderm at E7.0 and E7.5

failure of primitive streak formation ( J:30426 )

• no primitive streak at E7.0

abnormal embryonic-extraembryonic boundary morphology ( J:30426 )

• the boundary between the embryonic and extraembryonic regions is indistinct

abnormal visceral endoderm morphology ( J:30426 )

• thinner visceral endoderm at E7.0

growth/size/body

decreased embryo size ( J:30426 )

• embryos are half of normal size at E7.0

cellular

increased embryonic epiblast cell apoptosis ( J:30426 )

• at E7.0, some of the epiblast cells in the thickened region show pyknotic nuclei, suggesting cell death

decreased embryonic epiblast cell proliferation ( J:30426 )

• proliferative ability of epiblast cells is already decreased by E6.5

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a⁺
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:163739 )

• neural tube deformities are seen in 1 of 11 mice

limbs/digits/tail

abnormal tail morphology ( J:163739 )

• tail deformities are seen in 1 of 11 mice

nervous system

abnormal neural tube morphology ( J:163739 )

• neural tube deformities are seen in 1 of 11 mice

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129 * C57BL/6 * DBA/2 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Bmpr1a^tm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung development ( J:106392 )

• while increased apoptosis of epithelial cells is rescued, mice exhibit abnormal branching morphogenesis

Allelic Composition	Amhr2^tm3(cre)Bhr/Amhr2⁺ Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Bmpr1a^tm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

male pseudohermaphroditism ( J:89999 )

• in addition to a normal male reproductive tract, XY mice developed uteri and oviducts

secondary sex reversal ( J:89999 )

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Bmpr1a^tm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:169133 )

N	• tamoxifen-treated mice exhibit normal sclerotome formation

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2Bhr Tg(Pou3f4-cre)32Cren/?
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Bmpr1a^tm2Bhr mutation (0 available); any Bmpr1a mutation (90 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:91054 )

• survived up to 17 days

integument

abnormal hair growth ( J:91054 )

alopecia ( J:91054 )

• lacked external hair in mid ventrum

abnormal hair shaft morphology ( J:91054 )

• shafts usually fail to form in follicles

abnormal hair follicle morphology ( J:91054 )

• wavy

abnormal hair follicle dermal papilla morphology ( J:91054 )

• misshapen and expanded dermal papillae

abnormal hair follicle orientation ( J:91054 )

• misangled

• not as deep into the dermis

small hair follicles ( J:91054 )

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:106392 )

• all mice die or are euthanized within 2 days of birth due to severe respiratory distress

respiratory system

respiratory system phenotype ( J:106392 )

N	• despite defects in distal portions of the lungs, proximal bronchi and bronchioles appear normal

abnormal lung morphology ( J:106392 )

• at E16.5, the distal regions of all four lobes are abnormal

• lungs are highly abnormal with large, fluid-filled (emphysematous) sacs

• however, lungs are normal at E12.5

abnormal lung epithelium morphology ( J:106392 )

• at E16.5, the number of more distal branches is reduced and branches are smaller than in wild-type mice

• epithelial cells in the periphery of the lung have a more rounded morphology than in wild-type mice

• epithelial cells cultured in a mesenchyme-free system fail to undergo secondary branching, develop fewer or no buds and exhibit a collapsed and folded morphology compared to wild-type cultures

decreased type II pneumocyte number ( J:106392 )

• fewer than normal as determined by surfactant C expression

abnormal respiratory system physiology ( J:106392 )

• despite defects in distal portions of the lungs, proximal bronchi and bronchioles appear normal

respiratory distress ( J:106392 )

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(GATA6-cre)#Jbeb/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal mitral valve cusp morphology ( J:111392 )

• 45% of 3-month old mutants show longer mitral septal leaflets

abnormal tricuspid valve morphology ( J:111392 )

• exhibit a premature disappearance of the myocardial layer in the tricuspid mural leaflet (present at E14.5 but absent at E15.5)

Ebstein's malformation of tricuspid valve ( J:111392 )

• the posterior annulus fibrosis is displaced downward into the right ventricular cavity in one of six mutants

abnormal tricuspid valve cusp morphology ( J:111392 )

• 36% of 3-month old mutants show longer tricuspid mural leaflets than control valves

decreased heart left ventricle muscle contractility ( J:111392 )

• 3-month old mutants show significantly decreased left ventricular (LV) ejection fraction and increased LV-end-systolic dimension and LV-end-diastolic dimension

mitral valve regurgitation ( J:111392 )

• show a 2-fold increase in left atrial pressure consistent with mitral insufficiency

abnormal impulse conducting system conduction ( J:111392 )

• isolated Langendorff perfused mutant hearts show a delta wave with abnormal surface ECG

• hearts with abnormal surface ECG show a base-to-apex activation pattern with evidence of a posterior paraseptal bypass tract

• the annulus fibrosus is disrupted resulting in ventricular preexcitation

absent PR interval ( J:111392 )

• 6 of 33 mutants, aged between 2 and 6 months, show absence of PR interval

muscle

decreased heart left ventricle muscle contractility ( J:111392 )

• 3-month old mutants show significantly decreased left ventricular (LV) ejection fraction and increased LV-end-systolic dimension and LV-end-diastolic dimension

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Ebstein anomaly	DOID:14289	OMIM:224700	J:111392
Wolff-Parkinson-White syndrome	DOID:384	OMIM:194200	J:111392

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Cga-cre)3Sac/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121318 )

• occurs at E12.5 likely due to heart defects

embryo

decreased embryo size ( J:121318 )

• embryos are smaller than wild-type littermates at prior to lethality

growth/size/body

decreased embryo size ( J:121318 )

• embryos are smaller than wild-type littermates at prior to lethality

endocrine/exocrine glands

abnormal pituitary gland development ( J:121318 )

abnormal Rathke's pouch development ( J:121318 )

• at E10.5 pouch is thin and underdeveloped compared to wild-type littermates

nervous system

abnormal pituitary gland development ( J:121318 )

abnormal Rathke's pouch development ( J:121318 )

• at E10.5 pouch is thin and underdeveloped compared to wild-type littermates

cardiovascular system

abnormal heart morphology ( J:121318 )

• embryos display heart defects

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Pou3f4-cre)32Cren/0
Genetic Background	involves: 129S7/SvEvBrd * CD-1

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:73526 )

ectopic digits ( J:73526 )

• ectopic distal phalanges are sometimes found

polydactyly ( J:73526 )

• although reduced digits is typical, polydactyly sometimes occurs

syndactyly ( J:73526 )

• polysyndactyly is common

abnormal hindlimb morphology ( J:73526 )

• if hindlimbs are present then they are highly malformed

• loss of ventral structures of hindlimbs

absent hindlimb ( J:73526 )

• in many but not all animals

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Six3-cre)69Frty/0
Genetic Background	involves: 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal retina pigment epithelium morphology ( J:96964 )

• at E12.5 the margin of the pigment epithelium is rough and a ventral discontinuity of the pigment is seen

vision/eye

increased retina apoptosis ( J:96964 )

• beginning at E11.25-E11.50 excess apoptosis is seen throughout the retina

abnormal eye development ( J:96964 )

• around E11.5 a drastic reduction in cell proliferation is seen in the retina

• Atoh7 expression is not initiated at E11.5 suggesting a failure to initiate retinal neurogenesis

abnormal retina morphology ( J:96964 )

• beginning at E11.25-E11.50 the retinal neuroectoderm is thinner

abnormal retina pigment epithelium morphology ( J:96964 )

• at E12.5 the margin of the pigment epithelium is rough and a ventral discontinuity of the pigment is seen

anophthalmia ( J:96964 )

• eyes are small at E12.5 and absent at birth

cellular

increased retina apoptosis ( J:96964 )

• beginning at E11.25-E11.50 excess apoptosis is seen throughout the retina

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b⁺ Tg(Six3-cre)69Frty/0
Genetic Background	involves: 129S/SvEv

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:96964 )

• many dorsal retinal ganglion cell axons form ectopic termination zones

• eye size and retinal layer morphology are normal

nervous system

abnormal retina ganglion cell morphology ( J:96964 )

• many dorsal retinal ganglion cell axons form ectopic termination zones

• eye size and retinal layer morphology are normal

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Six3-cre)69Frty/0
Genetic Background	Not Specified

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:96964 )

N	• no overt eye abnormalities are seen, the retinal layers and retinotectal projections are normal

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a⁺ Col2a1^tm1.1Ksec/Col2a1^tm1.1Ksec
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Col2a1^tm1.1Ksec mutation (0 available); any Col2a1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:163739 )

• underrepresented at birth and in the embryonic stages

craniofacial

midface hypoplasia ( J:163739 )

• midface hypoplasia is seen in 1 of 1 mice

vision/eye

cyclopia ( J:163739 )

• seen in 1 of 1 mice

growth/size/body

midface hypoplasia ( J:163739 )

• midface hypoplasia is seen in 1 of 1 mice

microcephaly ( J:163739 )

• seen in 1 of 1 mice

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a⁺ Col2a1^tm1.1Ksec/Col2a1⁺
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:163739 )

• neural tube deformities are seen in 2 of 15 mice

limbs/digits/tail

abnormal tail morphology ( J:163739 )

• tail deformities are seen in 2 of 15 mice

vision/eye

enophthalmos ( J:163739 )

• seen in 1 of 15 mice

nervous system

abnormal neural tube morphology ( J:163739 )

• neural tube deformities are seen in 2 of 15 mice

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