Phenotypes associated with this allele

• Allele Symbol: Bmpr1a^tm2Bhr
• Allele Name: targeted mutation 1, Richard R Behringer
• Allele ID: MGI:2158343
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr Tg(KRT14-cre/ERT2)1Ipc/?	involves: 129S7/SvEvBrd * C57BL/6	MGI:3046636
cn2	Bmpr1a^tm1Bhr/Bmpr1a^tm2Bhr Tg(Pou3f4-cre)32Cren/?	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:3046637
cn3	Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr Tg(KRT14-cre)40Smr/?	involves: 129S7/SvEvBrd * C57BL/6J * SJL/J	MGI:3046633
cn4	Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr Tg(KRT14-cre)43Smr/?	involves: 129S7/SvEvBrd * C57BL/6J * SJL/J	MGI:3046634
cn5	Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr Tg(KRT14-cre)52Smr/0	involves: 129S7/SvEvBrd * C57BL/6J * SJL/J	MGI:3046635

Genotype
MGI:3046636

cn1

• Allelic Composition: Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr; Tg(KRT14-cre/ERT2)1Ipc/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91054 )

• survived at least 6 months when not treated with tamoxifen which causes the mice to become sickly

neoplasm

preneoplasia ( J:91054 )

• benign proliferations derived from hair follicles and follicular cysts

• tamoxifen treatment accelerated cyst formation

integument

abnormal hair growth ( J:91054 )

sparse hair ( J:91054 )

• sparse hair becoming more severe with age

abnormal nail morphology ( J:91054 )

• abnormal growths under the nails

abnormal hair follicle morphology ( J:91054 )

• maintained in proliferative state

Genotype
MGI:3046637

cn2

• Allelic Composition: Bmpr1a^tm1Bhr/Bmpr1a^tm2Bhr; Tg(Pou3f4-cre)32Cren/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

mortality/aging

postnatal lethality, complete penetrance ( J:91054 )

• survived up to 17 days

integument

abnormal hair growth ( J:91054 )

alopecia ( J:91054 )

• lacked external hair in mid ventrum

abnormal hair shaft morphology ( J:91054 )

• shafts usually fail to form in follicles

abnormal hair follicle morphology ( J:91054 )

• wavy

abnormal hair follicle dermal papilla morphology ( J:91054 )

• misshapen and expanded dermal papillae

abnormal hair follicle orientation ( J:91054 )

• misangled

• not as deep into the dermis

small hair follicles ( J:91054 )

Genotype
MGI:3046633

cn3

• Allelic Composition: Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr; Tg(KRT14-cre)40Smr/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

skeleton

abnormal tooth morphology ( J:91054 )

absent teeth ( J:91054 )

• complete absence of incisors and molars

mortality/aging

premature death ( J:91054 )

• survive several months

craniofacial

abnormal tooth morphology ( J:91054 )

absent teeth ( J:91054 )

• complete absence of incisors and molars

growth/size/body

abnormal tooth morphology ( J:91054 )

absent teeth ( J:91054 )

• complete absence of incisors and molars

decreased body size ( J:91054 )

integument

abnormal hair growth ( J:91054 )

alopecia ( J:91054 )

• decreased external hair

abnormal hair shaft morphology ( J:91054 )

• shafts usually fail to form in follicles

abnormal nail morphology ( J:91054 )

• abnormal growths under the nails

abnormal hair follicle morphology ( J:91054 )

• wavy

abnormal hair follicle dermal papilla morphology ( J:91054 )

• misshapen and expanded dermal papillae

abnormal hair follicle orientation ( J:91054 )

• misangled

• not as deep into the dermis

small hair follicles ( J:91054 )

abnormal hair follicle regression ( J:91054 )

• failed to undergo regression as late as day 34

Genotype
MGI:3046634

cn4

• Allelic Composition: Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr; Tg(KRT14-cre)43Smr/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

skeleton

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars

mortality/aging

neonatal lethality, complete penetrance ( J:91054 )

• died within 24 hours

behavior/neurological

abnormal suckling behavior ( J:91054 )

• difficulty suckling

craniofacial

abnormal mouth morphology ( J:91054 )

• oral abnormalities resulting from defective tooth development

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars

limbs/digits/tail

absent hindlimb ( J:91054 )

vision/eye

eyelids open at birth ( J:91054 )

integument

increased hair follicle number ( J:91054 )

• dorsal follicle density significantly increased

growth/size/body

abnormal mouth morphology ( J:91054 )

• oral abnormalities resulting from defective tooth development

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars

Genotype
MGI:3046635

cn5

• Allelic Composition: Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr; Tg(KRT14-cre)52Smr/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

skeleton

absent teeth ( J:91054 )

mortality/aging

postnatal lethality, complete penetrance ( J:91054 )

• die within first 4 days

behavior/neurological

abnormal suckling behavior ( J:91054 )

• difficulty suckling

craniofacial

abnormal mouth morphology ( J:91054 )

• oral abnormalities resulting from defective tooth development

absent teeth ( J:91054 )

growth/size/body

abnormal mouth morphology ( J:91054 )

• oral abnormalities resulting from defective tooth development

absent teeth ( J:91054 )

decreased body size ( J:91054 )

• severely runted

integument

abnormal hair growth ( J:91054 )

alopecia ( J:91054 )

• lacked external hair

abnormal hair shaft morphology ( J:91054 )

• shafts usually fail to form in follicles

abnormal hair follicle morphology ( J:91054 )

• wavy

abnormal hair follicle dermal papilla morphology ( J:91054 )

• misshapen and expanded dermal papillae

abnormal hair follicle orientation ( J:91054 )

• misangled

• not as deep into the dermis

small hair follicles ( J:91054 )