All Phenotypes Ccr2<tm1Mae> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccr2^tm1Mae/Ccr2^tm1Mae	B6.129P2-Ccr2^tm1Mae	MGI:3841005
hm2	Ccr2^tm1Mae/Ccr2^tm1Mae	involves: 129P2/OlaHsd	MGI:4355951
hm3	Ccr2^tm1Mae/Ccr2^tm1Mae	involves: 129P2/OlaHsd * BALB/c	MGI:4834178
hm4	Ccr2^tm1Mae/Ccr2^tm1Mae	involves: 129P2/OlaHsd * C57BL/6J	MGI:3654650
cx5	Ccl2^tm1Rol/Ccl2^tm1Rol Ccr2^tm1Mae/Ccr2^tm1Mae	B6.129-Ccr2^tm1Mae Ccl2^tm1Rol	MGI:4418654
cx6	Ccr2^tm1Mae/Ccr2^tm1Mae Msmp^em1Jzx/Msmp^em1Jzx	involves: 129P2/OlaHsd * C57BL/6	MGI:6771353
cx7	A^y/a Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Mae/Ccr2^tm1Mae	involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl	MGI:5297861

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

bronchiolitis ( J:162707 )

• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice

vision/eye

retina photoreceptor degeneration ( J:147328 )

• at 16 months

abnormal retina pigment epithelium morphology ( J:147328 )

• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice

• at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice

retina outer nuclear layer degeneration ( J:147328 )

• at 16 months

increased susceptibility to age-related retinal degeneration ( J:147328 )

• at 16 months, mice exhibit progressive outer retinal degeneration and confluent areas of visible atrophy unlike in wild-type mice

• at 18 months, mice exhibit geographic atrophy unlike in wild-type mice

retina deposits ( J:147328 )

• after 9 months of age, mice exhibit subretinal deposits similar to drusen that increase with age unlike in wild-type mice

abnormal optic choroid morphology ( J:147328 )

• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice

abnormal choriocapillaris morphology ( J:147328 )

• at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice

choroidal neovascularization ( J:147328 )

• at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice

• after 18 months, 3 of 13 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice

• between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice

abnormal Bruch membrane morphology ( J:147328 )

• the Bruch membrane is thickened compared to in wild-type mice after 9 months of age

• at 20 months, the outer Bruch membrane is breached by choriocapillary processes unlike in wild-type mice

behavior/neurological

alcohol aversion ( J:102583 )

• mice exhibit decreased preference for ethanol water compared with wild-type mice

• female mice exhibit a lesser ethanol preference compared with Ccl2^tm1Rol Ccr2^tm1Mae double homozygotes

decreased alcohol consumption ( J:102583 )

abnormal conditioned taste aversion behavior ( J:102583 )

• mice develop a stronger ethanol-induced conditioned taste aversion compared with similarly treated wild-type mice

increased fluid intake ( J:102583 )

• mice exhibit increased drinking of a quinine solution compared with wild-type mice

increased alcohol consumption ( J:102583 )

• mice exhibit increased drinking of an ethanol solution compared with wild-type mice and Ccl2^tm1Rol Ccr2^tm1Mae double homozygotes

immune system

decreased macrophage cell number ( J:147328 )

• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice

increased IgG level ( J:147328 )

• at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice

• IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice

bronchiolitis ( J:162707 )

• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice

increased susceptibility to Coronaviridae infection ( J:162707 )

• mice show increased susceptibility to infection with a recombinant mouse-adapted SARS-CoV, rMA15 , developing more severe and prolonged disease compared to wild-type mice, showing more prominent airway epithelial cell apoptosis, severe denuding bronchiolitis and perivenular/periarterial cuffing

cardiovascular system

abnormal choriocapillaris morphology ( J:147328 )

• at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice

choroidal neovascularization ( J:147328 )

• at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice

• after 18 months, 3 of 13 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice

• between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice

nervous system

retina photoreceptor degeneration ( J:147328 )

• at 16 months

pigmentation

abnormal retina pigment epithelium morphology ( J:147328 )

• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice

• at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice

lipofuscinosis ( J:147328 )

• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice

hematopoietic system

decreased macrophage cell number ( J:147328 )

• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice

increased IgG level ( J:147328 )

• at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice

• IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
age related macular degeneration	DOID:10871	OMIM:PS603075	J:147328
Coronavirus infectious disease	DOID:0080599		J:162707

Allelic Composition	Ccr2^tm1Mae/Ccr2^tm1Mae
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2^tm1Mae mutation (3 available); any Ccr2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:311042 )

• in mice exposed to CCL4

decreased susceptibility to injury ( J:311042 )

• mice exposed to CCL4 exhibit attenuated livery injury and fibrosis with reduced alanine transferase (ALT) levels compared with wild-type mice

immune system

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

impaired macrophage chemotaxis ( J:151874 , J:191510 )

• very few macrophages are recruited in response to induced peritonitis (J:151874)

• recruitment of macrophages in mice homozygous for Ccl2^tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)

abnormal chemokine secretion ( J:151874 )

• there is over a 2-fold increase in Ccl2 and Ccl7 secretion by activated macrophages compared to controls

cellular

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

impaired macrophage chemotaxis ( J:151874 , J:191510 )

• very few macrophages are recruited in response to induced peritonitis (J:151874)

• recruitment of macrophages in mice homozygous for Ccl2^tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)

hematopoietic system

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

impaired macrophage chemotaxis ( J:151874 , J:191510 )

• very few macrophages are recruited in response to induced peritonitis (J:151874)

• recruitment of macrophages in mice homozygous for Ccl2^tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)

Allelic Composition	Ccr2^tm1Mae/Ccr2^tm1Mae
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2^tm1Mae mutation (3 available); any Ccr2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased neutrophil cell number ( J:162714 )

• following kidney ischemia and reperfusion

abnormal leukocyte physiology ( J:162714 )

• following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice

impaired macrophage chemotaxis ( J:162714 )

• following kidney ischemia and reperfusion

homeostasis/metabolism

decreased circulating creatinine level ( J:162714 )

• following kidney ischemia and reperfusion, plasma creatinine levels fail to increase as in similarly treated wild-type mice

decreased susceptibility to kidney reperfusion injury ( J:162714 )

• following kidney ischemia and reperfusion, mice fail to exhibit an increase in plasma creatinine levels and exhibit reduced renal tubular cell necrosis and neutrophil and macrophage infiltration compared with similarly treated wild-type mice

renal/urinary system

decreased susceptibility to kidney reperfusion injury ( J:162714 )

hematopoietic system

decreased neutrophil cell number ( J:162714 )

• following kidney ischemia and reperfusion

abnormal leukocyte physiology ( J:162714 )

• following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice

impaired macrophage chemotaxis ( J:162714 )

• following kidney ischemia and reperfusion

cellular

impaired macrophage chemotaxis ( J:162714 )

• following kidney ischemia and reperfusion

Allelic Composition	Ccr2^tm1Mae/Ccr2^tm1Mae
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2^tm1Mae mutation (3 available); any Ccr2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:110814 )

• mice lose ~15% body weight by day 7 of treatment, comparable to wild-type

immune system

increased susceptibility to induced colitis ( J:110814 )

• mice develop DSS-mediated colitis at a delayed and lower severity compared to wild-type treated mice after 7 days of treatment

increased B cell number ( J:110814 )

• mice display an increase in B cell number in the lamina propria from 27 to 43% compared to wild-type and Ccr5-deficient mice which show a transient decrease in number at day 3 and then rebound to original values by day 7 of treatment

decreased CD4-positive, alpha-beta T cell number ( J:110814 )

• a decrease in number is observed at day 3 of DSS treatment

increased CD8-positive, alpha-beta T cell number ( J:110814 )

• an increase in number is observed at day 3

abnormal cytokine secretion ( J:110814 )

• mice expression one fifth the wild-type level of Ifng in the intestinal mucosa after day 3 and 7, while Il-4 is increased 3-fold and a 9-fold increase in Il-10 over wild-type and 4-fold greater than Ccr5-deficient mice after DSS-treatment

decreased inflammatory response ( J:110814 )

• mice show significantly fewer intraabdominal adhesions than wild-type; the colons are less erythamatous and show less ulceration; average percentage of ulcerated tissue is less than wild-type at day 3 of treatment

digestive/alimentary system

diarrhea ( J:110814 )

• by day 7 of a course of dextran sodium sulfate (DSS) in drinking water, null mice develop stool diarrhea and hemoccult-positive, often bloody stool similar to wild-type; development of diarrhea and bloody stools is delayed compared to wild-type with diminished hemoccult scores on day 4 and diminished diarrhea on days 1, 3, and 4

increased susceptibility to induced colitis ( J:110814 )

• mice develop DSS-mediated colitis at a delayed and lower severity compared to wild-type treated mice after 7 days of treatment

hematopoietic system

increased B cell number ( J:110814 )

decreased CD4-positive, alpha-beta T cell number ( J:110814 )

• a decrease in number is observed at day 3 of DSS treatment

increased CD8-positive, alpha-beta T cell number ( J:110814 )

• an increase in number is observed at day 3

Allelic Composition	Ccl2^tm1Rol/Ccl2^tm1Rol Ccr2^tm1Mae/Ccr2^tm1Mae
Genetic Background	B6.129-Ccr2^tm1Mae Ccl2^tm1Rol

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2^tm1Rol mutation (2 available); any Ccl2 mutation (25 available)
Ccr2^tm1Mae mutation (3 available); any Ccr2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

alcohol aversion ( J:102583 )

• compared to in Ccl2^tm1Rol homozygotes

alcohol preference ( J:102583 )

• compared to in Ccr2^tm1Mae homozygotes

decreased alcohol consumption ( J:102583 )

• compared to in Ccl2^tm1Rol or Ccr2^tm1Mae homozygotes

Allelic Composition	Ccr2^tm1Mae/Ccr2^tm1Mae Msmp^em1Jzx/Msmp^em1Jzx
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2^tm1Mae mutation (3 available); any Ccr2 mutation (43 available)
Msmp^em1Jzx mutation (0 available); any Msmp mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:311042 )

• in mice exposed to CCL4 despite adenoviral expression of PSMP

decreased susceptibility to injury ( J:311042 )

• despite adenoviral expression of PSMP, mice exposed to CCL4 exhibit attenuated livery injury and fibrosis with reduced alanine transferase (ALT) levels compared with wild-type mice

Allelic Composition	A^y/a Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Mae/Ccr2^tm1Mae
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
A^y mutation (12 available); any a mutation (463 available)
Ccr2^tm1Mae mutation (3 available); any Ccr2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:177084 )

N	• mutants are protected against the metabolic syndrome, atherosclerosis, and diabetic nephropathy that develops in A^y/a Apoe^tm1Unc double mutants

increased circulating leptin level ( J:177084 )

increased circulating cholesterol level ( J:177084 )

decreased circulating adiponectin level ( J:177084 )

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