All Phenotypes Mecp2<tm1Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mecp2^tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:2158353

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mecp2^tm1Jae/Y Chat^tm2(cre)Lowl/Chat⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:6098756
cn2	Mapt^{tm1(Setdb1)Akba}/Mapt⁺ Mecp2^tm1Jae/Y Tg(Nes-cre)1Atp/0	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5299159
cn3	Mapt^{tm1(Setdb1)Akba}/Mapt^{tm1(Setdb1)Akba} Mecp2^tm1Jae/Y Tg(Nes-cre)1Atp/0	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5299160
cn4	Mecp2^tm1Jae/Y Tg(Camk2a-cre)93Kln/0	involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J	MGI:3624685
cn5	Mecp2^tm1Jae/Y Tg(Nes-cre)1Atp/0	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:3624680
cn6	Mecp2^tm1Jae/Mecp2⁺ Tg(Nes-cre)1Atp/0	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:3624684
cn7	Mecp2^tm1Jae/Y Tg(Myh6-cre)2182Mds/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * FVB/N	MGI:6098758
cn8	Mecp2^tm1Jae/Y Tg(Camk2a-Setdb1)1Akba/0 Tg(Nes-cre)1Atp/0	involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL	MGI:5299161
ot9	Mecp2^tm1Jae/Y	involves: 129S4/SvJae * C57BL/6	MGI:5299162

Allelic Composition	Mecp2^tm1Jae/Y Chat^tm2(cre)Lowl/Chat⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:241788 )

• 67% of mice die early with a median life span of 16 months

cardiovascular system

abnormal heartbeat ( J:241788 )

• irregular heart rhythm and sudden drops in heart rate

increased heart rate variability ( J:241788 )

• increase in heart rate variability during both the light and dark cycles

decreased heart rate ( J:241788 )

• heart rate during the dark cycle is decreased but is not different during the light cycle

ventricular tachycardia ( J:241788 )

• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia

ventricular premature beat ( J:241788 )

• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia

prolonged QT interval ( J:241788 )

increased response of heart to induced stress ( J:241788 )

• mice are highly susceptible to inducible arrhythmias

homeostasis/metabolism

increased response of heart to induced stress ( J:241788 )

• mice are highly susceptible to inducible arrhythmias

decreased body temperature ( J:241788 )

• mice exhibit decreased temperature during the dark cycle but not the light cycle

behavior/neurological

behavior/neurological phenotype ( J:241788 )

N	• mice show no differences in activity during the light or dark cycle

respiratory system

respiratory system phenotype ( J:241788 )

N	• mice do not exhibit increased basal apneas or abnormal hypoxic response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:241788

Allelic Composition	Mapt^{tm1(Setdb1)Akba}/Mapt⁺ Mecp2^tm1Jae/Y Tg(Nes-cre)1Atp/0
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^{tm1(Setdb1)Akba} mutation (0 available); any Mapt mutation (430 available)
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Nes-cre)1Atp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:178512 )

• most mice die between 8 weeks and 24 weeks of age

behavior/neurological

impaired coordination ( J:178512 )

Allelic Composition	Mapt^{tm1(Setdb1)Akba}/Mapt^{tm1(Setdb1)Akba} Mecp2^tm1Jae/Y Tg(Nes-cre)1Atp/0
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:178512 )

• most mice die between 8 weeks and 24 weeks of age

behavior/neurological

impaired coordination ( J:178512 )

Allelic Composition	Mecp2^tm1Jae/Y Tg(Camk2a-cre)93Kln/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Camk2a-cre)93Kln mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:67909 )

• mutants appear healthy for up to 3 months when they begin to exhibit an ataxic gait

decreased locomotor activity ( J:67909 )

• mutants appear healthy for up to 3 months when they begin to show reduced nocturnal activity

growth/size/body

increased susceptibility to age related obesity ( J:67909 )

• 7 of 11 become overweight and obese at 10 weeks of age or older

• mutants appear healthy for up to 3 months when they begin to gain weight

nervous system

decreased brain weight ( J:67909 )

abnormal hippocampus CA2 region morphology ( J:67909 )

• neurons in the CA2 region are 15-25% smaller than in controls at 7.5 months of age

abnormal neuron morphology ( J:67909 )

• exhibit smaller neuronal bodies in the cortex and hippocampus but not in the cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:67909

Allelic Composition	Mecp2^tm1Jae/Y Tg(Nes-cre)1Atp/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Nes-cre)1Atp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:67909 )

• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death

behavior/neurological

abnormal behavior ( J:67909 )

• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age

abnormal pilomotor reflex ( J:67909 )

tremors ( J:67909 )

• exhibit body trembling at 5 weeks of age

• at late stages of disease, mutants tremble when handled

decreased locomotor activity ( J:67909 )

• seen at late stages of disease

nervous system

decreased brain size ( J:67909 )

decreased brain weight ( J:67909 )

abnormal hippocampus CA2 region morphology ( J:67909 )

• neurons in the CA2 region are 15-25% smaller than in controls at 8 weeks of age

abnormal neuron morphology ( J:67909 )

• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed

growth/size/body

cachexia ( J:67909 )

• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease

obese ( J:67909 )

• 6 of 18 become overweight and obese at 40-60 days of age

respiratory system

abnormal respiration ( J:67909 )

• occasionally show heavy breathing at 5 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:67909

Allelic Composition	Mecp2^tm1Jae/Mecp2⁺ Tg(Nes-cre)1Atp/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Nes-cre)1Atp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:67909 )

• females appear normal for the first 4 months but show ataxic gait at later ages

decreased locomotor activity ( J:67909 )

• females appear normal for the first 4 months but show hypoactivity at later ages

growth/size/body

increased susceptibility to age related obesity ( J:67909 )

• females appear normal for the first 4 months but gain weight at later ages

Allelic Composition	Mecp2^tm1Jae/Y Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:241788 )

N	• mice show no differences in activity in either the light or dark phases

cardiovascular system

cardiovascular system phenotype ( J:241788 )

N	• mice do not exhibit an increase in sinus pauses, premature ventricular contractions, atrioventricular block, or nonsustained ventricular tachycardia, and do not show QT prolongation or increased susceptibility to induced arrhythmias

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:241788 )

N	• mice show no changes in temperature in either the light or dark phases

Allelic Composition	Mecp2^tm1Jae/Y Tg(Camk2a-Setdb1)1Akba/0 Tg(Nes-cre)1Atp/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Camk2a-Setdb1)1Akba mutation (0 available)
Tg(Nes-cre)1Atp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:178512 )

• mice die between 8 and 40 weeks of age

behavior/neurological

impaired coordination ( J:178512 )

decreased locomotor activity ( J:178512 )

• worse than in Mecp2^tm1Jae/Y mice

growth/size/body

decreased body weight ( J:178512 )

Allelic Composition	Mecp2^tm1Jae/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:178512 )

decreased locomotor activity ( J:178512 )

growth/size/body

decreased body weight ( J:178512 )

mortality/aging

premature death ( J:178512 )

• mice die between 8 and 40 weeks of age

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