Analysis Tools|
Allele Symbol Allele Name Allele ID |
St8sia1tm1Rlp targeted mutation 1, Richard L Proia MGI:2158360 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice are viable and fertile, have normal growth, and exhibit no gross behavior abnormalities
|
| N |
• mice exhibit normal myelination
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 50% of mice die by 13 weeks
• 92% of mice die by 36 weeks
• 9 of 10 mice die during the tonic phase of an audiogenic seizure due to respiratory arrest
|
 |
• sperm maturation is defective
|
| N |
• mice exhibit no neuronal cell loss or demyelination
|
|
• some mice exhibit spontaneous and/or handling-induced seizures unlike wild-type mice
|
|
• beginning as a brief wild-running phase and followed by a clonic-tonic seizure
|
|
• 9 of 10 mice die during the tonic phase of a seizure due to respiratory arrest
|
|
• some mice exhibit spontaneous and/or handling-induced seizures unlike wild-type mice
|
|
• beginning as a brief wild-running phase and followed by a clonic-tonic seizure
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/19/2024 MGI 6.24 |
|
|
|
||
