Phenotypes associated with this allele

• Allele Symbol: Traf4^tm2Lind
• Allele Name: targeted mutation 2, Tullia Lindsten
• Allele ID: MGI:2158362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traf4^tm2Lind/Traf4^tm2Lind	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3776752

Genotype
MGI:3776752

hm1

• Allelic Composition: Traf4^tm2Lind/Traf4^tm2Lind
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:74252 )

• at 7 weeks of age, males have a lower (-10%) body weight than wild-type males, while females show a 5% decrease

respiratory system

lung inflammation ( J:74252 )

• many mutants exhibiting inspiratory stridor show lung inflammation upon examination, with areas of leukocyte infiltration; no asymptomatic animals displayed inflammation

abnormal tracheal cartilage morphology ( J:74252 )

• width of rings and U-shaped form of rings remain intact, but a ventrally pointed appearance is evident

trachea stenosis ( J:74252 )

• external diameter is reduced by an average of 18%, resulting in a 32% decrease in cross-sectional area

• mice show tracheal stenosis

stridor ( J:74252 )

• some mutants (20%) at any one time display inspiratory stridor, evidenced by a high-pitched wheezing noise; this could be severe at times, but mice could be asymptomatic within weeks

skeleton

abnormal tracheal cartilage morphology ( J:74252 )

• width of rings and U-shaped form of rings remain intact, but a ventrally pointed appearance is evident

immune system

immune system phenotype ( J:74252 )

N • T cells from mutant animals respond as well as wild-type cells to aerosolized challenge; attenuated response in vivo to challenge is due to tracheal stenosis resulting in reduced antigen reaching the lungs

lung inflammation ( J:74252 )

• many mutants exhibiting inspiratory stridor show lung inflammation upon examination, with areas of leukocyte infiltration; no asymptomatic animals displayed inflammation