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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atp2b2Tmy
tommy
MGI:2158375
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atp2b2Tmy/Atp2b2Tmy involves: BALB/c * C3H/HeH MGI:4879111
ht2
Atp2b2Tmy/Atp2b2+ involves: BALB/c * C3H/HeH MGI:4879108


Genotype
MGI:4879111
hm1
Allelic
Composition
Atp2b2Tmy/Atp2b2Tmy
Genetic
Background
involves: BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2Tmy mutation (2 available); any Atp2b2 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• visibly smaller than litter mates in 22% of homozygotes showing a more severe phenotype

hearing/vestibular/ear
• increased ABR thresholds indicate a profound hearing impairment at 18 days in 22% of homozygotes showing a more severe phenotype
• deaf from birth in 22% of homozygotes showing a more severe phenotype

behavior/neurological
• severe ataxia in 22% of homozygotes showing a more severe phenotype
• hesitant, wobbly gait in 22% of homozygotes showing a more severe phenotype
• frequent hyperextension of rear limbs in 22% of homozygotes showing a more severe phenotype




Genotype
MGI:4879108
ht2
Allelic
Composition
Atp2b2Tmy/Atp2b2+
Genetic
Background
involves: BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2Tmy mutation (2 available); any Atp2b2 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• middle ear and inner ear gross morphology is normal
• significant difference in response when compared to controls with clicks or at burst frequencies of 14 kHz or higher
• hearing is normal at 4 weeks as determined by flick preyer response to a transient 20kHz pure tone
• profound deafness first observed at around 12 weeks of age and fully penetrant after 30 weeks





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory