All Phenotypes Mecom<Jbo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mecom^Jbo/Mecom^Jbo	C3N.C-Mecom^Jbo	MGI:3689579
ht2	Mecom^Jbo/Mecom⁺	C3N.C-Mecom^Jbo	MGI:3689583
ht3	Mecom^Jbo/Mecom⁺	involves: BALB/c	MGI:6102908
ht4	Mecom^Jbo/Mecom^tm1Mmor	involves: 129S2/SvPas * BALB/c * C3H/HeN * CF-1	MGI:3689584

Allelic Composition	Mecom^Jbo/Mecom^Jbo
Genetic Background	C3N.C-Mecom^Jbo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecom^Jbo mutation (2 available); any Mecom mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Polydactyly in Mecom^Jbo/Evi1⁺ and Mecom^Jbo/Mecom^Jbo mice

mortality/aging

perinatal lethality, incomplete penetrance ( J:113445 )

• when carried by a wild-type surrogate mother, many homozygotes which were normal in appearance and body size proceeded to die between E18.5 and birth

• some homozygote embryos may die at E10.5

embryonic lethality during organogenesis, incomplete penetrance ( J:113445 )

• some homozygote embryos may die at E10.5

limbs/digits/tail

brachydactyly ( J:113445 )

• the anterior digit of forelimb at E18.5 is often reduced in size

polydactyly ( J:113445 )

• extra digits are seen on both forelimbs at E18.5

abnormal limb development ( J:113445 )

• 17% of homozygote mice had small hid limbs at E10.5 when carried by a wild-type surrogate mother

cardiovascular system

distended pericardium ( J:113445 )

• 17% of homozygote mice had a large pericardial sac at E10.5 when carried by a wild-type surrogate mother

nervous system

abnormal forebrain morphology ( J:113445 )

• 17% of homozygote mice had a malformed forebrain at E10.5 when carried by a wild-type surrogate mother

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Polydactyly in Mecom^Jbo/Evi1⁺ and Mecom^Jbo/Mecom^Jbo mice

hearing/vestibular/ear

abnormal tympanic membrane morphology ( J:113445 )

• fibrous thickening and perforation of the tympanic membrane associated with otitis media were common among adult heterozygotes over 29 days after birth

tympanic membrane perforation ( J:113445 )

• common among adult heterozygotes over 29 days after birth

deafness ( J:90559 , J:113445 )

• late onset (J:90559)

• demonstrated a hearing loss at approximately 40 days after birth (J:113445)

increased susceptibility to otitis media ( J:113445 )

• the middle ear cavity of adult mutant mice was filled with exudate, indicative of otitis media

• otitis media was resent in 100% of heterozygotes at weaning and continue to develop bilateral chronic suppurative otitis media

• no gross morphological defects of the inner ear and ossicular chain or ossification of the temporal bone and tympanic ring were found among mutant mice

• in conventionally housed mice, 100% of the mutant mice had acute otitis media by 13 days after birth compared to about 33% in wild-type

• in pathogen free facility condition, otitis media in mutant mice are relatively milder or absent at early time points and is not associated with rhinitis; however otitis media developed in 100% of mutant mice in this condition by 54 days after birth

reproductive system

increased miscarriage rate ( J:113445 )

• female heterozygotes undergo repeated spontaneous abortion

limbs/digits/tail

polydactyly ( J:90559 , J:113445 )

• extra digit (J:90559)

• an extra digit is seen on one forelimb at E18.5 (J:113445)

immune system

immune system phenotype ( J:113445 )

N	• no significant histological lesions in intestine, liver, pancreas, kidney, heart, thymus, and spleen • no significances in the antibody responses, levels of immature, mature cell forms, and total circulating blood neutrophils

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

increased susceptibility to otitis media ( J:113445 )

• the middle ear cavity of adult mutant mice was filled with exudate, indicative of otitis media

• otitis media was resent in 100% of heterozygotes at weaning and continue to develop bilateral chronic suppurative otitis media

• no gross morphological defects of the inner ear and ossicular chain or ossification of the temporal bone and tympanic ring were found among mutant mice

• in conventionally housed mice, 100% of the mutant mice had acute otitis media by 13 days after birth compared to about 33% in wild-type

respiratory system inflammation ( J:113445 )

• in conventionally housed mice, otitis media found in 100% of heterozygotes mice are part of a more generalized respiratory tract inflammation

• no significant intralesional bacteria or viral inclusions

respiratory system

respiratory system inflammation ( J:113445 )

• in conventionally housed mice, otitis media found in 100% of heterozygotes mice are part of a more generalized respiratory tract inflammation

• no significant intralesional bacteria or viral inclusions

hematopoietic system

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

cellular

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

craniofacial

abnormal craniofacial morphology ( J:90559 )

• craniofacial defect

growth/size/body

decreased body weight ( J:90559 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:113445

Allelic Composition	Mecom^Jbo/Mecom⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecom^Jbo mutation (2 available); any Mecom mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:250208 )

N	• mice exhibit normal inner ear morphology

middle ear effusion ( J:250208 )

middle ear polyps ( J:250208 )

• edematous polyps projecting into the middle ear cavity

impaired hearing ( J:250208 )

• poor performance to the click-box

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

behavior/neurological

abnormal pinna reflex ( J:250208 )

• poor performance to the click-box

homeostasis/metabolism

middle ear effusion ( J:250208 )

immune system

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:250208

Allelic Composition	Mecom^Jbo/Mecom^tm1Mmor
Genetic Background	involves: 129S2/SvPas * BALB/c * C3H/HeN * CF-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecom^Jbo mutation (2 available); any Mecom mutation (81 available)
Mecom^tm1Mmor mutation (2 available); any Mecom mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:113445 )

• a complementation cross between Evi1^Jbo/ Evi1⁺ and Evi1^tm1Mmor/ Evi1⁺ produced no progeny among 81 live births which co-inherited the Evi1^Jbo and Evi1^tm1Mmor mutations, indicating perinatal lethality

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24