All Phenotypes Mecom<Jbo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mecom^Jbo/Mecom^Jbo	C3N.C-Mecom^Jbo	MGI:3689579
ht2	Mecom^Jbo/Mecom⁺	C3N.C-Mecom^Jbo	MGI:3689583
ht3	Mecom^Jbo/Mecom⁺	involves: BALB/c	MGI:6102908
ht4	Mecom^Jbo/Mecom^tm1Mmor	involves: 129S2/SvPas * BALB/c * C3H/HeN * CF-1	MGI:3689584

Allelic Composition	Mecom^Jbo/Mecom^Jbo
Genetic Background	C3N.C-Mecom^Jbo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecom^Jbo mutation (2 available); any Mecom mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Polydactyly in Mecom^Jbo/Evi1⁺ and Mecom^Jbo/Mecom^Jbo mice

mortality/aging

perinatal lethality, incomplete penetrance ( J:113445 )

• when carried by a wild-type surrogate mother, many homozygotes which were normal in appearance and body size proceeded to die between E18.5 and birth

• some homozygote embryos may die at E10.5

embryonic lethality during organogenesis, incomplete penetrance ( J:113445 )

• some homozygote embryos may die at E10.5

limbs/digits/tail

brachydactyly ( J:113445 )

• the anterior digit of forelimb at E18.5 is often reduced in size

polydactyly ( J:113445 )

• extra digits are seen on both forelimbs at E18.5

abnormal limb development ( J:113445 )

• 17% of homozygote mice had small hid limbs at E10.5 when carried by a wild-type surrogate mother

cardiovascular system

distended pericardium ( J:113445 )

• 17% of homozygote mice had a large pericardial sac at E10.5 when carried by a wild-type surrogate mother

nervous system

abnormal forebrain morphology ( J:113445 )

• 17% of homozygote mice had a malformed forebrain at E10.5 when carried by a wild-type surrogate mother

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Polydactyly in Mecom^Jbo/Evi1⁺ and Mecom^Jbo/Mecom^Jbo mice

hearing/vestibular/ear

abnormal tympanic membrane morphology ( J:113445 )

• fibrous thickening and perforation of the tympanic membrane associated with otitis media were common among adult heterozygotes over 29 days after birth

tympanic membrane perforation ( J:113445 )

• common among adult heterozygotes over 29 days after birth

deafness ( J:90559 , J:113445 )

• late onset (J:90559)

• demonstrated a hearing loss at approximately 40 days after birth (J:113445)

increased susceptibility to otitis media ( J:113445 )

• the middle ear cavity of adult mutant mice was filled with exudate, indicative of otitis media

• otitis media was resent in 100% of heterozygotes at weaning and continue to develop bilateral chronic suppurative otitis media

• no gross morphological defects of the inner ear and ossicular chain or ossification of the temporal bone and tympanic ring were found among mutant mice

• in conventionally housed mice, 100% of the mutant mice had acute otitis media by 13 days after birth compared to about 33% in wild-type

• in pathogen free facility condition, otitis media in mutant mice are relatively milder or absent at early time points and is not associated with rhinitis; however otitis media developed in 100% of mutant mice in this condition by 54 days after birth

reproductive system

increased miscarriage rate ( J:113445 )

• female heterozygotes undergo repeated spontaneous abortion

limbs/digits/tail

polydactyly ( J:90559 , J:113445 )

• extra digit (J:90559)

• an extra digit is seen on one forelimb at E18.5 (J:113445)

immune system

immune system phenotype ( J:113445 )

N	• no significant histological lesions in intestine, liver, pancreas, kidney, heart, thymus, and spleen • no significances in the antibody responses, levels of immature, mature cell forms, and total circulating blood neutrophils

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

increased susceptibility to otitis media ( J:113445 )

• the middle ear cavity of adult mutant mice was filled with exudate, indicative of otitis media

• otitis media was resent in 100% of heterozygotes at weaning and continue to develop bilateral chronic suppurative otitis media

• no gross morphological defects of the inner ear and ossicular chain or ossification of the temporal bone and tympanic ring were found among mutant mice

• in conventionally housed mice, 100% of the mutant mice had acute otitis media by 13 days after birth compared to about 33% in wild-type

respiratory system inflammation ( J:113445 )

• in conventionally housed mice, otitis media found in 100% of heterozygotes mice are part of a more generalized respiratory tract inflammation

• no significant intralesional bacteria or viral inclusions

respiratory system

respiratory system inflammation ( J:113445 )

• in conventionally housed mice, otitis media found in 100% of heterozygotes mice are part of a more generalized respiratory tract inflammation

• no significant intralesional bacteria or viral inclusions

hematopoietic system

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

cellular

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

craniofacial

abnormal craniofacial morphology ( J:90559 )

• craniofacial defect

growth/size/body

decreased body weight ( J:90559 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:113445

Allelic Composition	Mecom^Jbo/Mecom⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecom^Jbo mutation (2 available); any Mecom mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:250208 )

N	• mice exhibit normal inner ear morphology

middle ear effusion ( J:250208 )

middle ear polyps ( J:250208 )

• edematous polyps projecting into the middle ear cavity

impaired hearing ( J:250208 )

• poor performance to the click-box

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

behavior/neurological

abnormal pinna reflex ( J:250208 )

• poor performance to the click-box

homeostasis/metabolism

middle ear effusion ( J:250208 )

immune system

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:250208

Allelic Composition	Mecom^Jbo/Mecom^tm1Mmor
Genetic Background	involves: 129S2/SvPas * BALB/c * C3H/HeN * CF-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecom^Jbo mutation (2 available); any Mecom mutation (81 available)
Mecom^tm1Mmor mutation (2 available); any Mecom mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:113445 )

• a complementation cross between Evi1^Jbo/ Evi1⁺ and Evi1^tm1Mmor/ Evi1⁺ produced no progeny among 81 live births which co-inherited the Evi1^Jbo and Evi1^tm1Mmor mutations, indicating perinatal lethality

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