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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l2tm1Sco
targeted mutation 1, Suzanne Cory
MGI:2158430
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l2tm1Sco/Bcl2l2tm1Sco involves: 129S1/Sv * C57BL/6 * FVB/N MGI:2176737


Genotype
MGI:2176737
hm1
Allelic
Composition		 Bcl2l2tm1Sco/Bcl2l2tm1Sco
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l2tm1Sco mutation (0 available); any Bcl2l2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:50338 )
• at 8 weeks of age the number of apoptotic male germ cells was 5 times the normal level, resulting in the testes losing 70% of their mass due to germ cell loss
azoospermia ( J:50338 )
• cauda epididymides of mutant mice are devoid of sperm
abnormal seminiferous tubule epithelium morphology ( J:50338 )
• numerous degenerating cells are present, some in the form of symplasts, giant cells containing multiple degenerating nuclei
decreased Sertoli cell number ( J:50338 )
• Sertoli cell numbers are reduced to 16% of their normal level at 6 weeks of age
small seminiferous tubules ( J:50338 )
• small in diameter and often lack a lumen

endocrine/exocrine glands
abnormal seminiferous tubule epithelium morphology ( J:50338 )
• numerous degenerating cells are present, some in the form of symplasts, giant cells containing multiple degenerating nuclei
decreased Sertoli cell number ( J:50338 )
• Sertoli cell numbers are reduced to 16% of their normal level at 6 weeks of age
small seminiferous tubules ( J:50338 )
• small in diameter and often lack a lumen

cellular
azoospermia ( J:50338 )
• cauda epididymides of mutant mice are devoid of sperm
increased male germ cell apoptosis ( J:50338 )
• at 8 weeks of age the number of apoptotic male germ cells was 5 times the normal level, resulting in the testes losing 70% of their mass due to germ cell loss




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory