Phenotypes associated with this allele

• Allele Symbol: Bcl6^tm1Rdf
• Allele Name: targeted mutation 1, Riccardo Dalla-Favera
• Allele ID: MGI:2158437
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl6^tm1Rdf/Bcl6^tm1Rdf	involves: 129S1/Sv	MGI:3582781

Genotype
MGI:3582781

hm1

• Allelic Composition: Bcl6^tm1Rdf/Bcl6^tm1Rdf
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:40769 )

• 51.7% the weight of wild-type at 6 months of age

spleen hyperplasia ( J:40769 )

• some mice exhibited hyperplasia due to infiltration by non-lymphoid cells and occasional hypoplasia in very young mice

immune system

abnormal immune system morphology ( J:40769 )

small thymus ( J:40769 )

• smaller in some mice, particularly in those with early infections

spleen hyperplasia ( J:40769 )

• some mice exhibited hyperplasia due to infiltration by non-lymphoid cells and occasional hypoplasia in very young mice

increased eosinophil cell number ( J:40769 )

• bone marrow showed a modest increase in eosinophilic precursors

absent spleen germinal center ( J:40769 )

• no germinal centers in the spleen of non-immunized mice or in mice immunized with T-dependent antigen

abnormal Peyer's patch germinal center morphology ( J:40769 )

• failed to form a germinal center upon immunization with the T-dependent antigen

absent lymph node germinal center ( J:40769 )

• failed to form a germinal center in the lymph nodes upon immunization with the T-dependent antigen

abnormal immune system physiology ( J:40769 )

abnormal B cell physiology ( J:40769 )

• increase in IgG- and IgE-bearing B cells

decreased IgG level ( J:40769 )

• 4-20-fold reduction for all IgG subtypes compared to wild-type when immunized with the T-cell dependent antigen

decreased IgM level ( J:40769 )

• 2-fold reduction compared to wild-type when immunized with the T-cell dependent antigen

abnormal T-helper 2 physiology ( J:40769 )

• defect in T-cell-dependent antibody responses resulting in the development of a Th2-type inflammatory disease

abnormal humoral immune response ( J:40769 )

• reduced T-cell-dependent antibody response of most Ig isotypes

• complete lack of affinity maturation

increased inflammatory response ( J:40769 )

• develop a Th2-type inflammatory disease involving multiple organs including the myocardium, spleen, gut, liver, lacrimal gland and skin, characterized by infiltrations of eosinophils and IgE-bearing B lymphocytes

heart inflammation ( J:40769 )

• presence of eosinophilic infiltrates in the heart

liver inflammation ( J:40769 )

lung inflammation ( J:40769 )

• presence of eosinophilic infiltrates in lung, heart and mediastinal lymph nodes that was associated with acidophilic macrophage pneumonia (characterized by the infiltration of macrophages filled by degradation products of eosinophils)

increased susceptibility to bacterial infection ( J:40769 )

• about half displayed infections within the first 3 months of life, most frequently involving the oesophagus as well as other mucosal sites in the upper respiratory and digestive tracts and the lung

hematopoietic system

small thymus ( J:40769 )

• smaller in some mice, particularly in those with early infections

spleen hyperplasia ( J:40769 )

• some mice exhibited hyperplasia due to infiltration by non-lymphoid cells and occasional hypoplasia in very young mice

increased eosinophil cell number ( J:40769 )

• bone marrow showed a modest increase in eosinophilic precursors

absent spleen germinal center ( J:40769 )

• no germinal centers in the spleen of non-immunized mice or in mice immunized with T-dependent antigen

abnormal B cell physiology ( J:40769 )

• increase in IgG- and IgE-bearing B cells

decreased IgG level ( J:40769 )

• 4-20-fold reduction for all IgG subtypes compared to wild-type when immunized with the T-cell dependent antigen

decreased IgM level ( J:40769 )

• 2-fold reduction compared to wild-type when immunized with the T-cell dependent antigen

abnormal T-helper 2 physiology ( J:40769 )

• defect in T-cell-dependent antibody responses resulting in the development of a Th2-type inflammatory disease

respiratory system

lung inflammation ( J:40769 )

• presence of eosinophilic infiltrates in lung, heart and mediastinal lymph nodes that was associated with acidophilic macrophage pneumonia (characterized by the infiltration of macrophages filled by degradation products of eosinophils)

cardiovascular system

heart inflammation ( J:40769 )

• presence of eosinophilic infiltrates in the heart

liver/biliary system

liver inflammation ( J:40769 )

endocrine/exocrine glands

small thymus ( J:40769 )

• smaller in some mice, particularly in those with early infections