Analysis Tools
mortality/aging
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• runted, sickly mice are born in less than the expected Mendelian ratios
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growth/size/body
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• runted, sickly mice
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• 42.8% the weight of wild-type at 6 months of age
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• some mice exhibited hyperplasia due to infiltration by non-lymphoid cells and occasional hypoplasia in very young mice
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immune system
small thymus
(
J:40769
)
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• smaller in some mice, particularly in those with early infections
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• some mice exhibited hyperplasia due to infiltration by non-lymphoid cells and occasional hypoplasia in very young mice
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• bone marrow showed a modest increase in eosinophilic precursors
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• no germinal centers in the spleen of non-immunized mice or in mice immunized with T-dependent antigen
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• failed to form a germinal center upon immunization with the T-dependent antigen
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• failed to form a germinal center in the lymph nodes upon immunization with the T-dependent antigen
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• increase in IgG- and IgE-bearing B cells
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• follicular B cells did not proliferate
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• 4-20-fold reduction for all IgG subtypes compared to wild-type when immunized with the T-cell dependent antigen
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• 2-fold reduction compared to wild-type when immunized with the T-cell dependent antigen
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• defect in T-cell-dependent antibody responses resulting in the development of a Th2-type inflammatory disease
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• reduced T-cell-dependent antibody response of most Ig isotypes
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• develop a Th2-type inflammatory disease involving multiple organs including the myocardium, spleen, gut, liver, lacrimal gland and skin, characterized by infiltrations of eosinophils and IgE-bearing B lymphocytes
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• presence of eosinophilic infiltrates in the heart
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• presence of eosinophilic infiltrates in lung, heart and mediastinal lymph nodes that was associated with acidophilic macrophage pneumonia (characterized by the infiltration of macrophages filled by degradation products of eosinophils)
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• about half displayed infections within the first 3 months of life, most frequently involving the oesophagus as well as other mucosal sites in the upper respiratory and digestive tracts and the lung
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hematopoietic system
small thymus
(
J:40769
)
|
• smaller in some mice, particularly in those with early infections
|
|
• some mice exhibited hyperplasia due to infiltration by non-lymphoid cells and occasional hypoplasia in very young mice
|
|
• bone marrow showed a modest increase in eosinophilic precursors
|
|
• no germinal centers in the spleen of non-immunized mice or in mice immunized with T-dependent antigen
|
|
• increase in IgG- and IgE-bearing B cells
|
|
• follicular B cells did not proliferate
|
|
• 4-20-fold reduction for all IgG subtypes compared to wild-type when immunized with the T-cell dependent antigen
|
|
• 2-fold reduction compared to wild-type when immunized with the T-cell dependent antigen
|
|
• defect in T-cell-dependent antibody responses resulting in the development of a Th2-type inflammatory disease
|
respiratory system
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• presence of eosinophilic infiltrates in lung, heart and mediastinal lymph nodes that was associated with acidophilic macrophage pneumonia (characterized by the infiltration of macrophages filled by degradation products of eosinophils)
|
cardiovascular system
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• presence of eosinophilic infiltrates in the heart
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liver/biliary system
endocrine/exocrine glands
small thymus
(
J:40769
)
|
• smaller in some mice, particularly in those with early infections
|
cellular
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• follicular B cells did not proliferate
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