About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6tm1Sdt
targeted mutation 1, Louis M Staudt
MGI:2158439
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl6tm1Sdt/Bcl6tm1Sdt involves: 129/Sv * C57BL/6 MGI:3719163
cx2
 		Bcl6tm1Sdt/Bcl6tm1Sdt
Bcl6btm2Dent/Bcl6btm2Dent 		involves: 129/Sv * C57BL/6 MGI:3719166


Genotype
MGI:3719163
hm1
Allelic
Composition		 Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1Sdt mutation (1 available); any Bcl6 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:123621 )
• mice frequently die before reaching maturation

growth/size/body
postnatal growth retardation ( J:123621 )
• severe

hematopoietic system
abnormal blood cell morphology/development ( J:123621 )
• fewer hematopoeitic progenitor cells (HPCs) are detected and the proportion of proliferating cells is decreased
• the number of HPCs in the spleen is increased, with the number of myeloid and multipotential progenitors most significantly increased, and more cells are in a proliferative state compared to in wild-type mice
• following stimulation with growth factors and chemokine treatment in vivo, HPCs are unresponsive to chemokine-induced myelosuppression
• however, HPCs are sensitive to inhibition by TNF-alpha however, HPCs are sensitive to inhibition by TNF-alpha
decreased bone marrow cell number ( J:123621 )
• nucleated-cellularity is decreased by 45% compared to wild-type mice
• however, hypocellularity is consistent with the overall small size of mice
spleen hypoplasia ( J:123621 )
• nucleated-cellularity is decreased by 26% compared to wild-type mice
• however, hypocellularity is consistent with the overall small size of mice

immune system
spleen hypoplasia ( J:123621 )
• nucleated-cellularity is decreased by 26% compared to wild-type mice
• however, hypocellularity is consistent with the overall small size of mice
abnormal immune system physiology ( J:123621 )
• Th2-type inflammation develops spontaneously in the heart and lung
abnormal chemokine level ( J:123621 )
• chemokine levels are greatly increased compared to those in wild-type mice

homeostasis/metabolism
abnormal chemokine level ( J:123621 )
• chemokine levels are greatly increased compared to those in wild-type mice




Genotype
MGI:3719166
cx2
Allelic
Composition		 Bcl6tm1Sdt/Bcl6tm1Sdt
Bcl6btm2Dent/Bcl6btm2Dent
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6btm2Dent mutation (0 available); any Bcl6b mutation (14 available)
Bcl6tm1Sdt mutation (1 available); any Bcl6 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:123621 )
• growth retardation is similar to that seem in Bcl6tm1Sdt homozygotes

immune system
abnormal immune system physiology ( J:123621 )
• Th2-type inflammation develops spontaneously in the heart and lung




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory