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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6tm1Sdt
targeted mutation 1, Louis M Staudt
MGI:2158439
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl6tm1Sdt/Bcl6tm1Sdt involves: 129/Sv * C57BL/6 MGI:3719163
cx2
 		Bcl6tm1Sdt/Bcl6tm1Sdt
Bcl6btm2Dent/Bcl6btm2Dent 		involves: 129/Sv * C57BL/6 MGI:3719166


Genotype
MGI:3719163
hm1
Allelic
Composition		 Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1Sdt mutation (1 available); any Bcl6 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:123621 )
• mice frequently die before reaching maturation

growth/size/body
postnatal growth retardation ( J:123621 )
• severe

hematopoietic system
abnormal blood cell morphology/development ( J:123621 )
• fewer hematopoeitic progenitor cells (HPCs) are detected and the proportion of proliferating cells is decreased
• the number of HPCs in the spleen is increased, with the number of myeloid and multipotential progenitors most significantly increased, and more cells are in a proliferative state compared to in wild-type mice
• following stimulation with growth factors and chemokine treatment in vivo, HPCs are unresponsive to chemokine-induced myelosuppression
• however, HPCs are sensitive to inhibition by TNF-alpha however, HPCs are sensitive to inhibition by TNF-alpha
decreased bone marrow cell number ( J:123621 )
• nucleated-cellularity is decreased by 45% compared to wild-type mice
• however, hypocellularity is consistent with the overall small size of mice
spleen hypoplasia ( J:123621 )
• nucleated-cellularity is decreased by 26% compared to wild-type mice
• however, hypocellularity is consistent with the overall small size of mice

immune system
spleen hypoplasia ( J:123621 )
• nucleated-cellularity is decreased by 26% compared to wild-type mice
• however, hypocellularity is consistent with the overall small size of mice
abnormal immune system physiology ( J:123621 )
• Th2-type inflammation develops spontaneously in the heart and lung
abnormal chemokine level ( J:123621 )
• chemokine levels are greatly increased compared to those in wild-type mice

homeostasis/metabolism
abnormal chemokine level ( J:123621 )
• chemokine levels are greatly increased compared to those in wild-type mice




Genotype
MGI:3719166
cx2
Allelic
Composition		 Bcl6tm1Sdt/Bcl6tm1Sdt
Bcl6btm2Dent/Bcl6btm2Dent
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6btm2Dent mutation (0 available); any Bcl6b mutation (16 available)
Bcl6tm1Sdt mutation (1 available); any Bcl6 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:123621 )
• growth retardation is similar to that seem in Bcl6tm1Sdt homozygotes

immune system
abnormal immune system physiology ( J:123621 )
• Th2-type inflammation develops spontaneously in the heart and lung




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory