All Phenotypes Gli2<tm2.1Alj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli2^tm2.1Alj
targeted mutation 2.1, Alexandra L Joyner
MGI:2158472

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli2^tm2.1Alj/Gli2^tm2.1Alj	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:2173467
hm2	Gli2^tm2.1Alj/Gli2^tm2.1Alj	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster	MGI:3795685
hm3	Gli2^tm2.1Alj/Gli2^tm2.1Alj	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster	MGI:4941343
ht4	Gli2^tm1Alj/Gli2^tm2.1Alj	either: (involves: 129) or (involves: 129 * Black Swiss)	MGI:2173471
ht5	Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj}	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3846347
ht6	Gli2^tm2.1Alj/Gli2^tm3(Gli1)Alj	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3846348
cx7	Gli2^tm2.1Alj/Gli2^tm2.1Alj Shh^tm1Chg/Shh^tm1Chg	either: (involves: 129) or (involves: 129 * Black Swiss)	MGI:2173463
cx8	Gli2^tm2.1Alj/Gli2⁺ Shh^tm1Chg/Shh^tm1Chg	either: (involves: 129) or (involves: 129 * Black Swiss)	MGI:3846351
cx9	Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj} Shh^tm1Chg/Shh^tm1Chg	either: (involves: 129) or (involves: 129 * Black Swiss)	MGI:3846352
cx10	Gli2^tm2.1Alj/Gli2^tm2.1Alj Gli3^Xt-J/Gli3⁺	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	MGI:3795688
cx11	Gli2^tm2.1Alj/Gli2^tm2.1Alj Gli3^Xt-J/Gli3^Xt-J	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	MGI:3795689
cx12	Gli2^tm2.1Alj/Gli2⁺ Gli3^Xt-J/Gli3^Xt-J	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	MGI:3795690
cx13	Gli2^tm2.1Alj/Gli2^tm2.1Alj Tmem107^schlei/Tmem107^schlei	involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6J	MGI:5433095

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent floor plate ( J:73074 )

• at E10.5 cells that express Shh and Foxa2 are absent

abnormal spinal cord morphology ( J:73074 )

• at E10.5 motor neurons occupy the ventral midline of the spinal cord

• the notochord is situated closer to the spinal cord

abnormal ventral interneuron 3 morphology ( J:73074 )

• decrease in the number of spinal cord V3 interneurons that are normally adjacent to the floor plate at E10.5

embryo

absent floor plate ( J:73074 )

• at E10.5 cells that express Shh and Foxa2 are absent

abnormal notochord morphology ( J:73074 )

• at E10.5 cells that express Shh and Foxa2 are absent

• the notochord is situated closer to the spinal cord

persistence of notochord tissue ( J:73074 )

• the notochord fails to regress

respiratory system

absent right lung accessory lobe ( J:73074 )

• the accessory lobe is absent

small lung ( J:73074 )

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:112460 )

reproductive system

reproductive system phenotype ( J:112460 )

N	• embryos show normal mammary gland development at E13

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal floor plate morphology ( J:169530 )

• the Nkx2-2 expressing domains are absent and the motor neurons appear fused together

nervous system

abnormal floor plate morphology ( J:169530 )

• the Nkx2-2 expressing domains are absent and the motor neurons appear fused together

abnormal motor neuron morphology ( J:169530 )

• in the floor plate the motor neurons appear fused together

Allelic Composition	Gli2^tm1Alj/Gli2^tm2.1Alj
Genetic Background	either: (involves: 129) or (involves: 129 * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent floor plate ( J:73074 )

• at E10.5 cells that express Shh and Foxa2 are absent

abnormal spinal cord morphology ( J:73074 )

• at E10.5 motor neurons occupy the ventral midline of the spinal cord

• the notochord is situated closer to the spinal cord

abnormal ventral interneuron 3 morphology ( J:73074 )

• decrease in the number of spinal cord V3 interneurons that are normally adjacent to the floor plate at E10.5

embryo

absent floor plate ( J:73074 )

• at E10.5 cells that express Shh and Foxa2 are absent

abnormal notochord morphology ( J:73074 )

• at E10.5 cells that express Shh and Foxa2 are absent

• the notochord is situated closer to the spinal cord

persistence of notochord tissue ( J:73074 )

• the notochord fails to regress

respiratory system

absent right lung accessory lobe ( J:73074 )

• the accessory lobe is absent

small lung ( J:73074 )

Allelic Composition	Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj}
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:73074 )

N	• unlike in homozygous null mice, at E10.5 the floor plate is present, interneurons are found in the appropriate location, and notochord regression is normal

respiratory system

respiratory system phenotype ( J:73074 )

N	• unlike in homozygous null mice, at E12.5 lung size is normal and the accessory lobe is present

integument

progressive hair loss ( J:73074 )

• gradual loss of hair beginning on the dorsal neck and preceding caudally down the back in mice over 3 weeks of age

• around 5 months of age mice lack hair around the neck

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm3(Gli1)Alj
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Gli2^tm3(Gli1)Alj mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:73074 )

• viable with no gross abnormalities

• unlike in homozygous null mice, at E10.5 the floor plate is present, interneurons are found in the appropriate location, and notochord regression is normal

• unlike in homozygous null mice, at E12.5 lung size is normal and the accessory lobe is present

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj Shh^tm1Chg/Shh^tm1Chg
Genetic Background	either: (involves: 129) or (involves: 129 * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent floor plate ( J:73074 )

• at E10.5

decreased motor neuron number ( J:73074 )

• absent from the spinal cord at E10.5

abnormal spinal cord interneuron morphology ( J:73074 )

• absent at E10.5

vision/eye

cyclopia ( J:73074 )

• at E10.5

embryo

absent floor plate ( J:73074 )

• at E10.5

Allelic Composition	Gli2^tm2.1Alj/Gli2⁺ Shh^tm1Chg/Shh^tm1Chg
Genetic Background	either: (involves: 129) or (involves: 129 * Black Swiss)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:73074 )

• at E10.5

nervous system

abnormal telencephalon development ( J:73074 )

• fused telencephalic vesicles are seen at E10.5

abnormal spinal cord morphology ( J:73074 )

• loss of many ventral tissues is seen at E10.5

growth/size/body

decreased embryo size ( J:73074 )

• at E10.5

Allelic Composition	Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj} Shh^tm1Chg/Shh^tm1Chg
Genetic Background	either: (involves: 129) or (involves: 129 * Black Swiss)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent floor plate ( J:73074 )

• at E10.5

abnormal diencephalon morphology ( J:73074 )

• in about half of mice development of the diencephalic vesicles is partially rescued with partial separation into 2 vesicles seen at E10.5 or E11.5

decreased motor neuron number ( J:73074 )

• absent from the spinal cord at E10.5

abnormal ventral interneuron 3 morphology ( J:73074 )

• absence of V3 interneurons at E10.5

embryo

absent floor plate ( J:73074 )

• at E10.5

growth/size/body

megacephaly ( J:73074 )

• head size is increased compared to mice homozygous null for Shh alone

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:112460 )

N	• embryos show normal mammary gland development

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:112460 )

• embryos die around E10.5

Allelic Composition	Gli2^tm2.1Alj/Gli2⁺ Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland bud morphology ( J:112460 )

• some embryos lack mammary bud pair number 3 and number 5

integument

abnormal mammary gland bud morphology ( J:112460 )

• some embryos lack mammary bud pair number 3 and number 5

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj Tmem107^schlei/Tmem107^schlei
Genetic Background	involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Tmem107^schlei mutation (0 available); any Tmem107 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal floor plate morphology ( J:186552 )

• mice exhibit loss of floor plate cells and V3 interneurons

• however, dorsal expansion of V2 interneuron progenitors observed in Tmem107^schlei homozygotes is blocked

nervous system

abnormal floor plate morphology ( J:186552 )

• mice exhibit loss of floor plate cells and V3 interneurons

• however, dorsal expansion of V2 interneuron progenitors observed in Tmem107^schlei homozygotes is blocked

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