All Phenotypes Igh-8<tm1Schr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh-8^tm1Schr
targeted mutation 1, John R Schreiber
MGI:2158494

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-8^tm1Schr/Igh-8^tm1Schr	C.129P2(BKSW)-Igh-8^tm1Schr	MGI:3603534
hm2	Igh-8^tm1Schr/Igh-8^tm1Schr	involves: 129P2/OlaHsd * Black Swiss	MGI:3603533

Allelic Composition	Igh-8^tm1Schr/Igh-8^tm1Schr
Genetic Background	C.129P2(BKSW)-Igh-8^tm1Schr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-8^tm1Schr mutation (2 available); any Igh-8 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased IgG level ( J:75577 )

• high titers of IgG1 and lower titers of IgG2 after immunization with pneumococcal capsular polysaccharide

increased IgM level ( J:75577 )

• high titers of IgM after immunization with pneumococcal capsular polysaccharide

• in spite of high titers of T-independent antibodies, mortality to Pneumococcus challenge remained high

• when T-dependent antibodies were produced instead, response to bacterial challenge was better

hematopoietic system