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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Blmtm3Brd
targeted mutation 3, Allan Bradley
MGI:2158670
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Blmtm3Brd/Blmtm3Brd involves: 129S7/SvEvBrd * C57BL/6 MGI:2683906
ht2
 		Blmtm1Ches/Blmtm3Brd involves: 129S/SvEv * C57BL/6 * NIH Black Swiss MGI:2683845
ht3
 		Blmtm2Brd/Blmtm3Brd involves: 129S7/SvEvBrd * C57BL/6 MGI:2683903
cx4
 		Aicdatm1Hon/Aicdatm1Hon
Blmtm3Brd/Blmtm3Brd
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5484527


Genotype
MGI:2683906
hm1
Allelic
Composition		 Blmtm3Brd/Blmtm3Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blmtm3Brd mutation (1 available); any Blm mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:66261 )
• tumor development after 1 year of age
• 29% of mice with tumors by 20 months
increased lymphoma incidence ( J:66261 )
• about 60% of spontaneous tumors are lymphomas

immune system
decreased IgM level ( J:66261 )
• concentration reduced by 10%

hematopoietic system
decreased IgM level ( J:66261 )
• concentration reduced by 10%

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Bloom syndrome DOID:2717 OMIM:210900
 J:66261




Genotype
MGI:2683845
ht2
Allelic
Composition		 Blmtm1Ches/Blmtm3Brd
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blmtm1Ches mutation (0 available); any Blm mutation (88 available)
Blmtm3Brd mutation (1 available); any Blm mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:86827 )
• considerable increase in tumor incidence
increased lymphoma incidence ( J:86827 )
• about half of spontaneous tumors are lymphomas

growth/size/body
postnatal growth retardation ( J:86827 )
• normal size at birth
• slight growth deficit by 16 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Bloom syndrome DOID:2717 OMIM:210900
 J:86827




Genotype
MGI:2683903
ht3
Allelic
Composition		 Blmtm2Brd/Blmtm3Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blmtm2Brd mutation (0 available); any Blm mutation (88 available)
Blmtm3Brd mutation (1 available); any Blm mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5484527
cx4
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Blmtm3Brd/Blmtm3Brd
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Blmtm3Brd mutation (1 available); any Blm mutation (88 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194603 )
N
• B cells exhibit normal resection and junctional microhomology




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory