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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		C3ar1tm1Cge
targeted mutation 1, Craig Gerard
MGI:2158678
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		C3ar1tm1Cge/C3ar1tm1Cge B6.129S4(C)-C3ar1tm1Cge MGI:6382538
hm2
 		C3ar1tm1Cge/C3ar1tm1Cge involves: 129S4/SvJae * BALB/c MGI:2449064
hm3
 		C3ar1tm1Cge/C3ar1tm1Cge involves: 129S4/SvJae * C57BL/6 MGI:5295997
cx4
 		C3ar1tm1Cge/C3ar1tm1Cge
C5ar1tm1Cge/C5ar1tm1Cge 		B6.Cg-C3ar1tm1Cge C5ar1tm1Cge MGI:6382540


Genotype
MGI:6382538
hm1
Allelic
Composition		 C3ar1tm1Cge/C3ar1tm1Cge
Genetic
Background		 B6.129S4(C)-C3ar1tm1Cge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3ar1tm1Cge mutation (2 available); any C3ar1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
increased retina apoptosis ( J:214214 )
• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months
abnormal retina rod bipolar cell morphology ( J:214214 )
• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age
abnormal retina horizontal cell morphology ( J:214214 )
• density of horizontal cells is decreased
thin retina inner nuclear layer ( J:214214 )
• the inner nuclear layer is thinner at 3 and 14 months of age
thin retina outer nuclear layer ( J:214214 )
• outer nuclear layer thinning is seen at older ages
disorganized retina outer nuclear layer ( J:214214 )
• the outer nuclear layer is disorganized at 3 months of age
increased susceptibility to age-related retinal degeneration ( J:214214 )
• mice show progressive retinal cell loss
decreased a-wave amplitude ( J:214214 )
• by 14 weeks of age, but not at 6 weeks, ERG a-waves are reduced and the reduction progresses with increasing age
• after an 8-hour light exposure, mice show a greater loss of retinal function than wild-type mice, showing decreased a-wave amplitude
decreased b-wave amplitude ( J:214214 )
• by 14 weeks of age, but not at 6 weeks, ERG b-waves are reduced and the reduction progresses with increasing age
• after an 8-hour light exposure, mice show a greater loss of retinal function than wild-type mice, showing decreased b-wave amplitude
abnormal c-wave shape ( J:214214 )
• the amplitude of the c-wave is reduced at 12 months of age, but not at 8 weeks of age
• however, no other component of the dc-ERG is different

nervous system
abnormal retina rod bipolar cell morphology ( J:214214 )
• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age
abnormal retina horizontal cell morphology ( J:214214 )
• density of horizontal cells is decreased

homeostasis/metabolism
decreased circulating free fatty acids level ( J:214214 )
• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age
decreased circulating phospholipid level ( J:214214 )
• plasma lysophosphatidylcholine levels are decreased at 3 and 14 months of age

cellular
increased retina apoptosis ( J:214214 )
• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months




Genotype
MGI:2449064
hm2
Allelic
Composition		 C3ar1tm1Cge/C3ar1tm1Cge
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3ar1tm1Cge mutation (2 available); any C3ar1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:64378 )
N
• homozygotes are obtained at the expected Mendelian ratios, are fertile and display no gross developmental or morphological defects when raised under SPF conditions

respiratory system
decreased airway responsiveness ( J:64378 )
• in an ovalbumin-induced model of allergic asthma, unrestrained conscious homozygotes fail to exhibit increased airway hyper-responsiveness (AHR) in response to inhaled methacholine
• similar results are obtained using the same protocol with anesthetized, mechanically ventilated homozygotes and measuring AHR in response to intravenous methacholine
• at 6 or 24 hrs after last allergen challenge, homozygotes show no significant differences in eosinophil numbers (in either BAL or lung tissue), IgE levels or BAL fluid levels of interleukin IL-4, IL-5 and IL-13 relative to wild-type mice




Genotype
MGI:5295997
hm3
Allelic
Composition		 C3ar1tm1Cge/C3ar1tm1Cge
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3ar1tm1Cge mutation (2 available); any C3ar1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased osteoclast cell number ( J:166640 )
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

immune system
decreased osteoclast cell number ( J:166640 )
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls
decreased circulating interleukin-6 level ( J:166640 )
• Il-6 production after vitamin D3 stimulation is significantly reduced

hematopoietic system
decreased osteoclast cell number ( J:166640 )
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:166640 )
• Il-6 production after vitamin D3 stimulation is significantly reduced




Genotype
MGI:6382540
cx4
Allelic
Composition		 C3ar1tm1Cge/C3ar1tm1Cge
C5ar1tm1Cge/C5ar1tm1Cge
Genetic
Background		 B6.Cg-C3ar1tm1Cge C5ar1tm1Cge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3ar1tm1Cge mutation (2 available); any C3ar1 mutation (36 available)
C5ar1tm1Cge mutation (3 available); any C5ar1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
increased retina apoptosis ( J:214214 )
• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice
abnormal retina rod bipolar cell morphology ( J:214214 )
• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age
abnormal retina horizontal cell morphology ( J:214214 )
• density of horizontal cells is decreased
abnormal photoreceptor outer segment disc membrane morphology ( J:214214 )
• the normal structure of the outer segment discs is lost at 6 months of age
abnormal retina pigment epithelium morphology ( J:214214 )
• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months
thin retina inner nuclear layer ( J:214214 )
• the inner nuclear layer is thinner at 3 and 14 months of age
thin retina outer nuclear layer ( J:214214 )
• outer nuclear layer thinning is seen at older ages
disorganized retina outer nuclear layer ( J:214214 )
• the outer nuclear layer is disorganized at 3 months of age
increased susceptibility to age-related retinal degeneration ( J:214214 )
• mice show progressive retinal cell loss
abnormal electroretinogram waveform feature ( J:214214 )
• the fast oscillation is reduced at 6 months of age
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show a more severe reduction in ERG amplitude, however this phenotype is not related to immune responses as IL17-producting cells are diminished
decreased a-wave amplitude ( J:214214 )
• by 14 weeks of age, but not at 6 weeks, ERG a-waves are reduced and the reduction progresses with increasing age
decreased b-wave amplitude ( J:214214 )
• by 14 weeks of age, but not at 6 weeks, ERG b-waves are reduced and the reduction progresses with increasing age
abnormal c-wave shape ( J:214214 )
• the amplitude of the c-wave is reduced at 6 months of age

homeostasis/metabolism
decreased circulating free fatty acids level ( J:214214 )
• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age
decreased circulating phospholipid level ( J:214214 )
• plasma lysophosphatidylcholine levels are decreased at 3 and 14 months of age

cellular
increased retina apoptosis ( J:214214 )
• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice

nervous system
abnormal retina rod bipolar cell morphology ( J:214214 )
• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age
abnormal retina horizontal cell morphology ( J:214214 )
• density of horizontal cells is decreased
abnormal photoreceptor outer segment disc membrane morphology ( J:214214 )
• the normal structure of the outer segment discs is lost at 6 months of age

pigmentation
abnormal retina pigment epithelium morphology ( J:214214 )
• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory