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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cr1ltm1Hmo
targeted mutation 1, Hector Molina
MGI:2158683
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cr1ltm1Hmo/Cr1ltm1Hmo involves: 129X1/SvJ MGI:3697585
ht2
 		Cr1ltm1Hmo/Cr1l+ involves: 129X1/SvJ MGI:3697586
cx3
 		Cfptm1Song/Cfptm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo 		involves: 129 * 129X1/SvJ * C57BL/6 MGI:4838308
cx4
 		C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo 		involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:3806100
cx5
 		C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo
Vsig4tm1Gne/Vsig4tm1Gne 		involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N MGI:3806101
cx6
 		C3tm1Hrc/C3tm1Hrc
Cr1ltm1Hmo/Cr1ltm1Hmo 		involves: 129/Sv * 129X1/SvJ * C57BL/6 MGI:3505876


Genotype
MGI:3697585
hm1
Allelic
Composition		 Cr1ltm1Hmo/Cr1ltm1Hmo
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:197576 )
N
• homozygotes from mothers that are treated with a blocking anti-C5 antibody throughout pregnancy survive to adulthood
lethality throughout fetal growth and development, complete penetrance ( J:59432 )
• normal frequency of homozygotes until around E9.5
• all are dead by E16.5

embryo
abnormal trophectoderm morphology ( J:59432 )
• C3 (complement) deposited on the surface
abnormal ectoplacental cone morphology ( J:59432 )
• C3 (complement) deposited on the surface
abnormal maternal decidual layer morphology ( J:59432 )
• reduced deciduas at E9.5

immune system
increased inflammatory response ( J:59432 )
• extensive invasion of polymorphonuclear inflammatory granulocytes around the ectoplacental cone and the trophoectoderm

reproductive system
abnormal maternal decidual layer morphology ( J:59432 )
• reduced deciduas at E9.5

nervous system
abnormal hippocampus morphology ( J:197576 )
• 20 week-old mutants (from mothers treated with an anti-C5 antibody throughout pregnancy) show a reduction in complement factor H and a decrease in tau phosphorylation in the hippocampus, both markers of Alzheimer's disease




Genotype
MGI:3697586
ht2
Allelic
Composition		 Cr1ltm1Hmo/Cr1l+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased blood urea nitrogen level ( J:105466 )
• significantly elevated serum urea nitrogen following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion
increased susceptibility to kidney reperfusion injury ( J:105466 )
• significantly greater injury following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion particularly in the proximal tubules

renal/urinary system
increased susceptibility to kidney reperfusion injury ( J:105466 )
• significantly greater injury following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion particularly in the proximal tubules
abnormal proximal convoluted tubule morphology ( J:105466 )
• significantly greater injury following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion particularly in the proximal tubules




Genotype
MGI:4838308
cx3
Allelic
Composition		 Cfptm1Song/Cfptm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo
Genetic
Background		 involves: 129 * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfptm1Song mutation (0 available); any Cfp mutation (5 available)
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:165497 )
N
• mice are produced in Mendelian ratios unlike Cr1ltm1Hmo homozygotes that exhibit embryonic lethality




Genotype
MGI:3806100
cx4
Allelic
Composition		 C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Hrc mutation (2 available); any C3 mutation (103 available)
Cd55tm1Song mutation (2 available); any Cd55 mutation (39 available)
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet physiology ( J:138410 )
• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation

homeostasis/metabolism
abnormal platelet physiology ( J:138410 )
• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation




Genotype
MGI:3806101
cx5
Allelic
Composition		 C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo
Vsig4tm1Gne/Vsig4tm1Gne
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Hrc mutation (2 available); any C3 mutation (103 available)
Cd55tm1Song mutation (2 available); any Cd55 mutation (39 available)
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (30 available)
Vsig4tm1Gne mutation (0 available); any Vsig4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet physiology ( J:138410 )
• unlike in C3tm1Hrc Cd55tm1Song Cr1ltm1Hmo homozygotes, platelet half-life is normal

homeostasis/metabolism
abnormal platelet physiology ( J:138410 )
• unlike in C3tm1Hrc Cd55tm1Song Cr1ltm1Hmo homozygotes, platelet half-life is normal




Genotype
MGI:3505876
cx6
Allelic
Composition		 C3tm1Hrc/C3tm1Hrc
Cr1ltm1Hmo/Cr1ltm1Hmo
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Hrc mutation (2 available); any C3 mutation (103 available)
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:59432 )
N
• survival of double homozygotes is normal

immune system
abnormal complement pathway ( J:76578 )
• erythrocytes show slightly increased susceptibility to antibody-induced lysis by human, but not by rat, complement compared to wild-type
• antibody-sensitized erythrocytes exhibit increased C3 deposition compared to wild-type cells
• mutant erythrocytes transfused into wild-type mice are more rapidly eliminated than controls indicating increased susceptibility to spontaneous complement attack in vivo, however cells are protected from removal when transfused to C3 deficient mice

reproductive system
reproductive system phenotype ( J:86999 )
N
• when mating double homozygous females to Crrytm1Hmo heterozygous males the expected number of pups of both possible genotypes are seen unlike in the reverse situation when fewer than expected Crrytm1Hmo homozygous pups are found




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory